DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women
Abstract Several studies have found aberrant DNA methylation levels in breast cancer cases, but factors influencing DNA methylation patterns and the mechanisms are not well understood. This case–control study evaluated blood methylation level of two repetitive elements and selected breast cancer‐rel...
Published in: | Basic & Clinical Pharmacology & Toxicology |
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crwiley:10.1111/bcpt.13424 2024-09-15T18:10:16+00:00 DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women Wielsøe, Maria Tarantini, Letizia Bollati, Valentina Long, Manhai Bonefeld‐Jørgensen, Eva Cecilie 2020 http://dx.doi.org/10.1111/bcpt.13424 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbcpt.13424 https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.13424 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bcpt.13424 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Basic & Clinical Pharmacology & Toxicology volume 127, issue 4, page 338-350 ISSN 1742-7835 1742-7843 journal-article 2020 crwiley https://doi.org/10.1111/bcpt.13424 2024-07-09T04:14:52Z Abstract Several studies have found aberrant DNA methylation levels in breast cancer cases, but factors influencing DNA methylation patterns and the mechanisms are not well understood. This case–control study evaluated blood methylation level of two repetitive elements and selected breast cancer‐related genes in relation to breast cancer risk, and the associations with serum level of persistent organic pollutants (POPs) and breast cancer risk factors in Greenlandic Inuit. DNA methylation was determined using bisulphite pyrosequencing in blood from 74 breast cancer cases and 80 controls. Using first tertile as reference, the following was observed. Positive associations for ATM in second tertile (OR: 2.33, 95% CI: 1.04; 5.23) and ESR2 in third tertile (OR: 2.22, 95% CI: 0.97; 5.05) suggest an increased breast cancer risk with high DNA methylation. LINE‐1 methylation was lower in cases than controls. In third tertile (OR: 0.42, 95% CI: 0.18; 0.98), associations suggest in accordance with the literature an increased risk of breast cancer with LINE‐1 hypo methylation. Among controls, significant associations between methylation levels and serum level of POPs and breast cancer risk factors (age, body mass index, cotinine level) were found. Thus, breast cancer risk factors and POPs may alter the risk through changes in methylation levels; further studies are needed to elucidate the mechanisms. Article in Journal/Newspaper greenlandic inuit Wiley Online Library Basic & Clinical Pharmacology & Toxicology 127 4 338 350 |
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Abstract Several studies have found aberrant DNA methylation levels in breast cancer cases, but factors influencing DNA methylation patterns and the mechanisms are not well understood. This case–control study evaluated blood methylation level of two repetitive elements and selected breast cancer‐related genes in relation to breast cancer risk, and the associations with serum level of persistent organic pollutants (POPs) and breast cancer risk factors in Greenlandic Inuit. DNA methylation was determined using bisulphite pyrosequencing in blood from 74 breast cancer cases and 80 controls. Using first tertile as reference, the following was observed. Positive associations for ATM in second tertile (OR: 2.33, 95% CI: 1.04; 5.23) and ESR2 in third tertile (OR: 2.22, 95% CI: 0.97; 5.05) suggest an increased breast cancer risk with high DNA methylation. LINE‐1 methylation was lower in cases than controls. In third tertile (OR: 0.42, 95% CI: 0.18; 0.98), associations suggest in accordance with the literature an increased risk of breast cancer with LINE‐1 hypo methylation. Among controls, significant associations between methylation levels and serum level of POPs and breast cancer risk factors (age, body mass index, cotinine level) were found. Thus, breast cancer risk factors and POPs may alter the risk through changes in methylation levels; further studies are needed to elucidate the mechanisms. |
format |
Article in Journal/Newspaper |
author |
Wielsøe, Maria Tarantini, Letizia Bollati, Valentina Long, Manhai Bonefeld‐Jørgensen, Eva Cecilie |
spellingShingle |
Wielsøe, Maria Tarantini, Letizia Bollati, Valentina Long, Manhai Bonefeld‐Jørgensen, Eva Cecilie DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women |
author_facet |
Wielsøe, Maria Tarantini, Letizia Bollati, Valentina Long, Manhai Bonefeld‐Jørgensen, Eva Cecilie |
author_sort |
Wielsøe, Maria |
title |
DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women |
title_short |
DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women |
title_full |
DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women |
title_fullStr |
DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women |
title_full_unstemmed |
DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women |
title_sort |
dna methylation level in blood and relations to breast cancer, risk factors and environmental exposure in greenlandic inuit women |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1111/bcpt.13424 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbcpt.13424 https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.13424 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bcpt.13424 |
genre |
greenlandic inuit |
genre_facet |
greenlandic inuit |
op_source |
Basic & Clinical Pharmacology & Toxicology volume 127, issue 4, page 338-350 ISSN 1742-7835 1742-7843 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1111/bcpt.13424 |
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Basic & Clinical Pharmacology & Toxicology |
container_volume |
127 |
container_issue |
4 |
container_start_page |
338 |
op_container_end_page |
350 |
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1810447858283839488 |