Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden
Aims Role of right atrial mechanics has not been studied in idiopathic pulmonary arterial hypertension ( IPAH ). We sought to investigate the correlation between the right sided, particularly right atrial mechanics, hemodynamic parameters, and functional capacity prior to initiation of treatment. Me...
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crwiley:10.1111/echo.12993 2024-06-02T08:12:13+00:00 Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden Saha, Samir Kanti Söderberg, Stefan Lindqvist, Per Northern County Council 2015 http://dx.doi.org/10.1111/echo.12993 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fecho.12993 https://onlinelibrary.wiley.com/doi/pdf/10.1111/echo.12993 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Echocardiography volume 33, issue 1, page 46-56 ISSN 0742-2822 1540-8175 journal-article 2015 crwiley https://doi.org/10.1111/echo.12993 2024-05-03T11:18:52Z Aims Role of right atrial mechanics has not been studied in idiopathic pulmonary arterial hypertension ( IPAH ). We sought to investigate the correlation between the right sided, particularly right atrial mechanics, hemodynamic parameters, and functional capacity prior to initiation of treatment. Methods and Results Twenty‐five subjects (63 ± 17 years, 13 males) with newly diagnosed IPAH by right heart catheterization ( RHC ) underwent speckle tracking echocardiography ( STE ) of the right ventricle ( RV ) and right atrium ( RA ). All the patients had a six‐minute walk test (6 MWD ) performed, functional class ( WHO ‐ FC ) assessed, and plasma NT ‐pro BNP estimated. STE strain imaging of RA and RV was performed offline. STE of the RA myocardium yielded characteristic strain (S%) and strain rate ( SR ) curves with clear delineation of its reservoir ( RA ‐ RS %), conduit ( RA ‐ SR E), and booster pump functions ( RA ‐ SR A). In IPAH , RHC ‐obtained pulmonary vascular resistance ( PVR ) and pulmonary artery systolic pressure ( PASP ), respectively, were 7.3 ± 5.6 Wood units and 66 ± 24 mmHg. RA ‐ RS % was associated negatively with PVR (r = −0.46; P < 0.05) and positively with stroke volume and cardiac output (all P < 0.05). Both right atrial pressure ( RAP ) obtained by RHC as well as RA ‐ SR E had significant association with WHO ‐ FC (Multiple R = 0.7; P = 0. 01 and 0.007, respectively). RA strain rate during systole and RAP had significant association with 6 MWD (Multiple R = 0.7; P = 0.01 and 0.006, respectively). Conclusion Right atrium mechanics not only correlate well with RHC ‐obtained hemodynamics, but also correlate with functional capacity in treatment‐naive IPAH . Article in Journal/Newspaper Northern Sweden Wiley Online Library Echocardiography 33 1 46 56 |
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Wiley Online Library |
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English |
description |
Aims Role of right atrial mechanics has not been studied in idiopathic pulmonary arterial hypertension ( IPAH ). We sought to investigate the correlation between the right sided, particularly right atrial mechanics, hemodynamic parameters, and functional capacity prior to initiation of treatment. Methods and Results Twenty‐five subjects (63 ± 17 years, 13 males) with newly diagnosed IPAH by right heart catheterization ( RHC ) underwent speckle tracking echocardiography ( STE ) of the right ventricle ( RV ) and right atrium ( RA ). All the patients had a six‐minute walk test (6 MWD ) performed, functional class ( WHO ‐ FC ) assessed, and plasma NT ‐pro BNP estimated. STE strain imaging of RA and RV was performed offline. STE of the RA myocardium yielded characteristic strain (S%) and strain rate ( SR ) curves with clear delineation of its reservoir ( RA ‐ RS %), conduit ( RA ‐ SR E), and booster pump functions ( RA ‐ SR A). In IPAH , RHC ‐obtained pulmonary vascular resistance ( PVR ) and pulmonary artery systolic pressure ( PASP ), respectively, were 7.3 ± 5.6 Wood units and 66 ± 24 mmHg. RA ‐ RS % was associated negatively with PVR (r = −0.46; P < 0.05) and positively with stroke volume and cardiac output (all P < 0.05). Both right atrial pressure ( RAP ) obtained by RHC as well as RA ‐ SR E had significant association with WHO ‐ FC (Multiple R = 0.7; P = 0. 01 and 0.007, respectively). RA strain rate during systole and RAP had significant association with 6 MWD (Multiple R = 0.7; P = 0.01 and 0.006, respectively). Conclusion Right atrium mechanics not only correlate well with RHC ‐obtained hemodynamics, but also correlate with functional capacity in treatment‐naive IPAH . |
author2 |
Northern County Council |
format |
Article in Journal/Newspaper |
author |
Saha, Samir Kanti Söderberg, Stefan Lindqvist, Per |
spellingShingle |
Saha, Samir Kanti Söderberg, Stefan Lindqvist, Per Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden |
author_facet |
Saha, Samir Kanti Söderberg, Stefan Lindqvist, Per |
author_sort |
Saha, Samir Kanti |
title |
Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden |
title_short |
Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden |
title_full |
Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden |
title_fullStr |
Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden |
title_full_unstemmed |
Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single‐Center Cohort in Northern Sweden |
title_sort |
association of right atrial mechanics with hemodynamics and physical capacity in patients with idiopathic pulmonary arterial hypertension: insight from a single‐center cohort in northern sweden |
publisher |
Wiley |
publishDate |
2015 |
url |
http://dx.doi.org/10.1111/echo.12993 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fecho.12993 https://onlinelibrary.wiley.com/doi/pdf/10.1111/echo.12993 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Echocardiography volume 33, issue 1, page 46-56 ISSN 0742-2822 1540-8175 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/echo.12993 |
container_title |
Echocardiography |
container_volume |
33 |
container_issue |
1 |
container_start_page |
46 |
op_container_end_page |
56 |
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1800758587906064384 |