Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein
Summary A fraction isolated by electrofocusing (pI 4.2) from a saline extract of the turbot parasite. Bothriocephalus scorpii , contained choline and precipitated with a teleost C‐reactive protein (CRP) and a phosphorylcholine‐binding Balb/c mouse myeloma protein, TEPC‐15. Non‐dialysable products re...
Published in: | Parasite Immunology |
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Language: | English |
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1980
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crwiley:10.1111/j.1365-3024.1980.tb00056.x 2024-06-02T08:15:29+00:00 Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein FLETCHER, THELMA C. WHITE, ANN BALDO, B.A. 1980 http://dx.doi.org/10.1111/j.1365-3024.1980.tb00056.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-3024.1980.tb00056.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-3024.1980.tb00056.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Parasite Immunology volume 2, issue 4, page 237-248 ISSN 0141-9838 1365-3024 journal-article 1980 crwiley https://doi.org/10.1111/j.1365-3024.1980.tb00056.x 2024-05-03T11:37:22Z Summary A fraction isolated by electrofocusing (pI 4.2) from a saline extract of the turbot parasite. Bothriocephalus scorpii , contained choline and precipitated with a teleost C‐reactive protein (CRP) and a phosphorylcholine‐binding Balb/c mouse myeloma protein, TEPC‐15. Non‐dialysable products released from cultured tapeworms also precipitated with the phosphorylcholine‐specific precipitins. Ca 2+ was required for precipitation with CRP and immunodiffusion lines were confluent with pneumococcal C‐polysaccharide and a fungal C substance. Intradermal injection of the phosphorylcholine‐containing fraction caused an immediate erythema reaction in all mature turbot tested. The skin reaction is thought to be related to the amount of circulating CRP and this protein was present in sera from all mature turbot giving a positive skin response. There is no evidence for CRP being toxic to the tapeworms and the possibility is discussed that the worms exploit the host CRP for their own survival. Article in Journal/Newspaper Turbot Wiley Online Library Parasite Immunology 2 4 237 248 |
institution |
Open Polar |
collection |
Wiley Online Library |
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crwiley |
language |
English |
description |
Summary A fraction isolated by electrofocusing (pI 4.2) from a saline extract of the turbot parasite. Bothriocephalus scorpii , contained choline and precipitated with a teleost C‐reactive protein (CRP) and a phosphorylcholine‐binding Balb/c mouse myeloma protein, TEPC‐15. Non‐dialysable products released from cultured tapeworms also precipitated with the phosphorylcholine‐specific precipitins. Ca 2+ was required for precipitation with CRP and immunodiffusion lines were confluent with pneumococcal C‐polysaccharide and a fungal C substance. Intradermal injection of the phosphorylcholine‐containing fraction caused an immediate erythema reaction in all mature turbot tested. The skin reaction is thought to be related to the amount of circulating CRP and this protein was present in sera from all mature turbot giving a positive skin response. There is no evidence for CRP being toxic to the tapeworms and the possibility is discussed that the worms exploit the host CRP for their own survival. |
format |
Article in Journal/Newspaper |
author |
FLETCHER, THELMA C. WHITE, ANN BALDO, B.A. |
spellingShingle |
FLETCHER, THELMA C. WHITE, ANN BALDO, B.A. Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein |
author_facet |
FLETCHER, THELMA C. WHITE, ANN BALDO, B.A. |
author_sort |
FLETCHER, THELMA C. |
title |
Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein |
title_short |
Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein |
title_full |
Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein |
title_fullStr |
Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein |
title_full_unstemmed |
Isolation of a phosphorylcholine‐containing component from the turbot tapeworm, Bothriocephalus scorpii (Müller), and its reaction with C‐reactive protein |
title_sort |
isolation of a phosphorylcholine‐containing component from the turbot tapeworm, bothriocephalus scorpii (müller), and its reaction with c‐reactive protein |
publisher |
Wiley |
publishDate |
1980 |
url |
http://dx.doi.org/10.1111/j.1365-3024.1980.tb00056.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-3024.1980.tb00056.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-3024.1980.tb00056.x |
genre |
Turbot |
genre_facet |
Turbot |
op_source |
Parasite Immunology volume 2, issue 4, page 237-248 ISSN 0141-9838 1365-3024 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-3024.1980.tb00056.x |
container_title |
Parasite Immunology |
container_volume |
2 |
container_issue |
4 |
container_start_page |
237 |
op_container_end_page |
248 |
_version_ |
1800739670636625920 |