Genetic epidemiology of Greenland
The Inuit (Eskimo) gene pool is in many respects similar to that of East Asian populations. Some polymorphisms imply frequent occurrence of disorders comparatively rare in Western Europe (e.g. lactose and sucrose malabsorptions). Low frequencies of alleles for slow isoniazid acetylation and spartein...
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crwiley:10.1111/j.1399-0004.1989.tb03214.x 2024-06-02T08:02:06+00:00 Genetic epidemiology of Greenland Harvald, Bent 1989 http://dx.doi.org/10.1111/j.1399-0004.1989.tb03214.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0004.1989.tb03214.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0004.1989.tb03214.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Clinical Genetics volume 36, issue 5, page 364-367 ISSN 0009-9163 1399-0004 journal-article 1989 crwiley https://doi.org/10.1111/j.1399-0004.1989.tb03214.x 2024-05-06T07:00:04Z The Inuit (Eskimo) gene pool is in many respects similar to that of East Asian populations. Some polymorphisms imply frequent occurrence of disorders comparatively rare in Western Europe (e.g. lactose and sucrose malabsorptions). Low frequencies of alleles for slow isoniazid acetylation and sparteine/debrisoquine oxidation indicate slow elimination of a multitude of drugs. Autoimmune disorders (e.g. rheumatoid arthritis, insulin‐dependent diabetes mellitus, Graves' disease and psoriasis) are rare, possibly explained by the associations of these disorders with HLA‐alleles rare in the Inuit (e.g. HLA‐B8). A correspondingly high incidence of reactive arthritis may be explained by a frequent HLA‐B27 allele. The prevalence of disorders due to instability of mesenchymal tissues (e.g. spondylolisthesis, osteoarthrosis, hernia, heart block) still requires a biochemical explanation. Attention is drawn to the urgency of genetic studies in the Arctic because of the accelerating hybridization of the Inuit in all circumpolar areas. Article in Journal/Newspaper Arctic eskimo* Greenland inuit Wiley Online Library Arctic Greenland Clinical Genetics 36 5 364 367 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
The Inuit (Eskimo) gene pool is in many respects similar to that of East Asian populations. Some polymorphisms imply frequent occurrence of disorders comparatively rare in Western Europe (e.g. lactose and sucrose malabsorptions). Low frequencies of alleles for slow isoniazid acetylation and sparteine/debrisoquine oxidation indicate slow elimination of a multitude of drugs. Autoimmune disorders (e.g. rheumatoid arthritis, insulin‐dependent diabetes mellitus, Graves' disease and psoriasis) are rare, possibly explained by the associations of these disorders with HLA‐alleles rare in the Inuit (e.g. HLA‐B8). A correspondingly high incidence of reactive arthritis may be explained by a frequent HLA‐B27 allele. The prevalence of disorders due to instability of mesenchymal tissues (e.g. spondylolisthesis, osteoarthrosis, hernia, heart block) still requires a biochemical explanation. Attention is drawn to the urgency of genetic studies in the Arctic because of the accelerating hybridization of the Inuit in all circumpolar areas. |
format |
Article in Journal/Newspaper |
author |
Harvald, Bent |
spellingShingle |
Harvald, Bent Genetic epidemiology of Greenland |
author_facet |
Harvald, Bent |
author_sort |
Harvald, Bent |
title |
Genetic epidemiology of Greenland |
title_short |
Genetic epidemiology of Greenland |
title_full |
Genetic epidemiology of Greenland |
title_fullStr |
Genetic epidemiology of Greenland |
title_full_unstemmed |
Genetic epidemiology of Greenland |
title_sort |
genetic epidemiology of greenland |
publisher |
Wiley |
publishDate |
1989 |
url |
http://dx.doi.org/10.1111/j.1399-0004.1989.tb03214.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0004.1989.tb03214.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0004.1989.tb03214.x |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic eskimo* Greenland inuit |
genre_facet |
Arctic eskimo* Greenland inuit |
op_source |
Clinical Genetics volume 36, issue 5, page 364-367 ISSN 0009-9163 1399-0004 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0004.1989.tb03214.x |
container_title |
Clinical Genetics |
container_volume |
36 |
container_issue |
5 |
container_start_page |
364 |
op_container_end_page |
367 |
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1800746593640513536 |