Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland
Haplotypes including HLA, Bf and C4 loci were analyzed in a material comprising 55 families with diabetic children. One hundred and ten haplotypes found in IDDM patients were compared with 101 haplotypes present only in healthy family members. Two complotypes, BfSC4A3B3 and SC4A0B1 . were significan...
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crwiley:10.1111/j.1399-0039.1988.tb01649.x 2024-06-02T08:12:00+00:00 Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland Ilonen, J. Surcel, H.‐M. Partanen, J. Koskimies, S. Knip, M. Käär, M.‐L. 1988 http://dx.doi.org/10.1111/j.1399-0039.1988.tb01649.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1988.tb01649.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1988.tb01649.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Tissue Antigens volume 32, issue 3, page 139-144 ISSN 0001-2815 1399-0039 journal-article 1988 crwiley https://doi.org/10.1111/j.1399-0039.1988.tb01649.x 2024-05-03T10:38:43Z Haplotypes including HLA, Bf and C4 loci were analyzed in a material comprising 55 families with diabetic children. One hundred and ten haplotypes found in IDDM patients were compared with 101 haplotypes present only in healthy family members. Two complotypes, BfSC4A3B3 and SC4A0B1 . were significantly more common (P <0.05) in the diabetic haplotypes, and these were in most cases found in haplotypic combinations with HLA‐B15,Dw4,DR4 and HLA‐B8.Dw3,DR3 genes, respectively. The B8/DR3 haplotype was better conserved, as 72% included the BfSC4A0B1 complotype as compared with only 35% of the B15/DR4 haplotypes with “high risk” C4A3B3 complement alleles (p <0.05). DR3 was found in 26% of the diabetic haplotypes and DR4 in 43%. DR4 associated with the Dw4 in 69% of cases and with D w14 in 26% of the diabetic haplotypes. Our results confirm that the two phenotypes found earlier to be associated with IDDM in Northern Finland, e.g. “B15, BfS, C4A3B3, Dw4, DR4” and “B8, BfS, C4A0B1, Dw3, DR3” are inherited as haplotypes. Article in Journal/Newspaper Northern Finland Wiley Online Library Tissue Antigens 32 3 139 144 |
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Wiley Online Library |
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English |
description |
Haplotypes including HLA, Bf and C4 loci were analyzed in a material comprising 55 families with diabetic children. One hundred and ten haplotypes found in IDDM patients were compared with 101 haplotypes present only in healthy family members. Two complotypes, BfSC4A3B3 and SC4A0B1 . were significantly more common (P <0.05) in the diabetic haplotypes, and these were in most cases found in haplotypic combinations with HLA‐B15,Dw4,DR4 and HLA‐B8.Dw3,DR3 genes, respectively. The B8/DR3 haplotype was better conserved, as 72% included the BfSC4A0B1 complotype as compared with only 35% of the B15/DR4 haplotypes with “high risk” C4A3B3 complement alleles (p <0.05). DR3 was found in 26% of the diabetic haplotypes and DR4 in 43%. DR4 associated with the Dw4 in 69% of cases and with D w14 in 26% of the diabetic haplotypes. Our results confirm that the two phenotypes found earlier to be associated with IDDM in Northern Finland, e.g. “B15, BfS, C4A3B3, Dw4, DR4” and “B8, BfS, C4A0B1, Dw3, DR3” are inherited as haplotypes. |
format |
Article in Journal/Newspaper |
author |
Ilonen, J. Surcel, H.‐M. Partanen, J. Koskimies, S. Knip, M. Käär, M.‐L. |
spellingShingle |
Ilonen, J. Surcel, H.‐M. Partanen, J. Koskimies, S. Knip, M. Käär, M.‐L. Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland |
author_facet |
Ilonen, J. Surcel, H.‐M. Partanen, J. Koskimies, S. Knip, M. Käär, M.‐L. |
author_sort |
Ilonen, J. |
title |
Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland |
title_short |
Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland |
title_full |
Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland |
title_fullStr |
Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland |
title_full_unstemmed |
Extended HLA haplotypes in families with insulin‐dependent diabetes mellitus in Northern Finland |
title_sort |
extended hla haplotypes in families with insulin‐dependent diabetes mellitus in northern finland |
publisher |
Wiley |
publishDate |
1988 |
url |
http://dx.doi.org/10.1111/j.1399-0039.1988.tb01649.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1988.tb01649.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1988.tb01649.x |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Tissue Antigens volume 32, issue 3, page 139-144 ISSN 0001-2815 1399-0039 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0039.1988.tb01649.x |
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Tissue Antigens |
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32 |
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3 |
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139 |
op_container_end_page |
144 |
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1800758304106872832 |