Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L.
Abstract Infectious salmon anaemia virus (ISAV) surveillance in the Bay of Fundy has identified the existence of a large number of genetically distinct ISAV isolates which appear to be of variable virulence. Genetically distinct isolates are currently being designated based on sequencing of the hype...
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crwiley:10.1111/j.1365-2761.2008.00973.x 2024-04-28T08:13:45+00:00 Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. Ritchie, R J McDonald, J T Glebe, B Young‐Lai, W Johnsen, E Gagné, N 2009 http://dx.doi.org/10.1111/j.1365-2761.2008.00973.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.00973.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.00973.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 32, issue 2, page 157-171 ISSN 0140-7775 1365-2761 Veterinary (miscellaneous) Aquatic Science journal-article 2009 crwiley https://doi.org/10.1111/j.1365-2761.2008.00973.x 2024-04-05T07:40:18Z Abstract Infectious salmon anaemia virus (ISAV) surveillance in the Bay of Fundy has identified the existence of a large number of genetically distinct ISAV isolates which appear to be of variable virulence. Genetically distinct isolates are currently being designated based on sequencing of the hyper polymorphic region (HPR) of genomic segment 6, which encodes the haemagglutinin–esterase protein, but it has been difficult to elucidate a clear association between these molecular variations and variations in virulence. This has hampered the establishment of proactive management decisions regarding infected fish, and ISAV infections, regardless of type, must be treated as one. Field data of ISAV infections is difficult to collect and to compare between infections because of a wide range of confounding factors including time of year, fish stock, cage site location, mitigating factors and stressors. An important tool in determining the relationship between molecular differences and virulence comes from analysis of quarantine studies. The goal of this study was to compare the virulence, by co‐habitation and intraperitoneal injection, of four regionally common and recent ISAV isolates in a controlled environment. We found significant differences in mortality between ISAV molecular isolates, and present data showing that survival of ISAV infection confers significant resistance to re‐infection with a different ISAV isolate. These findings, if borne out in field studies, will significantly alter the way ISAV infections are managed in the Bay of Fundy and elsewhere. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Journal of Fish Diseases 32 2 157 171 |
institution |
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Wiley Online Library |
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language |
English |
topic |
Veterinary (miscellaneous) Aquatic Science |
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Veterinary (miscellaneous) Aquatic Science Ritchie, R J McDonald, J T Glebe, B Young‐Lai, W Johnsen, E Gagné, N Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. |
topic_facet |
Veterinary (miscellaneous) Aquatic Science |
description |
Abstract Infectious salmon anaemia virus (ISAV) surveillance in the Bay of Fundy has identified the existence of a large number of genetically distinct ISAV isolates which appear to be of variable virulence. Genetically distinct isolates are currently being designated based on sequencing of the hyper polymorphic region (HPR) of genomic segment 6, which encodes the haemagglutinin–esterase protein, but it has been difficult to elucidate a clear association between these molecular variations and variations in virulence. This has hampered the establishment of proactive management decisions regarding infected fish, and ISAV infections, regardless of type, must be treated as one. Field data of ISAV infections is difficult to collect and to compare between infections because of a wide range of confounding factors including time of year, fish stock, cage site location, mitigating factors and stressors. An important tool in determining the relationship between molecular differences and virulence comes from analysis of quarantine studies. The goal of this study was to compare the virulence, by co‐habitation and intraperitoneal injection, of four regionally common and recent ISAV isolates in a controlled environment. We found significant differences in mortality between ISAV molecular isolates, and present data showing that survival of ISAV infection confers significant resistance to re‐infection with a different ISAV isolate. These findings, if borne out in field studies, will significantly alter the way ISAV infections are managed in the Bay of Fundy and elsewhere. |
format |
Article in Journal/Newspaper |
author |
Ritchie, R J McDonald, J T Glebe, B Young‐Lai, W Johnsen, E Gagné, N |
author_facet |
Ritchie, R J McDonald, J T Glebe, B Young‐Lai, W Johnsen, E Gagné, N |
author_sort |
Ritchie, R J |
title |
Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. |
title_short |
Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. |
title_full |
Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. |
title_fullStr |
Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. |
title_full_unstemmed |
Comparative virulence of Infectious salmon anaemia virus isolates in Atlantic salmon, Salmo salar L. |
title_sort |
comparative virulence of infectious salmon anaemia virus isolates in atlantic salmon, salmo salar l. |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1111/j.1365-2761.2008.00973.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.00973.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.00973.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Fish Diseases volume 32, issue 2, page 157-171 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2761.2008.00973.x |
container_title |
Journal of Fish Diseases |
container_volume |
32 |
container_issue |
2 |
container_start_page |
157 |
op_container_end_page |
171 |
_version_ |
1797580104882192384 |