Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study
In three adjacent Newfoundland communities comprising some 1500 people, 589 people have been HLA typed. Forty‐six of the typed people gave a history of previous clinical tuberculosis which required treatment. Fifty‐six percent of the TB patients carried HLA B8 compared with 20% of the remainder of t...
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crwiley:10.1111/j.1399-0039.1978.tb01275.x 2024-06-02T08:10:40+00:00 Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study Selby, R. Barnard, J. M. Buehler, S. K. Crumley, J. Larsen, B. Marshall, W. H. 1978 http://dx.doi.org/10.1111/j.1399-0039.1978.tb01275.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1978.tb01275.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1978.tb01275.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Tissue Antigens volume 11, issue 5, page 403-408 ISSN 0001-2815 1399-0039 journal-article 1978 crwiley https://doi.org/10.1111/j.1399-0039.1978.tb01275.x 2024-05-03T11:27:55Z In three adjacent Newfoundland communities comprising some 1500 people, 589 people have been HLA typed. Forty‐six of the typed people gave a history of previous clinical tuberculosis which required treatment. Fifty‐six percent of the TB patients carried HLA B8 compared with 20% of the remainder of the population. This is a highly significant difference ( P < 0.01). In each community the frequency of B8 as an epidemiological marker correlated with the incidence of tuberculosis. B8 is associated with TB in this study with a relative risk of 5.2 which compares with combined relative risks in the literature for coeliac disease and Addison's disease of 9.5 and 6.4, respectively, and which is greater than the risks for all the other B8‐related diseases. The factor B allele, Bf S, was found on all the B8 haplotypes, but the overall Bf gene frequencies in tuberculosis patients did not deviate from expected values. Article in Journal/Newspaper Newfoundland Wiley Online Library Tissue Antigens 11 5 403 408 |
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Wiley Online Library |
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crwiley |
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English |
description |
In three adjacent Newfoundland communities comprising some 1500 people, 589 people have been HLA typed. Forty‐six of the typed people gave a history of previous clinical tuberculosis which required treatment. Fifty‐six percent of the TB patients carried HLA B8 compared with 20% of the remainder of the population. This is a highly significant difference ( P < 0.01). In each community the frequency of B8 as an epidemiological marker correlated with the incidence of tuberculosis. B8 is associated with TB in this study with a relative risk of 5.2 which compares with combined relative risks in the literature for coeliac disease and Addison's disease of 9.5 and 6.4, respectively, and which is greater than the risks for all the other B8‐related diseases. The factor B allele, Bf S, was found on all the B8 haplotypes, but the overall Bf gene frequencies in tuberculosis patients did not deviate from expected values. |
format |
Article in Journal/Newspaper |
author |
Selby, R. Barnard, J. M. Buehler, S. K. Crumley, J. Larsen, B. Marshall, W. H. |
spellingShingle |
Selby, R. Barnard, J. M. Buehler, S. K. Crumley, J. Larsen, B. Marshall, W. H. Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study |
author_facet |
Selby, R. Barnard, J. M. Buehler, S. K. Crumley, J. Larsen, B. Marshall, W. H. |
author_sort |
Selby, R. |
title |
Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study |
title_short |
Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study |
title_full |
Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study |
title_fullStr |
Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study |
title_full_unstemmed |
Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study |
title_sort |
tuberculosis associated with hla—b8, bf s in a newfoundland community study |
publisher |
Wiley |
publishDate |
1978 |
url |
http://dx.doi.org/10.1111/j.1399-0039.1978.tb01275.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1978.tb01275.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1978.tb01275.x |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Tissue Antigens volume 11, issue 5, page 403-408 ISSN 0001-2815 1399-0039 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0039.1978.tb01275.x |
container_title |
Tissue Antigens |
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11 |
container_issue |
5 |
container_start_page |
403 |
op_container_end_page |
408 |
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1800756567798185984 |