Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder
Baltic salmon Salmo salar females displaying wiggling behaviour had significantly lower (P<0.05) hepatic and ovarian thiamine (vitamin B 1 ) concentrations than the normal females, confirming that they suffered from a thiamine deficiency. A significantly (P<0.05) increased monoaminergic activi...
Published in: | Journal of Fish Biology |
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crwiley:10.1111/j.1095-8649.2002.tb02435.x 2024-06-02T08:14:00+00:00 Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder Amcoff, P. Elofsson, U. O. E. Börjeson, H. Norrgren, L. Nilsson, G. E. 2002 http://dx.doi.org/10.1111/j.1095-8649.2002.tb02435.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1095-8649.2002.tb02435.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1095-8649.2002.tb02435.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Fish Biology volume 60, issue 6, page 1407-1416 ISSN 0022-1112 1095-8649 journal-article 2002 crwiley https://doi.org/10.1111/j.1095-8649.2002.tb02435.x 2024-05-03T11:40:00Z Baltic salmon Salmo salar females displaying wiggling behaviour had significantly lower (P<0.05) hepatic and ovarian thiamine (vitamin B 1 ) concentrations than the normal females, confirming that they suffered from a thiamine deficiency. A significantly (P<0.05) increased monoaminergic activity was found in the telencephalon and the hypothalamus of the wiggling individuals as indicated by [5‐hydroxyindoleacetic acid (5‐HIAA)]: [5‐hydroxytryptamine (5‐HT)] and [3,4‐dihydroxyphenylacetic acid (DOPAC)]: [dopamine (DA)] ratios. The 5‐HIAA concentrations of wiggling individuals were significantly (P<0.05) higher in the telencephalon and the hypothalamus compared to normal fish. Wiggling fish showed significantly (P<0.05) higher concentrations of the DA metabolite DOPAC in the hypothalamus and the brain stem compared to normal fish. Furthermore, the brain stem in wiggling fish contained significantly (P<0.05) less 5‐HT than in normal individuals, which was also reflected in a significant (P<0.05) increase in the (5‐HIAA): (5‐HT) ratio. These results demonstrate an increased serotonergic and dopaminergic activity in wiggling compared to normal fish. The altered monoaminergic activity may be directly related to altered brain thiamine metabolism, but a general stress caused by thiamine deficiency and an inability to regulate swim bladder inflation may contribute. Furthermore, a changed brain monoaminergic activity may contribute to the behaviour characterizing wiggling fish. Article in Journal/Newspaper Salmo salar Wiley Online Library Journal of Fish Biology 60 6 1407 1416 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Baltic salmon Salmo salar females displaying wiggling behaviour had significantly lower (P<0.05) hepatic and ovarian thiamine (vitamin B 1 ) concentrations than the normal females, confirming that they suffered from a thiamine deficiency. A significantly (P<0.05) increased monoaminergic activity was found in the telencephalon and the hypothalamus of the wiggling individuals as indicated by [5‐hydroxyindoleacetic acid (5‐HIAA)]: [5‐hydroxytryptamine (5‐HT)] and [3,4‐dihydroxyphenylacetic acid (DOPAC)]: [dopamine (DA)] ratios. The 5‐HIAA concentrations of wiggling individuals were significantly (P<0.05) higher in the telencephalon and the hypothalamus compared to normal fish. Wiggling fish showed significantly (P<0.05) higher concentrations of the DA metabolite DOPAC in the hypothalamus and the brain stem compared to normal fish. Furthermore, the brain stem in wiggling fish contained significantly (P<0.05) less 5‐HT than in normal individuals, which was also reflected in a significant (P<0.05) increase in the (5‐HIAA): (5‐HT) ratio. These results demonstrate an increased serotonergic and dopaminergic activity in wiggling compared to normal fish. The altered monoaminergic activity may be directly related to altered brain thiamine metabolism, but a general stress caused by thiamine deficiency and an inability to regulate swim bladder inflation may contribute. Furthermore, a changed brain monoaminergic activity may contribute to the behaviour characterizing wiggling fish. |
format |
Article in Journal/Newspaper |
author |
Amcoff, P. Elofsson, U. O. E. Börjeson, H. Norrgren, L. Nilsson, G. E. |
spellingShingle |
Amcoff, P. Elofsson, U. O. E. Börjeson, H. Norrgren, L. Nilsson, G. E. Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder |
author_facet |
Amcoff, P. Elofsson, U. O. E. Börjeson, H. Norrgren, L. Nilsson, G. E. |
author_sort |
Amcoff, P. |
title |
Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder |
title_short |
Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder |
title_full |
Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder |
title_fullStr |
Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder |
title_full_unstemmed |
Alterations of dopaminergic and serotonergic activity in the brain of sea‐run Baltic salmon suffering a thiamine deficiency‐related disorder |
title_sort |
alterations of dopaminergic and serotonergic activity in the brain of sea‐run baltic salmon suffering a thiamine deficiency‐related disorder |
publisher |
Wiley |
publishDate |
2002 |
url |
http://dx.doi.org/10.1111/j.1095-8649.2002.tb02435.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1095-8649.2002.tb02435.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1095-8649.2002.tb02435.x |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_source |
Journal of Fish Biology volume 60, issue 6, page 1407-1416 ISSN 0022-1112 1095-8649 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1095-8649.2002.tb02435.x |
container_title |
Journal of Fish Biology |
container_volume |
60 |
container_issue |
6 |
container_start_page |
1407 |
op_container_end_page |
1416 |
_version_ |
1800737685885681664 |