Environmental risk factors related to the incidence of wheeze and asthma in adolescence
Summary Background Asthma is common among adolescents, but there are few population‐based studies on the risk factors for incident asthma and wheeze at this age group. Objective To study risk factors for incident asthma and wheeze in adolescence. Method Within the Obstructive Lung Disease In Norther...
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crwiley:10.1111/cea.12335 2024-09-15T18:26:12+00:00 Environmental risk factors related to the incidence of wheeze and asthma in adolescence Hedman, L. Andersson, M. Bjerg, A. Forsberg, B. Lundbäck, B. Rönmark, E. ALK Glaxosmithkline world wide epidemiology Norrbotten County Council Swedish Heart Lung Foundation The Swedish Asthma and Allergy Associations Research Foundation The Swedish Foundation for Health Care Science and Allergy Research (V�rdal) The Swedish Research Council ThermoFisher Visare Norr V�sterbotten county council 2014 http://dx.doi.org/10.1111/cea.12335 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcea.12335 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cea.12335 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Clinical & Experimental Allergy volume 45, issue 1, page 184-191 ISSN 0954-7894 1365-2222 journal-article 2014 crwiley https://doi.org/10.1111/cea.12335 2024-08-09T04:25:39Z Summary Background Asthma is common among adolescents, but there are few population‐based studies on the risk factors for incident asthma and wheeze at this age group. Objective To study risk factors for incident asthma and wheeze in adolescence. Method Within the Obstructive Lung Disease In Northern Sweden ( OLIN ) studies, a cohort of 3430 school children (age 7–8 year) was recruited in 1996. In the present study, this cohort was followed from age 12–19 year. At baseline (age 12 year), 3151 participated and skin prick tests ( SPT ) were performed. The cohort was resurveyed annually, and risk factors for the cumulative incidence of asthma and wheeze from age 12–19 year were analysed using multivariate Cox regression. Results Female sex (wheeze: HR 1.4 95% CI 1.2–1.6; asthma: HR 1.8 95% CI 1.2–2.5) and a positive SPT to cat, dog or horse at baseline (wheeze: HR 1.6 95% CI 1.2–2.1; asthma: HR 2.3 95% CI 1.4–4.0) were significantly associated with the cumulative incidence of wheeze and asthma. Increasing numbers of siblings were inversely related to the incidence of wheeze ( HR 0.9 95% CI 0.8–0.97) and asthma ( HR 0.8 95% CI 0.7–0.97). Parental asthma was related to the incidence of asthma ( HR 1.8 95% CI 1.2–2.6) while ever smoking ( HR 2.0 95% CI 1.6–2.4) and house dampness ( HR 1.3 95% CI 1.1–1.6) were risk factors for the incidence of wheeze. Maternal ETS exposure increased the risk of incident asthma in non‐sensitized subjects ( HR 1.9 95% CI 1.0–3.7). Conclusion and clinical relevance Several environmental risk factors related to the incidence of asthma and wheeze in adolescence were identified and may be possible targets for intervention and prevention. Article in Journal/Newspaper Northern Sweden Wiley Online Library Clinical & Experimental Allergy 45 1 184 191 |
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language |
English |
description |
Summary Background Asthma is common among adolescents, but there are few population‐based studies on the risk factors for incident asthma and wheeze at this age group. Objective To study risk factors for incident asthma and wheeze in adolescence. Method Within the Obstructive Lung Disease In Northern Sweden ( OLIN ) studies, a cohort of 3430 school children (age 7–8 year) was recruited in 1996. In the present study, this cohort was followed from age 12–19 year. At baseline (age 12 year), 3151 participated and skin prick tests ( SPT ) were performed. The cohort was resurveyed annually, and risk factors for the cumulative incidence of asthma and wheeze from age 12–19 year were analysed using multivariate Cox regression. Results Female sex (wheeze: HR 1.4 95% CI 1.2–1.6; asthma: HR 1.8 95% CI 1.2–2.5) and a positive SPT to cat, dog or horse at baseline (wheeze: HR 1.6 95% CI 1.2–2.1; asthma: HR 2.3 95% CI 1.4–4.0) were significantly associated with the cumulative incidence of wheeze and asthma. Increasing numbers of siblings were inversely related to the incidence of wheeze ( HR 0.9 95% CI 0.8–0.97) and asthma ( HR 0.8 95% CI 0.7–0.97). Parental asthma was related to the incidence of asthma ( HR 1.8 95% CI 1.2–2.6) while ever smoking ( HR 2.0 95% CI 1.6–2.4) and house dampness ( HR 1.3 95% CI 1.1–1.6) were risk factors for the incidence of wheeze. Maternal ETS exposure increased the risk of incident asthma in non‐sensitized subjects ( HR 1.9 95% CI 1.0–3.7). Conclusion and clinical relevance Several environmental risk factors related to the incidence of asthma and wheeze in adolescence were identified and may be possible targets for intervention and prevention. |
author2 |
ALK Glaxosmithkline world wide epidemiology Norrbotten County Council Swedish Heart Lung Foundation The Swedish Asthma and Allergy Associations Research Foundation The Swedish Foundation for Health Care Science and Allergy Research (V�rdal) The Swedish Research Council ThermoFisher Visare Norr V�sterbotten county council |
format |
Article in Journal/Newspaper |
author |
Hedman, L. Andersson, M. Bjerg, A. Forsberg, B. Lundbäck, B. Rönmark, E. |
spellingShingle |
Hedman, L. Andersson, M. Bjerg, A. Forsberg, B. Lundbäck, B. Rönmark, E. Environmental risk factors related to the incidence of wheeze and asthma in adolescence |
author_facet |
Hedman, L. Andersson, M. Bjerg, A. Forsberg, B. Lundbäck, B. Rönmark, E. |
author_sort |
Hedman, L. |
title |
Environmental risk factors related to the incidence of wheeze and asthma in adolescence |
title_short |
Environmental risk factors related to the incidence of wheeze and asthma in adolescence |
title_full |
Environmental risk factors related to the incidence of wheeze and asthma in adolescence |
title_fullStr |
Environmental risk factors related to the incidence of wheeze and asthma in adolescence |
title_full_unstemmed |
Environmental risk factors related to the incidence of wheeze and asthma in adolescence |
title_sort |
environmental risk factors related to the incidence of wheeze and asthma in adolescence |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1111/cea.12335 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcea.12335 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cea.12335 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Clinical & Experimental Allergy volume 45, issue 1, page 184-191 ISSN 0954-7894 1365-2222 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/cea.12335 |
container_title |
Clinical & Experimental Allergy |
container_volume |
45 |
container_issue |
1 |
container_start_page |
184 |
op_container_end_page |
191 |
_version_ |
1810466649344573440 |