HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations
Two newly‐identified HLA‐D antigens were characterized by testing selected homozygous typing cells (HTC) against responder panels derived from Caucasian. Korean, Alaskan Eskimo and Israeli Jewish populations. The first specificity, defined by typing cell “AZH”, is associated with DR2 haplotypes and...
Published in: | Tissue Antigens |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
1984
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/j.1399-0039.1984.tb02127.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1984.tb02127.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1984.tb02127.x |
id |
crwiley:10.1111/j.1399-0039.1984.tb02127.x |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/j.1399-0039.1984.tb02127.x 2024-06-02T08:06:09+00:00 HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations Mickelson, Eric Brautbar, Chaim Nisperos, Brenda Cohen, Nadine Amar, Avraham Kim, Se Jong Lanier, Anne Hansen, John A. 1984 http://dx.doi.org/10.1111/j.1399-0039.1984.tb02127.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1984.tb02127.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1984.tb02127.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Tissue Antigens volume 24, issue 3, page 197-205 ISSN 0001-2815 1399-0039 journal-article 1984 crwiley https://doi.org/10.1111/j.1399-0039.1984.tb02127.x 2024-05-03T10:42:01Z Two newly‐identified HLA‐D antigens were characterized by testing selected homozygous typing cells (HTC) against responder panels derived from Caucasian. Korean, Alaskan Eskimo and Israeli Jewish populations. The first specificity, defined by typing cell “AZH”, is associated with DR2 haplotypes and is detected primarily in Israelis. The second specificity, defined by HTC “TAS”, is associated with DR4 haplotypes and is detected with relatively high frequency in Koreans and Alaskan Eskimos. The data indicate that HTC‐AZH and ‐TAS can be used to identify previously undefined splits or variants of lymphocyte‐defined (LD) determinants associated with DR2 and DR4 haplotypes. Further, the study demonstrates the utility of comparative population analysis in identifying and characterizing alleles encoded by the HLA‐D region and provides additional evidence of heterogeneity within the family of serologically‐defined HLA‐DR haplotypes. Article in Journal/Newspaper eskimo* Wiley Online Library Tissue Antigens 24 3 197 205 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Two newly‐identified HLA‐D antigens were characterized by testing selected homozygous typing cells (HTC) against responder panels derived from Caucasian. Korean, Alaskan Eskimo and Israeli Jewish populations. The first specificity, defined by typing cell “AZH”, is associated with DR2 haplotypes and is detected primarily in Israelis. The second specificity, defined by HTC “TAS”, is associated with DR4 haplotypes and is detected with relatively high frequency in Koreans and Alaskan Eskimos. The data indicate that HTC‐AZH and ‐TAS can be used to identify previously undefined splits or variants of lymphocyte‐defined (LD) determinants associated with DR2 and DR4 haplotypes. Further, the study demonstrates the utility of comparative population analysis in identifying and characterizing alleles encoded by the HLA‐D region and provides additional evidence of heterogeneity within the family of serologically‐defined HLA‐DR haplotypes. |
format |
Article in Journal/Newspaper |
author |
Mickelson, Eric Brautbar, Chaim Nisperos, Brenda Cohen, Nadine Amar, Avraham Kim, Se Jong Lanier, Anne Hansen, John A. |
spellingShingle |
Mickelson, Eric Brautbar, Chaim Nisperos, Brenda Cohen, Nadine Amar, Avraham Kim, Se Jong Lanier, Anne Hansen, John A. HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations |
author_facet |
Mickelson, Eric Brautbar, Chaim Nisperos, Brenda Cohen, Nadine Amar, Avraham Kim, Se Jong Lanier, Anne Hansen, John A. |
author_sort |
Mickelson, Eric |
title |
HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations |
title_short |
HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations |
title_full |
HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations |
title_fullStr |
HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations |
title_full_unstemmed |
HLA‐DR2 and DR4 further defined by two new HLA‐D specificities (HTC) derived from Israeli Jewish donors: comparative study in Caucasian, Korean, Eskimo and Israeli populations |
title_sort |
hla‐dr2 and dr4 further defined by two new hla‐d specificities (htc) derived from israeli jewish donors: comparative study in caucasian, korean, eskimo and israeli populations |
publisher |
Wiley |
publishDate |
1984 |
url |
http://dx.doi.org/10.1111/j.1399-0039.1984.tb02127.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1984.tb02127.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1984.tb02127.x |
genre |
eskimo* |
genre_facet |
eskimo* |
op_source |
Tissue Antigens volume 24, issue 3, page 197-205 ISSN 0001-2815 1399-0039 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0039.1984.tb02127.x |
container_title |
Tissue Antigens |
container_volume |
24 |
container_issue |
3 |
container_start_page |
197 |
op_container_end_page |
205 |
_version_ |
1800751054879457280 |