The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission
ABSTRACT Background and Aims. We have previously reported that Wasagamack, a Canadian First Nations community has a seroprevalence rate of Helicobacter pylori of 95% and a prevalence rate among children aged 0–12 years as measured by stool antigen testing of 56%. We aimed to determine the rate of in...
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crwiley:10.1111/j.1083-4389.2004.00199.x 2024-06-02T08:06:42+00:00 The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission Sinha, Samir K. Martin, Bruce Gold, Benjamin D. Song, Qunsheng Sargent, Michael Bernstein, Charles N. 2004 http://dx.doi.org/10.1111/j.1083-4389.2004.00199.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1083-4389.2004.00199.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1083-4389.2004.00199.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Helicobacter volume 9, issue 1, page 59-68 ISSN 1083-4389 1523-5378 journal-article 2004 crwiley https://doi.org/10.1111/j.1083-4389.2004.00199.x 2024-05-03T11:28:27Z ABSTRACT Background and Aims. We have previously reported that Wasagamack, a Canadian First Nations community has a seroprevalence rate of Helicobacter pylori of 95% and a prevalence rate among children aged 0–12 years as measured by stool antigen testing of 56%. We aimed to determine the rate of infection acquisition and possible modes of transmission of childhood Helicobacter pylori infection in this Canadian First Nations community. Methods. Children who were previously negative for H. pylori by stool antigen testing in August 1999 were eligible for enrollment in August 2000; 50 (77%) eligible children underwent stool collection. H. pylori stool antigen status was tested using the Premier Platinum HpSA test. Drinking water samples, maternal saliva, breast milk, local berries and flies were tested by three complementary H. pylori ‐specific PCR assays. Soothers or bottle nipples, collected from 16 children whose H. pylori stool antigen status was determined, were bathed in sterile water and this water was tested by PCR. Results. Stool was positive for H. pylori in 16% (8/50) of children retested. Five had no other siblings infected and three had infected siblings. The mothers of all children infected were positive for H. pylori . The median age of newly infected children was 6 years (range 1–13 years). By PCR, 78% (18/23) mothers’ saliva samples, 69% (11/16) soother water samples and 9% (1/11) water samples from infected homes tested positive. All of 24 sequenced PCR‐produced DNA fragments from samples showed 99% homology with that from ATCC type strain H. pylori . Conclusions. The rate of childhood H. pylori acquisition was 16% over 1 year, and was not dependent on number of siblings infected. The finding of homologous H. pylori DNA in saliva and in soother water suggests the possibility of human to human transmission, particularly via an oral–oral route. Thus, there is the potential for further investigations in this population and other endemic communities that are directed at prevention of infection ... Article in Journal/Newspaper First Nations Wiley Online Library Helicobacter 9 1 59 68 |
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Wiley Online Library |
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English |
description |
ABSTRACT Background and Aims. We have previously reported that Wasagamack, a Canadian First Nations community has a seroprevalence rate of Helicobacter pylori of 95% and a prevalence rate among children aged 0–12 years as measured by stool antigen testing of 56%. We aimed to determine the rate of infection acquisition and possible modes of transmission of childhood Helicobacter pylori infection in this Canadian First Nations community. Methods. Children who were previously negative for H. pylori by stool antigen testing in August 1999 were eligible for enrollment in August 2000; 50 (77%) eligible children underwent stool collection. H. pylori stool antigen status was tested using the Premier Platinum HpSA test. Drinking water samples, maternal saliva, breast milk, local berries and flies were tested by three complementary H. pylori ‐specific PCR assays. Soothers or bottle nipples, collected from 16 children whose H. pylori stool antigen status was determined, were bathed in sterile water and this water was tested by PCR. Results. Stool was positive for H. pylori in 16% (8/50) of children retested. Five had no other siblings infected and three had infected siblings. The mothers of all children infected were positive for H. pylori . The median age of newly infected children was 6 years (range 1–13 years). By PCR, 78% (18/23) mothers’ saliva samples, 69% (11/16) soother water samples and 9% (1/11) water samples from infected homes tested positive. All of 24 sequenced PCR‐produced DNA fragments from samples showed 99% homology with that from ATCC type strain H. pylori . Conclusions. The rate of childhood H. pylori acquisition was 16% over 1 year, and was not dependent on number of siblings infected. The finding of homologous H. pylori DNA in saliva and in soother water suggests the possibility of human to human transmission, particularly via an oral–oral route. Thus, there is the potential for further investigations in this population and other endemic communities that are directed at prevention of infection ... |
format |
Article in Journal/Newspaper |
author |
Sinha, Samir K. Martin, Bruce Gold, Benjamin D. Song, Qunsheng Sargent, Michael Bernstein, Charles N. |
spellingShingle |
Sinha, Samir K. Martin, Bruce Gold, Benjamin D. Song, Qunsheng Sargent, Michael Bernstein, Charles N. The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission |
author_facet |
Sinha, Samir K. Martin, Bruce Gold, Benjamin D. Song, Qunsheng Sargent, Michael Bernstein, Charles N. |
author_sort |
Sinha, Samir K. |
title |
The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission |
title_short |
The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission |
title_full |
The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission |
title_fullStr |
The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission |
title_full_unstemmed |
The Incidence of Helicobacter pylori Acquisition in Children of a Canadian First Nations Community and the Potential for Parent‐to‐Child Transmission |
title_sort |
incidence of helicobacter pylori acquisition in children of a canadian first nations community and the potential for parent‐to‐child transmission |
publisher |
Wiley |
publishDate |
2004 |
url |
http://dx.doi.org/10.1111/j.1083-4389.2004.00199.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1083-4389.2004.00199.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1083-4389.2004.00199.x |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Helicobacter volume 9, issue 1, page 59-68 ISSN 1083-4389 1523-5378 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.1083-4389.2004.00199.x |
container_title |
Helicobacter |
container_volume |
9 |
container_issue |
1 |
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59 |
op_container_end_page |
68 |
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