Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities
Abstract Background The high prevalence of Helicobacter pylori ( H. pylori ) infection in eastern Siberia is consistently established. In the same geographic area, however, fragmentary information is available on the epidemiology of the peptic ulcer disease ( PUD ). Aim To assess the prevalence of H...
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crwiley:10.1111/hel.12322 2024-06-02T08:06:17+00:00 Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities Tsukanov, Vladislav V. Kasparov, Edward V. Tonkikh, Julia L. Shtygasheva, Olga V. Butorin, Nikolay N. Amelchugova, Olga S. Vasyutin, Alexander V. Bronnikova, Elena P. Fassan, Matteo Rugge, Massimo Associazione Italiana per la Ricerca sul Cancro 2016 http://dx.doi.org/10.1111/hel.12322 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhel.12322 https://onlinelibrary.wiley.com/doi/pdf/10.1111/hel.12322 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Helicobacter volume 22, issue 1 ISSN 1083-4389 1523-5378 journal-article 2016 crwiley https://doi.org/10.1111/hel.12322 2024-05-03T12:03:52Z Abstract Background The high prevalence of Helicobacter pylori ( H. pylori ) infection in eastern Siberia is consistently established. In the same geographic area, however, fragmentary information is available on the epidemiology of the peptic ulcer disease ( PUD ). Aim To assess the prevalence of H. pylori infection (including CagA status ) and PUD in different eastern Siberian ethnicities. Patients and Methods An endoscopy population of 3149 eastern Siberian dyspeptic patients was considered [1727 Europoids and 1422 Mongoloids (Evenks = 792; Khakases = 630)]. H. pylori status was assessed by urease test and/or serum anti‐ H. pylori IgG and/or histology. CagA status was serologically assessed (anti‐CagA antibodies). Results All the Siberian ethnicities featured high rates of H. pylori infection (Europoids = 87.1%, Evenks = 88.6%, Khakases = 85.4%). Among the 1504 H. pylori ‐positive Europoids, the prevalence of CagA‐positive status (68.7%) was significantly higher than that featured by the 1240 H. pylori ‐positive Mongoloid ethnicities (46.9%; p < .001 for both comparisons). Peptic ulcer disease significantly prevailed among Europoids (prevalence among Europoid Evenks and Khakases: 8.9% and 8.3%, respectively; prevalence among Mongoloid Evenks and Khakases = 1.0% and 4.4%, respectively). Conclusions eastern Siberian populations feature consistent high rates of H. pylori infection, but different prevalence of peptic ulcer disease. In particular, Europoids featured a prevalence of both CagA‐positive status and peptic ulcer disease significantly higher than that of the Mongoloid ethnicities. These results suggest that both environmental factors (coexisting with the H. pylori infection) and host‐related variables modulate the clinicopathological expression of the H. pylori ‐associated gastric diseases. Article in Journal/Newspaper Evenks Siberia Wiley Online Library Helicobacter 22 1 |
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Wiley Online Library |
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English |
description |
Abstract Background The high prevalence of Helicobacter pylori ( H. pylori ) infection in eastern Siberia is consistently established. In the same geographic area, however, fragmentary information is available on the epidemiology of the peptic ulcer disease ( PUD ). Aim To assess the prevalence of H. pylori infection (including CagA status ) and PUD in different eastern Siberian ethnicities. Patients and Methods An endoscopy population of 3149 eastern Siberian dyspeptic patients was considered [1727 Europoids and 1422 Mongoloids (Evenks = 792; Khakases = 630)]. H. pylori status was assessed by urease test and/or serum anti‐ H. pylori IgG and/or histology. CagA status was serologically assessed (anti‐CagA antibodies). Results All the Siberian ethnicities featured high rates of H. pylori infection (Europoids = 87.1%, Evenks = 88.6%, Khakases = 85.4%). Among the 1504 H. pylori ‐positive Europoids, the prevalence of CagA‐positive status (68.7%) was significantly higher than that featured by the 1240 H. pylori ‐positive Mongoloid ethnicities (46.9%; p < .001 for both comparisons). Peptic ulcer disease significantly prevailed among Europoids (prevalence among Europoid Evenks and Khakases: 8.9% and 8.3%, respectively; prevalence among Mongoloid Evenks and Khakases = 1.0% and 4.4%, respectively). Conclusions eastern Siberian populations feature consistent high rates of H. pylori infection, but different prevalence of peptic ulcer disease. In particular, Europoids featured a prevalence of both CagA‐positive status and peptic ulcer disease significantly higher than that of the Mongoloid ethnicities. These results suggest that both environmental factors (coexisting with the H. pylori infection) and host‐related variables modulate the clinicopathological expression of the H. pylori ‐associated gastric diseases. |
author2 |
Associazione Italiana per la Ricerca sul Cancro |
format |
Article in Journal/Newspaper |
author |
Tsukanov, Vladislav V. Kasparov, Edward V. Tonkikh, Julia L. Shtygasheva, Olga V. Butorin, Nikolay N. Amelchugova, Olga S. Vasyutin, Alexander V. Bronnikova, Elena P. Fassan, Matteo Rugge, Massimo |
spellingShingle |
Tsukanov, Vladislav V. Kasparov, Edward V. Tonkikh, Julia L. Shtygasheva, Olga V. Butorin, Nikolay N. Amelchugova, Olga S. Vasyutin, Alexander V. Bronnikova, Elena P. Fassan, Matteo Rugge, Massimo Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities |
author_facet |
Tsukanov, Vladislav V. Kasparov, Edward V. Tonkikh, Julia L. Shtygasheva, Olga V. Butorin, Nikolay N. Amelchugova, Olga S. Vasyutin, Alexander V. Bronnikova, Elena P. Fassan, Matteo Rugge, Massimo |
author_sort |
Tsukanov, Vladislav V. |
title |
Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities |
title_short |
Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities |
title_full |
Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities |
title_fullStr |
Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities |
title_full_unstemmed |
Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities |
title_sort |
peptic ulcer disease and helicobacter pylori infection in different siberian ethnicities |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/hel.12322 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhel.12322 https://onlinelibrary.wiley.com/doi/pdf/10.1111/hel.12322 |
genre |
Evenks Siberia |
genre_facet |
Evenks Siberia |
op_source |
Helicobacter volume 22, issue 1 ISSN 1083-4389 1523-5378 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/hel.12322 |
container_title |
Helicobacter |
container_volume |
22 |
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1 |
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1800751204621352960 |