Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex
ABSTRACT A family study of serum high density lipoprotein (HDL) cholesterol and total serum cholesterol concentration has been undertaken, and the relation to age, sex, cigarette smoking, physical activity and familial occurrence of myocardial infarction (MI) was examined. HDL cholesterol was determ...
Published in: | Acta Medica Scandinavica |
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Language: | English |
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Wiley
1977
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Online Access: | http://dx.doi.org/10.1111/j.0954-6820.1977.tb15707.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.0954-6820.1977.tb15707.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.0954-6820.1977.tb15707.x |
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crwiley:10.1111/j.0954-6820.1977.tb15707.x 2024-09-09T20:12:05+00:00 Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex The Tromsø Heart Study Mjøs, O. D. Thelle, D. S. Førde, O. H. Vik‐Mo, H. 1977 http://dx.doi.org/10.1111/j.0954-6820.1977.tb15707.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.0954-6820.1977.tb15707.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.0954-6820.1977.tb15707.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Medica Scandinavica volume 201, issue 1-6, page 323-329 ISSN 0001-6101 journal-article 1977 crwiley https://doi.org/10.1111/j.0954-6820.1977.tb15707.x 2024-06-20T04:22:51Z ABSTRACT A family study of serum high density lipoprotein (HDL) cholesterol and total serum cholesterol concentration has been undertaken, and the relation to age, sex, cigarette smoking, physical activity and familial occurrence of myocardial infarction (MI) was examined. HDL cholesterol was determined in 251 females and 194 males and total serum cholesterol in 677 females and 657 males, all aged 0–49 years. With respect to HDL cholesterol, significant sex differences were observed both in absolute level and in age‐related change. A negative correlation between HDL cholesterol and total serum cholesterol was observed in all age groups except females aged 0–19 years, supporting the hypothesis of HDL as a “clearing” lipoprotein. HDL cholesterol showed a positive correlation only in pairs of first‐degree relatives involving the mother and in sib‐sib pairs of the same sex. On the other hand, for serum cholesterol a positive correlation was found among all family members, although significantly higher between first‐degree relatives than between spouses. No relation was found between cigarette smoking, physical activity or familial occurrence of MI and the HDL cholesterol or total serum cholesterol concentrations. In accordance with the “HDL hypothesis”, the present finding could partly explain the higher incidence of ischaemic heart disease (IHD) in males than in females, and partly also the high risk which is transmitted from women with IHD to their first‐degree relatives. Article in Journal/Newspaper Tromsø Wiley Online Library Tromsø Acta Medica Scandinavica 201 1-6 323 329 |
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Wiley Online Library |
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crwiley |
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English |
description |
ABSTRACT A family study of serum high density lipoprotein (HDL) cholesterol and total serum cholesterol concentration has been undertaken, and the relation to age, sex, cigarette smoking, physical activity and familial occurrence of myocardial infarction (MI) was examined. HDL cholesterol was determined in 251 females and 194 males and total serum cholesterol in 677 females and 657 males, all aged 0–49 years. With respect to HDL cholesterol, significant sex differences were observed both in absolute level and in age‐related change. A negative correlation between HDL cholesterol and total serum cholesterol was observed in all age groups except females aged 0–19 years, supporting the hypothesis of HDL as a “clearing” lipoprotein. HDL cholesterol showed a positive correlation only in pairs of first‐degree relatives involving the mother and in sib‐sib pairs of the same sex. On the other hand, for serum cholesterol a positive correlation was found among all family members, although significantly higher between first‐degree relatives than between spouses. No relation was found between cigarette smoking, physical activity or familial occurrence of MI and the HDL cholesterol or total serum cholesterol concentrations. In accordance with the “HDL hypothesis”, the present finding could partly explain the higher incidence of ischaemic heart disease (IHD) in males than in females, and partly also the high risk which is transmitted from women with IHD to their first‐degree relatives. |
format |
Article in Journal/Newspaper |
author |
Mjøs, O. D. Thelle, D. S. Førde, O. H. Vik‐Mo, H. |
spellingShingle |
Mjøs, O. D. Thelle, D. S. Førde, O. H. Vik‐Mo, H. Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex |
author_facet |
Mjøs, O. D. Thelle, D. S. Førde, O. H. Vik‐Mo, H. |
author_sort |
Mjøs, O. D. |
title |
Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex |
title_short |
Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex |
title_full |
Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex |
title_fullStr |
Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex |
title_full_unstemmed |
Family Study of High Density Lipoprotein Cholesterol and the Relation to Age and Sex |
title_sort |
family study of high density lipoprotein cholesterol and the relation to age and sex |
publisher |
Wiley |
publishDate |
1977 |
url |
http://dx.doi.org/10.1111/j.0954-6820.1977.tb15707.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.0954-6820.1977.tb15707.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.0954-6820.1977.tb15707.x |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Acta Medica Scandinavica volume 201, issue 1-6, page 323-329 ISSN 0001-6101 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/j.0954-6820.1977.tb15707.x |
container_title |
Acta Medica Scandinavica |
container_volume |
201 |
container_issue |
1-6 |
container_start_page |
323 |
op_container_end_page |
329 |
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1809946681016320000 |