Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L.
Abstract This study examined the efficacy of bithionol as a prophylactic or therapeutic oral treatment for Atlantic salmon (AS), Salmo salar , affected by amoebic gill disease (AGD). Furthermore, it explored the interaction of bithionol oral therapy with the current standard treatment (a freshwater...
Published in: | Journal of Fish Diseases |
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Online Access: | http://dx.doi.org/10.1111/j.1365-2761.2008.01001.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.01001.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.01001.x |
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crwiley:10.1111/j.1365-2761.2008.01001.x 2024-06-02T08:03:36+00:00 Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. Florent, R L Becker, J Powell, M D 2009 http://dx.doi.org/10.1111/j.1365-2761.2008.01001.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.01001.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.01001.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 32, issue 5, page 391-400 ISSN 0140-7775 1365-2761 journal-article 2009 crwiley https://doi.org/10.1111/j.1365-2761.2008.01001.x 2024-05-03T11:20:24Z Abstract This study examined the efficacy of bithionol as a prophylactic or therapeutic oral treatment for Atlantic salmon (AS), Salmo salar , affected by amoebic gill disease (AGD). Furthermore, it explored the interaction of bithionol oral therapy with the current standard treatment (a freshwater bath for at least 3 h). The efficacy of three medicated feeds was determined in the trial by feeding AGD‐affected AS at 1% body weight (BW) day −1 either oil coated commercial feed (control) or prophylactic and therapeutic bithionol at 25 mg kg −1 feed. Feeding commenced 2 weeks prior to exposure to Neoparamoeba spp. at 300 cells L −1 and continued for 49 days post‐exposure (PE). Bithionol when fed as a 2‐week prophylactic or therapeutic treatment at 25 mg kg −1 feed delayed the onset of AGD pathology and reduced the percentage of gill filaments with lesions. Administration of a 3‐h freshwater bath at 28 days PE significantly reduced amoeba numbers to a similar level across all treatments; in contrast, gross gill score and percent lesioned filaments were reduced to different extents, the control having a significantly higher score than both bithionol treatments. Following the freshwater bath, clinical signs of AGD increased at a similar level across all treatments, albeit controls were significantly higher than the bithionol treatments immediately following freshwater treatment. This study demonstrated that bithionol at 25 mg kg −1 feed, when fed as a 2‐week prophylactic or a therapeutic treatment, delayed and reduced the intensity of AGD pathology and warrants further investigation as a treatment for AGD‐affected AS. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Journal of Fish Diseases 32 5 391 400 |
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Open Polar |
collection |
Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract This study examined the efficacy of bithionol as a prophylactic or therapeutic oral treatment for Atlantic salmon (AS), Salmo salar , affected by amoebic gill disease (AGD). Furthermore, it explored the interaction of bithionol oral therapy with the current standard treatment (a freshwater bath for at least 3 h). The efficacy of three medicated feeds was determined in the trial by feeding AGD‐affected AS at 1% body weight (BW) day −1 either oil coated commercial feed (control) or prophylactic and therapeutic bithionol at 25 mg kg −1 feed. Feeding commenced 2 weeks prior to exposure to Neoparamoeba spp. at 300 cells L −1 and continued for 49 days post‐exposure (PE). Bithionol when fed as a 2‐week prophylactic or therapeutic treatment at 25 mg kg −1 feed delayed the onset of AGD pathology and reduced the percentage of gill filaments with lesions. Administration of a 3‐h freshwater bath at 28 days PE significantly reduced amoeba numbers to a similar level across all treatments; in contrast, gross gill score and percent lesioned filaments were reduced to different extents, the control having a significantly higher score than both bithionol treatments. Following the freshwater bath, clinical signs of AGD increased at a similar level across all treatments, albeit controls were significantly higher than the bithionol treatments immediately following freshwater treatment. This study demonstrated that bithionol at 25 mg kg −1 feed, when fed as a 2‐week prophylactic or a therapeutic treatment, delayed and reduced the intensity of AGD pathology and warrants further investigation as a treatment for AGD‐affected AS. |
format |
Article in Journal/Newspaper |
author |
Florent, R L Becker, J Powell, M D |
spellingShingle |
Florent, R L Becker, J Powell, M D Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. |
author_facet |
Florent, R L Becker, J Powell, M D |
author_sort |
Florent, R L |
title |
Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. |
title_short |
Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. |
title_full |
Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. |
title_fullStr |
Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. |
title_full_unstemmed |
Further development of bithionol therapy as a treatment for amoebic gill disease in Atlantic salmon, Salmo salar L. |
title_sort |
further development of bithionol therapy as a treatment for amoebic gill disease in atlantic salmon, salmo salar l. |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1111/j.1365-2761.2008.01001.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.01001.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.01001.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Fish Diseases volume 32, issue 5, page 391-400 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2761.2008.01001.x |
container_title |
Journal of Fish Diseases |
container_volume |
32 |
container_issue |
5 |
container_start_page |
391 |
op_container_end_page |
400 |
_version_ |
1800748178140561408 |