Evaluation of a population‐based approach to familial colorectal cancer
As Newfoundland has the highest rate of familial colorectal cancer ( CRC ) in the world, we started a population‐based clinic to provide colonoscopic and Lynch syndrome ( LS ) screening recommendations to families of CRC patients based on family risk. Of 1091 incident patients 51% provided a family...
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Online Access: | http://dx.doi.org/10.1111/cge.12877 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcge.12877 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cge.12877 |
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crwiley:10.1111/cge.12877 2024-06-02T08:10:44+00:00 Evaluation of a population‐based approach to familial colorectal cancer Parfrey, P.S. Dicks, E. Parfrey, O. McNicholas, P.J. Noseworthy, H. Woods, M.O. Negriin, C. Green, J. Department of Health, Australian Government Canadian Institutes of Health Research Department of Health 2017 http://dx.doi.org/10.1111/cge.12877 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcge.12877 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cge.12877 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Clinical Genetics volume 91, issue 5, page 672-682 ISSN 0009-9163 1399-0004 journal-article 2017 crwiley https://doi.org/10.1111/cge.12877 2024-05-03T11:37:52Z As Newfoundland has the highest rate of familial colorectal cancer ( CRC ) in the world, we started a population‐based clinic to provide colonoscopic and Lynch syndrome ( LS ) screening recommendations to families of CRC patients based on family risk. Of 1091 incident patients 51% provided a family history. Seventy‐two percent of families were at low or intermediate–low risk of CRC and colonoscopic screening recommendations were provided by letter. Twenty‐eight percent were at high and intermediate–high risk and were referred to the genetic counsellor, but only 30% ( N = 48) were interviewed by study end. Colonoscopy was recommended more frequently than every 5 years in 35% of families. Lower family risk was associated with older age of proband but the frequency of screening colonoscopy recommendations varied across all age groups, driven by variability in family history. Twenty‐four percent had a high MMR predict score for a Lynch syndrome mutation, and 23% fulfilled the Provincial Program criteria for LS screening. A population‐based approach in the provision of colonoscopic screening recommendations to families at risk of CRC was limited by the relatively low response rate. A family history first approach to the identification of LS families was inefficient. Article in Journal/Newspaper Newfoundland Wiley Online Library Lynch ENVELOPE(-57.683,-57.683,-63.783,-63.783) Clinical Genetics 91 5 672 682 |
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Wiley Online Library |
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English |
description |
As Newfoundland has the highest rate of familial colorectal cancer ( CRC ) in the world, we started a population‐based clinic to provide colonoscopic and Lynch syndrome ( LS ) screening recommendations to families of CRC patients based on family risk. Of 1091 incident patients 51% provided a family history. Seventy‐two percent of families were at low or intermediate–low risk of CRC and colonoscopic screening recommendations were provided by letter. Twenty‐eight percent were at high and intermediate–high risk and were referred to the genetic counsellor, but only 30% ( N = 48) were interviewed by study end. Colonoscopy was recommended more frequently than every 5 years in 35% of families. Lower family risk was associated with older age of proband but the frequency of screening colonoscopy recommendations varied across all age groups, driven by variability in family history. Twenty‐four percent had a high MMR predict score for a Lynch syndrome mutation, and 23% fulfilled the Provincial Program criteria for LS screening. A population‐based approach in the provision of colonoscopic screening recommendations to families at risk of CRC was limited by the relatively low response rate. A family history first approach to the identification of LS families was inefficient. |
author2 |
Department of Health, Australian Government Canadian Institutes of Health Research Department of Health |
format |
Article in Journal/Newspaper |
author |
Parfrey, P.S. Dicks, E. Parfrey, O. McNicholas, P.J. Noseworthy, H. Woods, M.O. Negriin, C. Green, J. |
spellingShingle |
Parfrey, P.S. Dicks, E. Parfrey, O. McNicholas, P.J. Noseworthy, H. Woods, M.O. Negriin, C. Green, J. Evaluation of a population‐based approach to familial colorectal cancer |
author_facet |
Parfrey, P.S. Dicks, E. Parfrey, O. McNicholas, P.J. Noseworthy, H. Woods, M.O. Negriin, C. Green, J. |
author_sort |
Parfrey, P.S. |
title |
Evaluation of a population‐based approach to familial colorectal cancer |
title_short |
Evaluation of a population‐based approach to familial colorectal cancer |
title_full |
Evaluation of a population‐based approach to familial colorectal cancer |
title_fullStr |
Evaluation of a population‐based approach to familial colorectal cancer |
title_full_unstemmed |
Evaluation of a population‐based approach to familial colorectal cancer |
title_sort |
evaluation of a population‐based approach to familial colorectal cancer |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1111/cge.12877 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcge.12877 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cge.12877 |
long_lat |
ENVELOPE(-57.683,-57.683,-63.783,-63.783) |
geographic |
Lynch |
geographic_facet |
Lynch |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Clinical Genetics volume 91, issue 5, page 672-682 ISSN 0009-9163 1399-0004 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1111/cge.12877 |
container_title |
Clinical Genetics |
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91 |
container_issue |
5 |
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672 |
op_container_end_page |
682 |
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1800756645735694336 |