Nonketotic hyperglycinemia A genetic study of 13 Finnish families
In Finland, 19 children, born 1964–1977, from 13 families, have been diagnosed as suffering from nonketotic hyperglycinemia (NKH). This gives an incidence for NKH in the Finnish population of 1:55,000 newborns. The majority of these children were born in the northern part of the country, where the i...
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crwiley:10.1111/j.1399-0004.1979.tb01773.x 2024-06-02T08:12:01+00:00 Nonketotic hyperglycinemia A genetic study of 13 Finnish families Wendt, L. V. Hirvasniemi, A. Similä, S. 1979 http://dx.doi.org/10.1111/j.1399-0004.1979.tb01773.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0004.1979.tb01773.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0004.1979.tb01773.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Clinical Genetics volume 15, issue 5, page 411-417 ISSN 0009-9163 1399-0004 journal-article 1979 crwiley https://doi.org/10.1111/j.1399-0004.1979.tb01773.x 2024-05-03T11:42:26Z In Finland, 19 children, born 1964–1977, from 13 families, have been diagnosed as suffering from nonketotic hyperglycinemia (NKH). This gives an incidence for NKH in the Finnish population of 1:55,000 newborns. The majority of these children were born in the northern part of the country, where the incidence is 1:12,000. The geographical distribution of the birth‐places of the grandparents also seems to point towards an enrichment of the gene in northern Finland. An autosomal recessive mode of inheritance for this disease seems probable, since the corrected proportion of affected siblings (Apert's a priori method) is 0.288. Abnormally high plasma glycine concentration and elevated glycine urinary excretion in the parents of the NKH‐children suggest the existence of a minor metabolic defect in heterozygotes of this disease. Some of the healthy siblings of the NKH‐patients also show similary elevated levels. However, a definite diagnosis of the NKH‐heterozygote state cannot easily be made on the basis of these laboratory findings, as the levels in some individuals are very close to, or even overlap corresponding values in a normal material. Article in Journal/Newspaper Northern Finland Wiley Online Library Clinical Genetics 15 5 411 417 |
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Wiley Online Library |
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crwiley |
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English |
description |
In Finland, 19 children, born 1964–1977, from 13 families, have been diagnosed as suffering from nonketotic hyperglycinemia (NKH). This gives an incidence for NKH in the Finnish population of 1:55,000 newborns. The majority of these children were born in the northern part of the country, where the incidence is 1:12,000. The geographical distribution of the birth‐places of the grandparents also seems to point towards an enrichment of the gene in northern Finland. An autosomal recessive mode of inheritance for this disease seems probable, since the corrected proportion of affected siblings (Apert's a priori method) is 0.288. Abnormally high plasma glycine concentration and elevated glycine urinary excretion in the parents of the NKH‐children suggest the existence of a minor metabolic defect in heterozygotes of this disease. Some of the healthy siblings of the NKH‐patients also show similary elevated levels. However, a definite diagnosis of the NKH‐heterozygote state cannot easily be made on the basis of these laboratory findings, as the levels in some individuals are very close to, or even overlap corresponding values in a normal material. |
format |
Article in Journal/Newspaper |
author |
Wendt, L. V. Hirvasniemi, A. Similä, S. |
spellingShingle |
Wendt, L. V. Hirvasniemi, A. Similä, S. Nonketotic hyperglycinemia A genetic study of 13 Finnish families |
author_facet |
Wendt, L. V. Hirvasniemi, A. Similä, S. |
author_sort |
Wendt, L. V. |
title |
Nonketotic hyperglycinemia A genetic study of 13 Finnish families |
title_short |
Nonketotic hyperglycinemia A genetic study of 13 Finnish families |
title_full |
Nonketotic hyperglycinemia A genetic study of 13 Finnish families |
title_fullStr |
Nonketotic hyperglycinemia A genetic study of 13 Finnish families |
title_full_unstemmed |
Nonketotic hyperglycinemia A genetic study of 13 Finnish families |
title_sort |
nonketotic hyperglycinemia a genetic study of 13 finnish families |
publisher |
Wiley |
publishDate |
1979 |
url |
http://dx.doi.org/10.1111/j.1399-0004.1979.tb01773.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0004.1979.tb01773.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0004.1979.tb01773.x |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Clinical Genetics volume 15, issue 5, page 411-417 ISSN 0009-9163 1399-0004 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1399-0004.1979.tb01773.x |
container_title |
Clinical Genetics |
container_volume |
15 |
container_issue |
5 |
container_start_page |
411 |
op_container_end_page |
417 |
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1800758337894088704 |