Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study
Aims To examine the associations between diastolic dysfunction indices and long‐term risk of all‐cause mortality in adults over 23‐year follow‐up. Methods and results Participants (n = 2734) of the population‐based Tromsø Study of Norway had echocardiography in 1994–1995. Of these 67% were repeated...
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Online Access: | http://dx.doi.org/10.1111/echo.14270 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fecho.14270 https://onlinelibrary.wiley.com/doi/pdf/10.1111/echo.14270 |
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crwiley:10.1111/echo.14270 2024-06-09T07:49:59+00:00 Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study Stylidis, Michael Sharashova, Ekaterina Wilsgaard, Tom Leon, David A. Heggelund, Geir Rösner, Assami Njølstad, Inger Løchen, Maja‐Lisa Schirmer, Henrik Universitetet i Tromsø London School of Hygiene and Tropical Medicine 2019 http://dx.doi.org/10.1111/echo.14270 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fecho.14270 https://onlinelibrary.wiley.com/doi/pdf/10.1111/echo.14270 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Echocardiography volume 36, issue 3, page 439-450 ISSN 0742-2822 1540-8175 journal-article 2019 crwiley https://doi.org/10.1111/echo.14270 2024-05-16T14:24:34Z Aims To examine the associations between diastolic dysfunction indices and long‐term risk of all‐cause mortality in adults over 23‐year follow‐up. Methods and results Participants (n = 2734) of the population‐based Tromsø Study of Norway had echocardiography in 1994–1995. Of these 67% were repeated in 2001 and/or 2007–2008. Mortality between 1994 and 2016 was determined by linkage to the national death registry. Cox regression was used to model the hazard of all‐cause mortality in relation to left atrial parameters (treated as time‐dependent using repeated measurements) adjusted for traditional risk factors and cardiovascular disease. During the follow‐up, 1399 participants died. Indexed left atrial diameter, mitral peak E deceleration time, and mitral peak E to peak A ratio showed an U‐shaped association with all‐cause mortality. Combining left atrial diameter with mitral peak E deceleration time increased the prognostic accuracy for all‐cause mortality whereas adding mitral peak E to peak A ratio did not increase prognostic value. We estimated new optimal cutoff values of left atrial diameter, mitral peak E deceleration time, and mitral peak E to peak A ratio for all‐cause mortality outcome. E/e′ had a cubic relation to mortality. Conclusion Both enlarged and small left atrial diameters were associated with increased all‐cause mortality risk. A combination of Doppler‐based left ventricle filling parameters had an incremental effect on all‐cause mortality risk. The cutoff values of diastolic dysfunction indices we determined had similar all‐cause mortality prediction ability as those recommended by American Association of Echocardiography and European Association of Cardiovascular Imaging. Article in Journal/Newspaper Tromsø Wiley Online Library Norway Tromsø Echocardiography 36 3 439 450 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Aims To examine the associations between diastolic dysfunction indices and long‐term risk of all‐cause mortality in adults over 23‐year follow‐up. Methods and results Participants (n = 2734) of the population‐based Tromsø Study of Norway had echocardiography in 1994–1995. Of these 67% were repeated in 2001 and/or 2007–2008. Mortality between 1994 and 2016 was determined by linkage to the national death registry. Cox regression was used to model the hazard of all‐cause mortality in relation to left atrial parameters (treated as time‐dependent using repeated measurements) adjusted for traditional risk factors and cardiovascular disease. During the follow‐up, 1399 participants died. Indexed left atrial diameter, mitral peak E deceleration time, and mitral peak E to peak A ratio showed an U‐shaped association with all‐cause mortality. Combining left atrial diameter with mitral peak E deceleration time increased the prognostic accuracy for all‐cause mortality whereas adding mitral peak E to peak A ratio did not increase prognostic value. We estimated new optimal cutoff values of left atrial diameter, mitral peak E deceleration time, and mitral peak E to peak A ratio for all‐cause mortality outcome. E/e′ had a cubic relation to mortality. Conclusion Both enlarged and small left atrial diameters were associated with increased all‐cause mortality risk. A combination of Doppler‐based left ventricle filling parameters had an incremental effect on all‐cause mortality risk. The cutoff values of diastolic dysfunction indices we determined had similar all‐cause mortality prediction ability as those recommended by American Association of Echocardiography and European Association of Cardiovascular Imaging. |
author2 |
Universitetet i Tromsø London School of Hygiene and Tropical Medicine |
format |
Article in Journal/Newspaper |
author |
Stylidis, Michael Sharashova, Ekaterina Wilsgaard, Tom Leon, David A. Heggelund, Geir Rösner, Assami Njølstad, Inger Løchen, Maja‐Lisa Schirmer, Henrik |
spellingShingle |
Stylidis, Michael Sharashova, Ekaterina Wilsgaard, Tom Leon, David A. Heggelund, Geir Rösner, Assami Njølstad, Inger Løchen, Maja‐Lisa Schirmer, Henrik Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study |
author_facet |
Stylidis, Michael Sharashova, Ekaterina Wilsgaard, Tom Leon, David A. Heggelund, Geir Rösner, Assami Njølstad, Inger Løchen, Maja‐Lisa Schirmer, Henrik |
author_sort |
Stylidis, Michael |
title |
Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study |
title_short |
Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study |
title_full |
Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study |
title_fullStr |
Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study |
title_full_unstemmed |
Left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: Results from the population‐based Tromsø Study |
title_sort |
left atrial diameter, left ventricle filling indices, and association with all‐cause mortality: results from the population‐based tromsø study |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1111/echo.14270 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fecho.14270 https://onlinelibrary.wiley.com/doi/pdf/10.1111/echo.14270 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Echocardiography volume 36, issue 3, page 439-450 ISSN 0742-2822 1540-8175 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/echo.14270 |
container_title |
Echocardiography |
container_volume |
36 |
container_issue |
3 |
container_start_page |
439 |
op_container_end_page |
450 |
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1801382927962996736 |