Sparteine oxidation polymorphism in Greenlanders living in Denmark.
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2‐ + 5‐dehydrosparteine in a 12 h urine sample r...
Published in: | British Journal of Clinical Pharmacology |
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Online Access: | http://dx.doi.org/10.1111/j.1365-2125.1986.tb02911.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2125.1986.tb02911.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1986.tb02911.x |
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crwiley:10.1111/j.1365-2125.1986.tb02911.x 2024-09-30T14:36:02+00:00 Sparteine oxidation polymorphism in Greenlanders living in Denmark. Brosen, K 1986 http://dx.doi.org/10.1111/j.1365-2125.1986.tb02911.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2125.1986.tb02911.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1986.tb02911.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor British Journal of Clinical Pharmacology volume 22, issue 4, page 415-419 ISSN 0306-5251 1365-2125 journal-article 1986 crwiley https://doi.org/10.1111/j.1365-2125.1986.tb02911.x 2024-09-17T04:48:22Z Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2‐ + 5‐dehydrosparteine in a 12 h urine sample ranged from 0.06‐3.12 in EM and from 30‐480 in PM. The excretion of dehydrosparteines accounted for less than 2.2% of the dose in PM and ranged from 5.6%‐63% in EM. The urinary recovery (% of dose) of sparteine, 2‐dehydrosparteine and total sparteine + dehydrosparteines was lower in Greenlander EM than in Danish EM (Brosen et al., 1985). Incomplete urine collection in a substantial proportion of the Greenlanders could explain these discrepancies. Article in Journal/Newspaper greenlander* Wiley Online Library British Journal of Clinical Pharmacology 22 4 415 419 |
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Wiley Online Library |
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English |
description |
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2‐ + 5‐dehydrosparteine in a 12 h urine sample ranged from 0.06‐3.12 in EM and from 30‐480 in PM. The excretion of dehydrosparteines accounted for less than 2.2% of the dose in PM and ranged from 5.6%‐63% in EM. The urinary recovery (% of dose) of sparteine, 2‐dehydrosparteine and total sparteine + dehydrosparteines was lower in Greenlander EM than in Danish EM (Brosen et al., 1985). Incomplete urine collection in a substantial proportion of the Greenlanders could explain these discrepancies. |
format |
Article in Journal/Newspaper |
author |
Brosen, K |
spellingShingle |
Brosen, K Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
author_facet |
Brosen, K |
author_sort |
Brosen, K |
title |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_short |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_full |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_fullStr |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_full_unstemmed |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_sort |
sparteine oxidation polymorphism in greenlanders living in denmark. |
publisher |
Wiley |
publishDate |
1986 |
url |
http://dx.doi.org/10.1111/j.1365-2125.1986.tb02911.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2125.1986.tb02911.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1986.tb02911.x |
genre |
greenlander* |
genre_facet |
greenlander* |
op_source |
British Journal of Clinical Pharmacology volume 22, issue 4, page 415-419 ISSN 0306-5251 1365-2125 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2125.1986.tb02911.x |
container_title |
British Journal of Clinical Pharmacology |
container_volume |
22 |
container_issue |
4 |
container_start_page |
415 |
op_container_end_page |
419 |
_version_ |
1811639208403533824 |