Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming
Abstract Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high‐resolution mass‐spectrometry‐based lipidomics can provide insights into adap...
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Online Access: | http://dx.doi.org/10.1111/gcb.15638 https://onlinelibrary.wiley.com/doi/pdf/10.1111/gcb.15638 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/gcb.15638 |
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crwiley:10.1111/gcb.15638 2024-06-02T08:00:20+00:00 Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming Wang, Chao Gong, Yufeng Deng, Fuchang Ding, Enmin Tang, Jie Codling, Garry Challis, Jonathan K. Green, Derek Wang, Jing Chen, Qiliang Xie, Yuwei Su, Shu Yang, Zilin Raine, Jason Jones, Paul D. Tang, Song Giesy, John P. Canada First Research Excellence Fund Natural Sciences and Engineering Research Council of Canada 2021 http://dx.doi.org/10.1111/gcb.15638 https://onlinelibrary.wiley.com/doi/pdf/10.1111/gcb.15638 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/gcb.15638 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Global Change Biology volume 27, issue 14, page 3282-3298 ISSN 1354-1013 1365-2486 journal-article 2021 crwiley https://doi.org/10.1111/gcb.15638 2024-05-03T10:39:24Z Abstract Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high‐resolution mass‐spectrometry‐based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species—Arctic char ( Salvelinus alpinus )—with a detailed multi‐tissue analysis of the lipidome in response to chronic shifts in temperature using a validated lipidomics workflow. In addition, dynamic alterations in the hepatic lipidome during the time course of shifts in temperature were also characterized. Our results showed that early life stages of Arctic char were more susceptible to variations in temperature. One‐year‐old Arctic char responded to chronic increases in temperature with coordinated regulation of lipids, including headgroup‐specific remodeling of acyl chains in glycerophospholipids (GP) and extensive alterations in composition of lipids in membranes, such as less lyso‐GPs, and more ether‐GPs and sphingomyelin. Glycerolipids (e.g., triacylglycerol, TG) also participated in adaptive responses of the lipidome of Arctic char. Eight‐week‐old Arctic char exhibited rapid adaptive alterations of the hepatic lipidome to stepwise decreases in temperature while showing blunted responses to gradual increases in temperature, implying an inability to adapt rapidly to warmer environments. Three common phosphatidylethanolamines (PEs) (PE 36:6|PE 16:1_20:5, PE 38:7|PE 16:1_22:6, and PE 40:7|PE 18:1_22:6) were finally identified as candidate lipid biomarkers for temperature shifts via machine learning approach. Overall, this work provides additional information to a better understanding of underlying regulatory mechanisms of the lipidome of Arctic organisms in the face of near‐future warming. Article in Journal/Newspaper Arctic Climate change Salvelinus alpinus Wiley Online Library Arctic Global Change Biology 27 14 3282 3298 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high‐resolution mass‐spectrometry‐based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species—Arctic char ( Salvelinus alpinus )—with a detailed multi‐tissue analysis of the lipidome in response to chronic shifts in temperature using a validated lipidomics workflow. In addition, dynamic alterations in the hepatic lipidome during the time course of shifts in temperature were also characterized. Our results showed that early life stages of Arctic char were more susceptible to variations in temperature. One‐year‐old Arctic char responded to chronic increases in temperature with coordinated regulation of lipids, including headgroup‐specific remodeling of acyl chains in glycerophospholipids (GP) and extensive alterations in composition of lipids in membranes, such as less lyso‐GPs, and more ether‐GPs and sphingomyelin. Glycerolipids (e.g., triacylglycerol, TG) also participated in adaptive responses of the lipidome of Arctic char. Eight‐week‐old Arctic char exhibited rapid adaptive alterations of the hepatic lipidome to stepwise decreases in temperature while showing blunted responses to gradual increases in temperature, implying an inability to adapt rapidly to warmer environments. Three common phosphatidylethanolamines (PEs) (PE 36:6|PE 16:1_20:5, PE 38:7|PE 16:1_22:6, and PE 40:7|PE 18:1_22:6) were finally identified as candidate lipid biomarkers for temperature shifts via machine learning approach. Overall, this work provides additional information to a better understanding of underlying regulatory mechanisms of the lipidome of Arctic organisms in the face of near‐future warming. |
author2 |
Canada First Research Excellence Fund Natural Sciences and Engineering Research Council of Canada |
format |
Article in Journal/Newspaper |
author |
Wang, Chao Gong, Yufeng Deng, Fuchang Ding, Enmin Tang, Jie Codling, Garry Challis, Jonathan K. Green, Derek Wang, Jing Chen, Qiliang Xie, Yuwei Su, Shu Yang, Zilin Raine, Jason Jones, Paul D. Tang, Song Giesy, John P. |
spellingShingle |
Wang, Chao Gong, Yufeng Deng, Fuchang Ding, Enmin Tang, Jie Codling, Garry Challis, Jonathan K. Green, Derek Wang, Jing Chen, Qiliang Xie, Yuwei Su, Shu Yang, Zilin Raine, Jason Jones, Paul D. Tang, Song Giesy, John P. Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming |
author_facet |
Wang, Chao Gong, Yufeng Deng, Fuchang Ding, Enmin Tang, Jie Codling, Garry Challis, Jonathan K. Green, Derek Wang, Jing Chen, Qiliang Xie, Yuwei Su, Shu Yang, Zilin Raine, Jason Jones, Paul D. Tang, Song Giesy, John P. |
author_sort |
Wang, Chao |
title |
Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming |
title_short |
Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming |
title_full |
Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming |
title_fullStr |
Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming |
title_full_unstemmed |
Remodeling of Arctic char ( Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming |
title_sort |
remodeling of arctic char ( salvelinus alpinus) lipidome under a stimulated scenario of arctic warming |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1111/gcb.15638 https://onlinelibrary.wiley.com/doi/pdf/10.1111/gcb.15638 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/gcb.15638 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Climate change Salvelinus alpinus |
genre_facet |
Arctic Climate change Salvelinus alpinus |
op_source |
Global Change Biology volume 27, issue 14, page 3282-3298 ISSN 1354-1013 1365-2486 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/gcb.15638 |
container_title |
Global Change Biology |
container_volume |
27 |
container_issue |
14 |
container_start_page |
3282 |
op_container_end_page |
3298 |
_version_ |
1800744319805554688 |