Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L.
Abstract Two series of experimental challenge trials were performed for evaluation of multivalent oil‐adjuvanted vaccines with and without an infectious pancreatic necrosis virus (IPNV) antigen component. In both the trial series, Atlantic salmon were hatched, reared, vaccinated and subjected to tem...
Published in: | Journal of Fish Diseases |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2008
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/j.1365-2761.2008.00929.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.00929.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.00929.x |
id |
crwiley:10.1111/j.1365-2761.2008.00929.x |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/j.1365-2761.2008.00929.x 2024-06-23T07:51:17+00:00 Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. Ramstad, A Midtlyng, P J 2008 http://dx.doi.org/10.1111/j.1365-2761.2008.00929.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.00929.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.00929.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Diseases volume 31, issue 8, page 567-578 ISSN 0140-7775 1365-2761 journal-article 2008 crwiley https://doi.org/10.1111/j.1365-2761.2008.00929.x 2024-05-31T08:11:31Z Abstract Two series of experimental challenge trials were performed for evaluation of multivalent oil‐adjuvanted vaccines with and without an infectious pancreatic necrosis virus (IPNV) antigen component. In both the trial series, Atlantic salmon were hatched, reared, vaccinated and subjected to temperature and light manipulation to induce smoltification. When ready for sea the fish were transported to the VESO Vikan experimental laboratory for bath or cohabitant challenge with IPNV. In the first series, four vaccination and bath challenge trials involving 2‐year classes of experimental fish were conducted. In the second series, three groups of eyed eggs of Atlantic salmon allegedly differing in their innate resistance to IPNV were used (Storset, Strand, Wetten, Kjøglum & Ramstad 2007). Hatching, rearing and smoltification were synchronized for each group, and fish from each genetic group were randomly allocated IPN vaccine, reference vaccine or saline before being placed into parallel tanks for bath or cohabitant challenge. In the first series of trials, IPN‐specific mortality commenced on day 10–12 after bath challenge. Replicates showed similar results. In trials 1 and 2 belonging to the same experimental fish year class, the average cumulative control mortality reached 60.6% and 79.5%, respectively, whereas in trials 3 and 4 belonging to the following year class the control mortality was consistently below 50%. In the second series of trials, the experimental fish originating from allegedly IPN susceptible parents consistently showed the highest cumulative mortality among the unvaccinated controls (>75%) whereas smolts derived from allegedly IPNV resistant parents showed only 26–35% control mortality. The IPN‐vaccinated fish experienced significantly improved survival vs. the fish immunized with reference vaccine, with RPS values above 75% in the IPN susceptible strain. In the IPN resistant strain, the protection outcomes were variable and in part non‐significant. The outcome of both the trial series ... Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Ramstad ENVELOPE(16.477,16.477,68.539,68.539) Vikan ENVELOPE(14.700,14.700,67.300,67.300) Journal of Fish Diseases 31 8 567 578 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract Two series of experimental challenge trials were performed for evaluation of multivalent oil‐adjuvanted vaccines with and without an infectious pancreatic necrosis virus (IPNV) antigen component. In both the trial series, Atlantic salmon were hatched, reared, vaccinated and subjected to temperature and light manipulation to induce smoltification. When ready for sea the fish were transported to the VESO Vikan experimental laboratory for bath or cohabitant challenge with IPNV. In the first series, four vaccination and bath challenge trials involving 2‐year classes of experimental fish were conducted. In the second series, three groups of eyed eggs of Atlantic salmon allegedly differing in their innate resistance to IPNV were used (Storset, Strand, Wetten, Kjøglum & Ramstad 2007). Hatching, rearing and smoltification were synchronized for each group, and fish from each genetic group were randomly allocated IPN vaccine, reference vaccine or saline before being placed into parallel tanks for bath or cohabitant challenge. In the first series of trials, IPN‐specific mortality commenced on day 10–12 after bath challenge. Replicates showed similar results. In trials 1 and 2 belonging to the same experimental fish year class, the average cumulative control mortality reached 60.6% and 79.5%, respectively, whereas in trials 3 and 4 belonging to the following year class the control mortality was consistently below 50%. In the second series of trials, the experimental fish originating from allegedly IPN susceptible parents consistently showed the highest cumulative mortality among the unvaccinated controls (>75%) whereas smolts derived from allegedly IPNV resistant parents showed only 26–35% control mortality. The IPN‐vaccinated fish experienced significantly improved survival vs. the fish immunized with reference vaccine, with RPS values above 75% in the IPN susceptible strain. In the IPN resistant strain, the protection outcomes were variable and in part non‐significant. The outcome of both the trial series ... |
format |
Article in Journal/Newspaper |
author |
Ramstad, A Midtlyng, P J |
spellingShingle |
Ramstad, A Midtlyng, P J Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. |
author_facet |
Ramstad, A Midtlyng, P J |
author_sort |
Ramstad, A |
title |
Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. |
title_short |
Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. |
title_full |
Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. |
title_fullStr |
Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. |
title_full_unstemmed |
Strong genetic influence on IPN vaccination‐and‐challenge trials in Atlantic salmon, Salmo salar L. |
title_sort |
strong genetic influence on ipn vaccination‐and‐challenge trials in atlantic salmon, salmo salar l. |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1111/j.1365-2761.2008.00929.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2761.2008.00929.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2761.2008.00929.x |
long_lat |
ENVELOPE(16.477,16.477,68.539,68.539) ENVELOPE(14.700,14.700,67.300,67.300) |
geographic |
Ramstad Vikan |
geographic_facet |
Ramstad Vikan |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Fish Diseases volume 31, issue 8, page 567-578 ISSN 0140-7775 1365-2761 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2761.2008.00929.x |
container_title |
Journal of Fish Diseases |
container_volume |
31 |
container_issue |
8 |
container_start_page |
567 |
op_container_end_page |
578 |
_version_ |
1802642336794017792 |