Resistance to abomasal nematodes and individual genetic variability in reindeer
Abstract Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess...
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crwiley:10.1111/j.1365-294x.2005.02733.x 2024-06-02T08:13:38+00:00 Resistance to abomasal nematodes and individual genetic variability in reindeer CÔTÉ, STEEVE D. STIEN, AUDUN IRVINE, R. JUSTIN DALLAS, JOHN F. MARSHALL, FREDA HALVORSEN, ODD LANGVATN, ROLF ALBON, STEVE D. 2005 http://dx.doi.org/10.1111/j.1365-294x.2005.02733.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-294X.2005.02733.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-294X.2005.02733.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Ecology volume 14, issue 13, page 4159-4168 ISSN 0962-1083 1365-294X journal-article 2005 crwiley https://doi.org/10.1111/j.1365-294x.2005.02733.x 2024-05-03T11:30:01Z Abstract Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess the relationships between genomewide individual heterozygosity and abomasal nematode burdens in female Svalbard reindeer ( Rangifer tarandus platyrhynchus ) after the effects of host age, locality, season, and year had been accounted for. Samples were obtained from 306 female reindeer that were culled and genotyped at nine microsatellite loci. Reindeer in our study populations are mainly parasitized by the gastrointestinal nematodes Ostertagia gruehneri and Marshallagia marshalli . The infection intensity of each parasite differed between subpopulations, and among host age classes, seasons and years. We found no significant relationships between abomasal worm burdens, or lumen and mucosa larvae, of either O . gruehneri or M . marshalli and individual heterozygosity (or mean d 2 ) alone or in interactions with host age, locality, and year. Although we analysed one of the largest data set available to date on gastrointestinal nematodes of a wild ruminant, we used a typical data set of nine genetic neutral markers that may have had low power to detect heterozygosity–fitness correlations. We conclude that the proportion of the variance in parasite resistance explained by individual heterozygosity for neutral genetic markers is low in Svalbard reindeer and in vertebrates in general, and we suggest that the candidate‐gene approach might be more fruitful for further research on gene–fitness correlations. Article in Journal/Newspaper Rangifer tarandus Rangifer tarandus platyrhynchus Svalbard svalbard reindeer Wiley Online Library Svalbard Molecular Ecology 14 13 4159 4168 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract Resistance to parasites is believed to have a widespread influence on demographic and adaptive processes. In systems where parasites impose a fitness cost on their host, heterozygotes may be selected because they are more resistant to parasites than homozygotes. Our objective was to assess the relationships between genomewide individual heterozygosity and abomasal nematode burdens in female Svalbard reindeer ( Rangifer tarandus platyrhynchus ) after the effects of host age, locality, season, and year had been accounted for. Samples were obtained from 306 female reindeer that were culled and genotyped at nine microsatellite loci. Reindeer in our study populations are mainly parasitized by the gastrointestinal nematodes Ostertagia gruehneri and Marshallagia marshalli . The infection intensity of each parasite differed between subpopulations, and among host age classes, seasons and years. We found no significant relationships between abomasal worm burdens, or lumen and mucosa larvae, of either O . gruehneri or M . marshalli and individual heterozygosity (or mean d 2 ) alone or in interactions with host age, locality, and year. Although we analysed one of the largest data set available to date on gastrointestinal nematodes of a wild ruminant, we used a typical data set of nine genetic neutral markers that may have had low power to detect heterozygosity–fitness correlations. We conclude that the proportion of the variance in parasite resistance explained by individual heterozygosity for neutral genetic markers is low in Svalbard reindeer and in vertebrates in general, and we suggest that the candidate‐gene approach might be more fruitful for further research on gene–fitness correlations. |
format |
Article in Journal/Newspaper |
author |
CÔTÉ, STEEVE D. STIEN, AUDUN IRVINE, R. JUSTIN DALLAS, JOHN F. MARSHALL, FREDA HALVORSEN, ODD LANGVATN, ROLF ALBON, STEVE D. |
spellingShingle |
CÔTÉ, STEEVE D. STIEN, AUDUN IRVINE, R. JUSTIN DALLAS, JOHN F. MARSHALL, FREDA HALVORSEN, ODD LANGVATN, ROLF ALBON, STEVE D. Resistance to abomasal nematodes and individual genetic variability in reindeer |
author_facet |
CÔTÉ, STEEVE D. STIEN, AUDUN IRVINE, R. JUSTIN DALLAS, JOHN F. MARSHALL, FREDA HALVORSEN, ODD LANGVATN, ROLF ALBON, STEVE D. |
author_sort |
CÔTÉ, STEEVE D. |
title |
Resistance to abomasal nematodes and individual genetic variability in reindeer |
title_short |
Resistance to abomasal nematodes and individual genetic variability in reindeer |
title_full |
Resistance to abomasal nematodes and individual genetic variability in reindeer |
title_fullStr |
Resistance to abomasal nematodes and individual genetic variability in reindeer |
title_full_unstemmed |
Resistance to abomasal nematodes and individual genetic variability in reindeer |
title_sort |
resistance to abomasal nematodes and individual genetic variability in reindeer |
publisher |
Wiley |
publishDate |
2005 |
url |
http://dx.doi.org/10.1111/j.1365-294x.2005.02733.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-294X.2005.02733.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-294X.2005.02733.x |
geographic |
Svalbard |
geographic_facet |
Svalbard |
genre |
Rangifer tarandus Rangifer tarandus platyrhynchus Svalbard svalbard reindeer |
genre_facet |
Rangifer tarandus Rangifer tarandus platyrhynchus Svalbard svalbard reindeer |
op_source |
Molecular Ecology volume 14, issue 13, page 4159-4168 ISSN 0962-1083 1365-294X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-294x.2005.02733.x |
container_title |
Molecular Ecology |
container_volume |
14 |
container_issue |
13 |
container_start_page |
4159 |
op_container_end_page |
4168 |
_version_ |
1800737209697959936 |