Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study
Summary Testosterone levels decrease with age. The mechanisms responsible for the age‐related decrease in testosterone concentration are still being debated, and probably involve all three levels of the hypothalamo‐pituitary‐testicular axis. Luteinizing hormone (LH) concentration is often measured i...
Published in: | International Journal of Andrology |
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crwiley:10.1111/j.1365-2605.2006.00732.x 2024-06-02T08:15:19+00:00 Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study Svartberg, Johan Jorde, Rolf 2007 http://dx.doi.org/10.1111/j.1365-2605.2006.00732.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2605.2006.00732.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2605.2006.00732.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Andrology volume 30, issue 5, page 445-451 ISSN 0105-6263 1365-2605 journal-article 2007 crwiley https://doi.org/10.1111/j.1365-2605.2006.00732.x 2024-05-03T10:57:12Z Summary Testosterone levels decrease with age. The mechanisms responsible for the age‐related decrease in testosterone concentration are still being debated, and probably involve all three levels of the hypothalamo‐pituitary‐testicular axis. Luteinizing hormone (LH) concentration is often measured in combination with testosterone, but its value is questionable when considering the testosterone levels of older men. The objective of the present study was to examine the associations of endogenous gonadotropin and testosterone levels both in a cross‐sectional cohort of 3447 men participating in the fifth Tromsø study and longitudinally in a cohort of 1352 men participating in both the fourth and the fifth Tromsø study. Total testosterone, LH, follicle‐stimulating hormone and sex hormone‐binding globulin levels were measured with immunoassay while free testosterone levels were calculated. Total testosterone and LH were independently and positively associated in the cross‐sectional analyses ( p < 0.001). In the longitudinal study, however, LH levels did not predict changes in total and free testosterone levels. Thus, in clinical practice, measuring gonadotropins seems to be of limited value in detecting hypogonadism in ageing men. Article in Journal/Newspaper Tromsø Wiley Online Library Tromsø International Journal of Andrology 30 5 445 451 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Summary Testosterone levels decrease with age. The mechanisms responsible for the age‐related decrease in testosterone concentration are still being debated, and probably involve all three levels of the hypothalamo‐pituitary‐testicular axis. Luteinizing hormone (LH) concentration is often measured in combination with testosterone, but its value is questionable when considering the testosterone levels of older men. The objective of the present study was to examine the associations of endogenous gonadotropin and testosterone levels both in a cross‐sectional cohort of 3447 men participating in the fifth Tromsø study and longitudinally in a cohort of 1352 men participating in both the fourth and the fifth Tromsø study. Total testosterone, LH, follicle‐stimulating hormone and sex hormone‐binding globulin levels were measured with immunoassay while free testosterone levels were calculated. Total testosterone and LH were independently and positively associated in the cross‐sectional analyses ( p < 0.001). In the longitudinal study, however, LH levels did not predict changes in total and free testosterone levels. Thus, in clinical practice, measuring gonadotropins seems to be of limited value in detecting hypogonadism in ageing men. |
format |
Article in Journal/Newspaper |
author |
Svartberg, Johan Jorde, Rolf |
spellingShingle |
Svartberg, Johan Jorde, Rolf Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study |
author_facet |
Svartberg, Johan Jorde, Rolf |
author_sort |
Svartberg, Johan |
title |
Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study |
title_short |
Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study |
title_full |
Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study |
title_fullStr |
Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study |
title_full_unstemmed |
Measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the Tromsø study |
title_sort |
measuring gonadotropins is of limited value in detecting hypogonadism in ageing men: the tromsø study |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1111/j.1365-2605.2006.00732.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2605.2006.00732.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2605.2006.00732.x |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
International Journal of Andrology volume 30, issue 5, page 445-451 ISSN 0105-6263 1365-2605 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2605.2006.00732.x |
container_title |
International Journal of Andrology |
container_volume |
30 |
container_issue |
5 |
container_start_page |
445 |
op_container_end_page |
451 |
_version_ |
1800739447705174016 |