Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway

Summary. Knowledge of the natural course and especially the total and cause‐specific mortality of community‐acquired chronic HCV infection is limited. The aims of our study were to determine the total and cause‐specific mortality in patients infected with chronic hepatitis C in a community‐based set...

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Published in:Journal of Viral Hepatitis
Main Authors: Kristiansen, M. G., Løchen, M. ‐L., Gutteberg, T. J., Mortensen, L., Eriksen, B. O., Florholmen, J.
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2011
Subjects:
Online Access:http://dx.doi.org/10.1111/j.1365-2893.2010.01290.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2893.2010.01290.x
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spelling crwiley:10.1111/j.1365-2893.2010.01290.x 2024-06-02T08:12:05+00:00 Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway Kristiansen, M. G. Løchen, M. ‐L. Gutteberg, T. J. Mortensen, L. Eriksen, B. O. Florholmen, J. 2011 http://dx.doi.org/10.1111/j.1365-2893.2010.01290.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2893.2010.01290.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2893.2010.01290.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Viral Hepatitis volume 18, issue 4, page 237-244 ISSN 1352-0504 1365-2893 journal-article 2011 crwiley https://doi.org/10.1111/j.1365-2893.2010.01290.x 2024-05-03T11:46:01Z Summary. Knowledge of the natural course and especially the total and cause‐specific mortality of community‐acquired chronic HCV infection is limited. The aims of our study were to determine the total and cause‐specific mortality in patients infected with chronic hepatitis C in a community‐based setting in northern Norway. This prospective cohort study included 1010 HCV‐positive patients diagnosed with recombinant immunoblot assay between 1 January 1990 and 1 January 2000, with a median observation time from diagnosis to follow‐up of 7 years. Data were collected from medical records in the period between 1 January 2004 and 30 June 2006. Time and cause of death were ascertained from the Norwegian Causes of Death Register. Age‐adjusted death rates and standardised mortality ratios (SMRs) were compared with those of the general Norwegian population. In total, 122 deaths were recorded. The Kaplan–Meier estimate of survival was 88% at 14 years. The SMR in the cohort relative to the general population was 6.66. Most of the excess deaths in both genders were because of liver‐related causes, those associated with a drug‐using lifestyle and suicide. The statistically significant increase in SMRs ranged from 4.2 for death by cancer in women to 64.6 for liver disease in women. There was no statistically significant increase in SMRs from cardiovascular disease in either gender or from cancer in men. In conclusion, our study shows that the death rate in patients infected with hepatitis C is 6.66 times higher than in the general Norwegian population. Article in Journal/Newspaper Northern Norway Wiley Online Library Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Norway Journal of Viral Hepatitis 18 4 237 244
institution Open Polar
collection Wiley Online Library
op_collection_id crwiley
language English
description Summary. Knowledge of the natural course and especially the total and cause‐specific mortality of community‐acquired chronic HCV infection is limited. The aims of our study were to determine the total and cause‐specific mortality in patients infected with chronic hepatitis C in a community‐based setting in northern Norway. This prospective cohort study included 1010 HCV‐positive patients diagnosed with recombinant immunoblot assay between 1 January 1990 and 1 January 2000, with a median observation time from diagnosis to follow‐up of 7 years. Data were collected from medical records in the period between 1 January 2004 and 30 June 2006. Time and cause of death were ascertained from the Norwegian Causes of Death Register. Age‐adjusted death rates and standardised mortality ratios (SMRs) were compared with those of the general Norwegian population. In total, 122 deaths were recorded. The Kaplan–Meier estimate of survival was 88% at 14 years. The SMR in the cohort relative to the general population was 6.66. Most of the excess deaths in both genders were because of liver‐related causes, those associated with a drug‐using lifestyle and suicide. The statistically significant increase in SMRs ranged from 4.2 for death by cancer in women to 64.6 for liver disease in women. There was no statistically significant increase in SMRs from cardiovascular disease in either gender or from cancer in men. In conclusion, our study shows that the death rate in patients infected with hepatitis C is 6.66 times higher than in the general Norwegian population.
format Article in Journal/Newspaper
author Kristiansen, M. G.
Løchen, M. ‐L.
Gutteberg, T. J.
Mortensen, L.
Eriksen, B. O.
Florholmen, J.
spellingShingle Kristiansen, M. G.
Løchen, M. ‐L.
Gutteberg, T. J.
Mortensen, L.
Eriksen, B. O.
Florholmen, J.
Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway
author_facet Kristiansen, M. G.
Løchen, M. ‐L.
Gutteberg, T. J.
Mortensen, L.
Eriksen, B. O.
Florholmen, J.
author_sort Kristiansen, M. G.
title Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway
title_short Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway
title_full Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway
title_fullStr Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway
title_full_unstemmed Total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis C virus infection in northern Norway
title_sort total and cause‐specific mortality rates in a prospective study of community‐acquired hepatitis c virus infection in northern norway
publisher Wiley
publishDate 2011
url http://dx.doi.org/10.1111/j.1365-2893.2010.01290.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2893.2010.01290.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2893.2010.01290.x
long_lat ENVELOPE(-45.900,-45.900,-60.633,-60.633)
geographic Meier
Norway
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genre Northern Norway
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op_source Journal of Viral Hepatitis
volume 18, issue 4, page 237-244
ISSN 1352-0504 1365-2893
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op_doi https://doi.org/10.1111/j.1365-2893.2010.01290.x
container_title Journal of Viral Hepatitis
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