Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus)
Abstract Population genetic theory posits that molecular variation buffers against disease risk. Although this “monoculture effect” is well supported in agricultural settings, its applicability to wildlife populations remains in question. In the present study, we examined the genomics underlying ind...
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crwiley:10.1111/eva.13127 2024-06-02T08:05:00+00:00 Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) DeCandia, Alexandra L. Schrom, Edward C. Brandell, Ellen E. Stahler, Daniel R. vonHoldt, Bridgett M. Center for Hierarchical Manufacturing, National Science Foundation 2020 http://dx.doi.org/10.1111/eva.13127 https://onlinelibrary.wiley.com/doi/pdf/10.1111/eva.13127 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/eva.13127 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Evolutionary Applications volume 14, issue 2, page 429-445 ISSN 1752-4571 1752-4571 journal-article 2020 crwiley https://doi.org/10.1111/eva.13127 2024-05-03T11:45:47Z Abstract Population genetic theory posits that molecular variation buffers against disease risk. Although this “monoculture effect” is well supported in agricultural settings, its applicability to wildlife populations remains in question. In the present study, we examined the genomics underlying individual‐level disease severity and population‐level consequences of sarcoptic mange infection in a wild population of canids. Using gray wolves ( Canis lupus ) reintroduced to Yellowstone National Park (YNP) as our focal system, we leveraged 25 years of observational data and biobanked blood and tissue to genotype 76,859 loci in over 400 wolves. At the individual level, we reported an inverse relationship between host genomic variation and infection severity. We additionally identified 410 loci significantly associated with mange severity, with annotations related to inflammation, immunity, and skin barrier integrity and disorders. We contextualized results within environmental, demographic, and behavioral variables, and confirmed that genetic variation was predictive of infection severity. At the population level, we reported decreased genome‐wide variation since the initial gray wolf reintroduction event and identified evidence of selection acting against alleles associated with mange infection severity. We concluded that genomic variation plays an important role in disease severity in YNP wolves. This role scales from individual to population levels, and includes patterns of genome‐wide variation in support of the monoculture effect and specific loci associated with the complex mange phenotype. Results yielded system‐specific insights, while also highlighting the relevance of genomic analyses to wildlife disease ecology, evolution, and conservation. Article in Journal/Newspaper Canis lupus gray wolf Wiley Online Library Evolutionary Applications 14 2 429 445 |
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English |
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Abstract Population genetic theory posits that molecular variation buffers against disease risk. Although this “monoculture effect” is well supported in agricultural settings, its applicability to wildlife populations remains in question. In the present study, we examined the genomics underlying individual‐level disease severity and population‐level consequences of sarcoptic mange infection in a wild population of canids. Using gray wolves ( Canis lupus ) reintroduced to Yellowstone National Park (YNP) as our focal system, we leveraged 25 years of observational data and biobanked blood and tissue to genotype 76,859 loci in over 400 wolves. At the individual level, we reported an inverse relationship between host genomic variation and infection severity. We additionally identified 410 loci significantly associated with mange severity, with annotations related to inflammation, immunity, and skin barrier integrity and disorders. We contextualized results within environmental, demographic, and behavioral variables, and confirmed that genetic variation was predictive of infection severity. At the population level, we reported decreased genome‐wide variation since the initial gray wolf reintroduction event and identified evidence of selection acting against alleles associated with mange infection severity. We concluded that genomic variation plays an important role in disease severity in YNP wolves. This role scales from individual to population levels, and includes patterns of genome‐wide variation in support of the monoculture effect and specific loci associated with the complex mange phenotype. Results yielded system‐specific insights, while also highlighting the relevance of genomic analyses to wildlife disease ecology, evolution, and conservation. |
author2 |
Center for Hierarchical Manufacturing, National Science Foundation |
format |
Article in Journal/Newspaper |
author |
DeCandia, Alexandra L. Schrom, Edward C. Brandell, Ellen E. Stahler, Daniel R. vonHoldt, Bridgett M. |
spellingShingle |
DeCandia, Alexandra L. Schrom, Edward C. Brandell, Ellen E. Stahler, Daniel R. vonHoldt, Bridgett M. Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) |
author_facet |
DeCandia, Alexandra L. Schrom, Edward C. Brandell, Ellen E. Stahler, Daniel R. vonHoldt, Bridgett M. |
author_sort |
DeCandia, Alexandra L. |
title |
Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) |
title_short |
Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) |
title_full |
Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) |
title_fullStr |
Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) |
title_full_unstemmed |
Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves ( Canis lupus) |
title_sort |
sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in yellowstone national park wolves ( canis lupus) |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1111/eva.13127 https://onlinelibrary.wiley.com/doi/pdf/10.1111/eva.13127 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/eva.13127 |
genre |
Canis lupus gray wolf |
genre_facet |
Canis lupus gray wolf |
op_source |
Evolutionary Applications volume 14, issue 2, page 429-445 ISSN 1752-4571 1752-4571 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1111/eva.13127 |
container_title |
Evolutionary Applications |
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14 |
container_issue |
2 |
container_start_page |
429 |
op_container_end_page |
445 |
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1800749732161650688 |