Viliuisk encephalomyelitis — review of the spectrum of pathological changes
Viliuisk encephalomyelitis (VE) is an unique neurological disease occurring in the Iakut (Sakha) people of Siberia. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Death occurs within 3 to 6 months in subacute cases and within 6 years in t...
Published in: | Neuropathology and Applied Neurobiology |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
1997
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/j.1365-2990.1997.tb01204.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2990.1997.tb01204.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2990.1997.tb01204.x |
id |
crwiley:10.1111/j.1365-2990.1997.tb01204.x |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/j.1365-2990.1997.tb01204.x 2024-06-02T08:13:53+00:00 Viliuisk encephalomyelitis — review of the spectrum of pathological changes McLean, C. A. Vladimirtsev, V. A. Prokhorova, I. A. Goldfarb, L. G. Asher, D. M. Vladimirtsev, A. I. Alekseev, V. P. Gajdusek, D. C. 1997 http://dx.doi.org/10.1111/j.1365-2990.1997.tb01204.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2990.1997.tb01204.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2990.1997.tb01204.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Neuropathology and Applied Neurobiology volume 23, issue 3, page 212-217 ISSN 0305-1846 1365-2990 journal-article 1997 crwiley https://doi.org/10.1111/j.1365-2990.1997.tb01204.x 2024-05-03T11:17:31Z Viliuisk encephalomyelitis (VE) is an unique neurological disease occurring in the Iakut (Sakha) people of Siberia. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Death occurs within 3 to 6 months in subacute cases and within 6 years in the slowly progressive cases. Chronic cases lack a subacute phase but show a slowly progressive dementia associated with bradykinesia, dysarthria and spastic paraparesis that stabilizes late in the disease process. In subacute and slowly progressive cases, focal necrotizing encephalomyelitis is seen at necropsy. Chronic cases show multifocal areas of lysis with a gliotic margin, predominantly within grey matter, lacking associated chronic inflammatory changes seen in the other forms of the disease. Epidemiological studies are consistent with a disease of low‐grade communicability, but laboratory studies have so far failed to reveal an infectious organism. The spectrum of neuropathological changes are reviewed in this examination of 11 cases. Although the aetiology of VE remains obscure, further studies are warranted since it may represent a novel disease process. Article in Journal/Newspaper Sakha Siberia Wiley Online Library Sakha Neuropathology and Applied Neurobiology 23 3 212 217 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Viliuisk encephalomyelitis (VE) is an unique neurological disease occurring in the Iakut (Sakha) people of Siberia. Evolution of the disease follows one of three broad clinical forms: subacute, slowly progressive or chronic. Death occurs within 3 to 6 months in subacute cases and within 6 years in the slowly progressive cases. Chronic cases lack a subacute phase but show a slowly progressive dementia associated with bradykinesia, dysarthria and spastic paraparesis that stabilizes late in the disease process. In subacute and slowly progressive cases, focal necrotizing encephalomyelitis is seen at necropsy. Chronic cases show multifocal areas of lysis with a gliotic margin, predominantly within grey matter, lacking associated chronic inflammatory changes seen in the other forms of the disease. Epidemiological studies are consistent with a disease of low‐grade communicability, but laboratory studies have so far failed to reveal an infectious organism. The spectrum of neuropathological changes are reviewed in this examination of 11 cases. Although the aetiology of VE remains obscure, further studies are warranted since it may represent a novel disease process. |
format |
Article in Journal/Newspaper |
author |
McLean, C. A. Vladimirtsev, V. A. Prokhorova, I. A. Goldfarb, L. G. Asher, D. M. Vladimirtsev, A. I. Alekseev, V. P. Gajdusek, D. C. |
spellingShingle |
McLean, C. A. Vladimirtsev, V. A. Prokhorova, I. A. Goldfarb, L. G. Asher, D. M. Vladimirtsev, A. I. Alekseev, V. P. Gajdusek, D. C. Viliuisk encephalomyelitis — review of the spectrum of pathological changes |
author_facet |
McLean, C. A. Vladimirtsev, V. A. Prokhorova, I. A. Goldfarb, L. G. Asher, D. M. Vladimirtsev, A. I. Alekseev, V. P. Gajdusek, D. C. |
author_sort |
McLean, C. A. |
title |
Viliuisk encephalomyelitis — review of the spectrum of pathological changes |
title_short |
Viliuisk encephalomyelitis — review of the spectrum of pathological changes |
title_full |
Viliuisk encephalomyelitis — review of the spectrum of pathological changes |
title_fullStr |
Viliuisk encephalomyelitis — review of the spectrum of pathological changes |
title_full_unstemmed |
Viliuisk encephalomyelitis — review of the spectrum of pathological changes |
title_sort |
viliuisk encephalomyelitis — review of the spectrum of pathological changes |
publisher |
Wiley |
publishDate |
1997 |
url |
http://dx.doi.org/10.1111/j.1365-2990.1997.tb01204.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2990.1997.tb01204.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2990.1997.tb01204.x |
geographic |
Sakha |
geographic_facet |
Sakha |
genre |
Sakha Siberia |
genre_facet |
Sakha Siberia |
op_source |
Neuropathology and Applied Neurobiology volume 23, issue 3, page 212-217 ISSN 0305-1846 1365-2990 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2990.1997.tb01204.x |
container_title |
Neuropathology and Applied Neurobiology |
container_volume |
23 |
container_issue |
3 |
container_start_page |
212 |
op_container_end_page |
217 |
_version_ |
1800737529212698624 |