Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians
Summary In Greenland, with a male population of approximately 30 000 individuals, the incidence of prostate cancer is extremely low with only three cases described during the period 1988–1997. Polymorphisms related to high androgen metabolism and/or response in the 5 α ‐reductase type 2 (SRD5A2) and...
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crwiley:10.1111/j.1365-2605.2007.00750.x 2024-06-23T07:53:14+00:00 Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians Giwercman, Charlotte Giwercman, Aleksander Pedersen, Henning Sloth Toft, Gunnar Lundin, Kristina Bonde, Jens‐Peter Giwercman, Yvonne Lundberg 2007 http://dx.doi.org/10.1111/j.1365-2605.2007.00750.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2605.2007.00750.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2605.2007.00750.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Andrology volume 31, issue 1, page 25-30 ISSN 0105-6263 1365-2605 journal-article 2007 crwiley https://doi.org/10.1111/j.1365-2605.2007.00750.x 2024-06-06T04:22:52Z Summary In Greenland, with a male population of approximately 30 000 individuals, the incidence of prostate cancer is extremely low with only three cases described during the period 1988–1997. Polymorphisms related to high androgen metabolism and/or response in the 5 α ‐reductase type 2 (SRD5A2) and the androgen receptor (AR) genes, respectively, have been linked to prostate cancer. Our objective was to analyse whether the distribution of these polymorphisms differed between the prostate cancer low‐risk population from Greenland and the relatively high‐risk Swedish male population. The SRD5A2 polymorphisms A49T, V89L and R227Q, and the CAG and GGN repeats in the AR gene were genotyped in leucocyte DNA from 196 Greenlanders and 305 Swedish military conscripts. All subjects had the wild‐type R/R genotype of the R227Q marker. The high‐activity variants A49T A/T and V89L V/V occurred less frequently (2% vs. 5%, p = 0.048 and 33% vs. 46%, p = 0.0027) in Greenland compared with Sweden, whereas the low‐activity L/L genotype was more frequent in Greenland (24% vs. 13%, p = 0.0024). Greenlanders also had longer AR CAG repeats than the Swedish population (median 24 vs 22, p < 0.0005). Greenlanders also had a higher frequency of the GGN = 23 allele (85% vs. 54%, p < 0.0001). Our results suggest that Greenlanders are genetically predisposed to a lower activity in testosterone to 5 α ‐dihydrotestosterone turnover and to lower AR activity, which, at least partly, could explain their low incidence of prostate cancer. Article in Journal/Newspaper Greenland greenlander* inuit Wiley Online Library Greenland International Journal of Andrology 0 0 070322041217002 ??? |
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Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Summary In Greenland, with a male population of approximately 30 000 individuals, the incidence of prostate cancer is extremely low with only three cases described during the period 1988–1997. Polymorphisms related to high androgen metabolism and/or response in the 5 α ‐reductase type 2 (SRD5A2) and the androgen receptor (AR) genes, respectively, have been linked to prostate cancer. Our objective was to analyse whether the distribution of these polymorphisms differed between the prostate cancer low‐risk population from Greenland and the relatively high‐risk Swedish male population. The SRD5A2 polymorphisms A49T, V89L and R227Q, and the CAG and GGN repeats in the AR gene were genotyped in leucocyte DNA from 196 Greenlanders and 305 Swedish military conscripts. All subjects had the wild‐type R/R genotype of the R227Q marker. The high‐activity variants A49T A/T and V89L V/V occurred less frequently (2% vs. 5%, p = 0.048 and 33% vs. 46%, p = 0.0027) in Greenland compared with Sweden, whereas the low‐activity L/L genotype was more frequent in Greenland (24% vs. 13%, p = 0.0024). Greenlanders also had longer AR CAG repeats than the Swedish population (median 24 vs 22, p < 0.0005). Greenlanders also had a higher frequency of the GGN = 23 allele (85% vs. 54%, p < 0.0001). Our results suggest that Greenlanders are genetically predisposed to a lower activity in testosterone to 5 α ‐dihydrotestosterone turnover and to lower AR activity, which, at least partly, could explain their low incidence of prostate cancer. |
format |
Article in Journal/Newspaper |
author |
Giwercman, Charlotte Giwercman, Aleksander Pedersen, Henning Sloth Toft, Gunnar Lundin, Kristina Bonde, Jens‐Peter Giwercman, Yvonne Lundberg |
spellingShingle |
Giwercman, Charlotte Giwercman, Aleksander Pedersen, Henning Sloth Toft, Gunnar Lundin, Kristina Bonde, Jens‐Peter Giwercman, Yvonne Lundberg Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians |
author_facet |
Giwercman, Charlotte Giwercman, Aleksander Pedersen, Henning Sloth Toft, Gunnar Lundin, Kristina Bonde, Jens‐Peter Giwercman, Yvonne Lundberg |
author_sort |
Giwercman, Charlotte |
title |
Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians |
title_short |
Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians |
title_full |
Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians |
title_fullStr |
Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians |
title_full_unstemmed |
Polymorphisms in genes regulating androgen activity among prostate cancer low‐risk Inuit men and high‐risk Scandinavians |
title_sort |
polymorphisms in genes regulating androgen activity among prostate cancer low‐risk inuit men and high‐risk scandinavians |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1111/j.1365-2605.2007.00750.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2605.2007.00750.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2605.2007.00750.x |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlander* inuit |
genre_facet |
Greenland greenlander* inuit |
op_source |
International Journal of Andrology volume 31, issue 1, page 25-30 ISSN 0105-6263 1365-2605 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2605.2007.00750.x |
container_title |
International Journal of Andrology |
container_volume |
0 |
container_issue |
0 |
container_start_page |
070322041217002 |
op_container_end_page |
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1802644798039916544 |