Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus)
Summary Disease resistance‐related traits have received increasing importance in aquaculture breeding programs worldwide. Currently, genomic information offers new possibilities in breeding to address the improvement of this kind of traits. The turbot is one of the most promising European aquacultur...
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crwiley:10.1111/j.1365-2052.2012.02385.x 2024-06-23T07:56:37+00:00 Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) Rodríguez‐Ramilo, S. T. Fernández, J. Toro, M. A. Bouza, C. Hermida, M. Fernández, C. Pardo, B. G. Cabaleiro, S. Martínez, P. 2012 http://dx.doi.org/10.1111/j.1365-2052.2012.02385.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2052.2012.02385.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2052.2012.02385.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Animal Genetics volume 44, issue 2, page 149-157 ISSN 0268-9146 1365-2052 journal-article 2012 crwiley https://doi.org/10.1111/j.1365-2052.2012.02385.x 2024-06-13T04:22:08Z Summary Disease resistance‐related traits have received increasing importance in aquaculture breeding programs worldwide. Currently, genomic information offers new possibilities in breeding to address the improvement of this kind of traits. The turbot is one of the most promising European aquaculture species, and P hilasterides dicentrarchi is a scuticociliate parasite causing fatal disease in farmed turbot. An appealing approach to fight against disease is to achieve a more robust broodstock, which could prevent or diminish the devastating effects of scuticociliatosis on farmed individuals. In the present study, a genome scan for quantitative trait loci ( QTL ) affecting resistance and survival time to P . dicentrarchi in four turbot families was carried out. The objectives were to identify QTL using different statistical approaches [linear regression ( LR ) and maximum likelihood ( ML )] and to locate significantly associated markers for their application in genetic breeding strategies. Several genomic regions controlling resistance and survival time to P . dicentrarchi were detected. When analyzing each family separately, significant QTL for resistance were identified by the LR method in two linkage groups ( LG 1 and LG 9) and for survival time in LG 1, while the ML methodology identified QTL for resistance in LG 9 and LG 23 and for survival time in LG 6 and LG 23. The analysis of the total data set identified an additional significant QTL for resistance and survival time in LG 3 with the LR method. Significant association between disease resistance‐related traits and genotypes was detected for several markers, a single one explaining up to 22% of the phenotypic variance. Obtained results will be essential to identify candidate genes for resistance and to apply them in marker‐assisted selection programs to improve turbot production. Article in Journal/Newspaper Scophthalmus maximus Turbot Wiley Online Library Animal Genetics 44 2 149 157 |
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Wiley Online Library |
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English |
description |
Summary Disease resistance‐related traits have received increasing importance in aquaculture breeding programs worldwide. Currently, genomic information offers new possibilities in breeding to address the improvement of this kind of traits. The turbot is one of the most promising European aquaculture species, and P hilasterides dicentrarchi is a scuticociliate parasite causing fatal disease in farmed turbot. An appealing approach to fight against disease is to achieve a more robust broodstock, which could prevent or diminish the devastating effects of scuticociliatosis on farmed individuals. In the present study, a genome scan for quantitative trait loci ( QTL ) affecting resistance and survival time to P . dicentrarchi in four turbot families was carried out. The objectives were to identify QTL using different statistical approaches [linear regression ( LR ) and maximum likelihood ( ML )] and to locate significantly associated markers for their application in genetic breeding strategies. Several genomic regions controlling resistance and survival time to P . dicentrarchi were detected. When analyzing each family separately, significant QTL for resistance were identified by the LR method in two linkage groups ( LG 1 and LG 9) and for survival time in LG 1, while the ML methodology identified QTL for resistance in LG 9 and LG 23 and for survival time in LG 6 and LG 23. The analysis of the total data set identified an additional significant QTL for resistance and survival time in LG 3 with the LR method. Significant association between disease resistance‐related traits and genotypes was detected for several markers, a single one explaining up to 22% of the phenotypic variance. Obtained results will be essential to identify candidate genes for resistance and to apply them in marker‐assisted selection programs to improve turbot production. |
format |
Article in Journal/Newspaper |
author |
Rodríguez‐Ramilo, S. T. Fernández, J. Toro, M. A. Bouza, C. Hermida, M. Fernández, C. Pardo, B. G. Cabaleiro, S. Martínez, P. |
spellingShingle |
Rodríguez‐Ramilo, S. T. Fernández, J. Toro, M. A. Bouza, C. Hermida, M. Fernández, C. Pardo, B. G. Cabaleiro, S. Martínez, P. Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) |
author_facet |
Rodríguez‐Ramilo, S. T. Fernández, J. Toro, M. A. Bouza, C. Hermida, M. Fernández, C. Pardo, B. G. Cabaleiro, S. Martínez, P. |
author_sort |
Rodríguez‐Ramilo, S. T. |
title |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) |
title_short |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) |
title_full |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) |
title_fullStr |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) |
title_full_unstemmed |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot ( Scophthalmus maximus) |
title_sort |
uncovering qtl for resistance and survival time to philasterides dicentrarchi in turbot ( scophthalmus maximus) |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1111/j.1365-2052.2012.02385.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2052.2012.02385.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2052.2012.02385.x |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Animal Genetics volume 44, issue 2, page 149-157 ISSN 0268-9146 1365-2052 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1365-2052.2012.02385.x |
container_title |
Animal Genetics |
container_volume |
44 |
container_issue |
2 |
container_start_page |
149 |
op_container_end_page |
157 |
_version_ |
1802649878460891136 |