Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations
Summary Allelic frequencies at the three most polymorphic loci of the HLA class II region (DRB1, DQA1 and DQB1) were determined in the Nganasan and Ket, the remnants of the two most ancient groups in the Lower Yenisey River/Taimyr Peninsula region in northern Siberia. By single‐stranded conformation...
Published in: | European Journal of Immunogenetics |
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crwiley:10.1111/j.1365-2370.2004.00443.x 2024-09-15T18:20:23+00:00 Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations Uinuk‐ool, T. S. Takezaki, N. Derbeneva, O. A. Volodko, N. V. Sukernik, R. I. 2004 http://dx.doi.org/10.1111/j.1365-2370.2004.00443.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2370.2004.00443.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2370.2004.00443.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Immunogenetics volume 31, issue 1, page 43-51 ISSN 0960-7420 1365-2370 journal-article 2004 crwiley https://doi.org/10.1111/j.1365-2370.2004.00443.x 2024-09-05T05:07:15Z Summary Allelic frequencies at the three most polymorphic loci of the HLA class II region (DRB1, DQA1 and DQB1) were determined in the Nganasan and Ket, the remnants of the two most ancient groups in the Lower Yenisey River/Taimyr Peninsula region in northern Siberia. By single‐stranded conformational polymorphism typing, verified by sequencing, 19 HLA‐DRB1‐DQA1‐DQB1 haplotypes and 15 HLA‐DRB1, seven DQA1 and 11 DQB1 alleles were found. The most frequent alleles were DRB1*1301 (23.5%), DQA1*0103 (29.4%), *0501/03/05 (29.4%), and DQB1*0301/09 (32.4%) in the Ket, and DRB1*0901 (25%), DQA1*0301 (39.6%), and DQB1*0301/09 (37.5%) in the Nganasan. The distribution patterns and comprehensive phylogenic analysis based on the haplotype frequencies of 17 Siberian populations suggest that the founders of both the Ket and the Nganasan came from Palaeolithic populations in the Altai‐Sayan Upland. Article in Journal/Newspaper Nganasan* Taimyr yenisey river Siberia Wiley Online Library European Journal of Immunogenetics 31 1 43 51 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Summary Allelic frequencies at the three most polymorphic loci of the HLA class II region (DRB1, DQA1 and DQB1) were determined in the Nganasan and Ket, the remnants of the two most ancient groups in the Lower Yenisey River/Taimyr Peninsula region in northern Siberia. By single‐stranded conformational polymorphism typing, verified by sequencing, 19 HLA‐DRB1‐DQA1‐DQB1 haplotypes and 15 HLA‐DRB1, seven DQA1 and 11 DQB1 alleles were found. The most frequent alleles were DRB1*1301 (23.5%), DQA1*0103 (29.4%), *0501/03/05 (29.4%), and DQB1*0301/09 (32.4%) in the Ket, and DRB1*0901 (25%), DQA1*0301 (39.6%), and DQB1*0301/09 (37.5%) in the Nganasan. The distribution patterns and comprehensive phylogenic analysis based on the haplotype frequencies of 17 Siberian populations suggest that the founders of both the Ket and the Nganasan came from Palaeolithic populations in the Altai‐Sayan Upland. |
format |
Article in Journal/Newspaper |
author |
Uinuk‐ool, T. S. Takezaki, N. Derbeneva, O. A. Volodko, N. V. Sukernik, R. I. |
spellingShingle |
Uinuk‐ool, T. S. Takezaki, N. Derbeneva, O. A. Volodko, N. V. Sukernik, R. I. Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations |
author_facet |
Uinuk‐ool, T. S. Takezaki, N. Derbeneva, O. A. Volodko, N. V. Sukernik, R. I. |
author_sort |
Uinuk‐ool, T. S. |
title |
Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations |
title_short |
Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations |
title_full |
Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations |
title_fullStr |
Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations |
title_full_unstemmed |
Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations |
title_sort |
variation of hla class ii genes in the nganasan and ket, two aboriginal siberian populations |
publisher |
Wiley |
publishDate |
2004 |
url |
http://dx.doi.org/10.1111/j.1365-2370.2004.00443.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2370.2004.00443.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2370.2004.00443.x |
genre |
Nganasan* Taimyr yenisey river Siberia |
genre_facet |
Nganasan* Taimyr yenisey river Siberia |
op_source |
European Journal of Immunogenetics volume 31, issue 1, page 43-51 ISSN 0960-7420 1365-2370 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2370.2004.00443.x |
container_title |
European Journal of Immunogenetics |
container_volume |
31 |
container_issue |
1 |
container_start_page |
43 |
op_container_end_page |
51 |
_version_ |
1810458779340242944 |