FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services
We have evaluated the performance of FilmArray BCID2 in reactive blood cultures in a small acute care hospital compared to conventional diagnostics at a regional microbiological laboratory. This is a retrospective observational study of BactAlert reactive blood cultures ( n = 160) from Helgeland Hos...
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crwiley:10.1111/apm.13374 2024-06-02T08:07:50+00:00 FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services Harboe‐Sjåvik, Hege Endresen, Kristoffer Hammer Åsheim, Sandra Sundsfjord, Arnfinn 2024 http://dx.doi.org/10.1111/apm.13374 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.13374 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ APMIS volume 132, issue 4, page 267-276 ISSN 0903-4641 1600-0463 journal-article 2024 crwiley https://doi.org/10.1111/apm.13374 2024-05-03T11:31:01Z We have evaluated the performance of FilmArray BCID2 in reactive blood cultures in a small acute care hospital compared to conventional diagnostics at a regional microbiological laboratory. This is a retrospective observational study of BactAlert reactive blood cultures ( n = 160) from Helgeland Hospital, July–December 2021, analysed by BCID2 locally and conventional culture at a regional laboratory. The overall clinical and analytic sensitivity with BCID2 were 87.2% and 97.8%, respectively. The false‐negative BCID2 rate was low ( n = 4; 2.9%). No false‐positive BCID2 results were observed. The BCID2 data were available on average 1.88 days earlier than culture‐based results, due to long transport time to the regional laboratory. The BCID2 provided results to support a significantly earlier optimized targeted antibiotic treatment in 27% of the cases according to national guidelines for empirical treatment of BSI. The high clinical and analytical sensitivity, and specificity support the use of BCID2 as a robust supplement to traditional cultivation of positive blood cultures. The significant time gain to microbial identification and detection of resistance determinants suggests a great clinical importance of BCID2 in small acute care hospitals with long transport time to conventional clinical microbiology services. Article in Journal/Newspaper Helgeland Wiley Online Library Helgeland APMIS 132 4 267 276 |
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English |
description |
We have evaluated the performance of FilmArray BCID2 in reactive blood cultures in a small acute care hospital compared to conventional diagnostics at a regional microbiological laboratory. This is a retrospective observational study of BactAlert reactive blood cultures ( n = 160) from Helgeland Hospital, July–December 2021, analysed by BCID2 locally and conventional culture at a regional laboratory. The overall clinical and analytic sensitivity with BCID2 were 87.2% and 97.8%, respectively. The false‐negative BCID2 rate was low ( n = 4; 2.9%). No false‐positive BCID2 results were observed. The BCID2 data were available on average 1.88 days earlier than culture‐based results, due to long transport time to the regional laboratory. The BCID2 provided results to support a significantly earlier optimized targeted antibiotic treatment in 27% of the cases according to national guidelines for empirical treatment of BSI. The high clinical and analytical sensitivity, and specificity support the use of BCID2 as a robust supplement to traditional cultivation of positive blood cultures. The significant time gain to microbial identification and detection of resistance determinants suggests a great clinical importance of BCID2 in small acute care hospitals with long transport time to conventional clinical microbiology services. |
format |
Article in Journal/Newspaper |
author |
Harboe‐Sjåvik, Hege Endresen, Kristoffer Hammer Åsheim, Sandra Sundsfjord, Arnfinn |
spellingShingle |
Harboe‐Sjåvik, Hege Endresen, Kristoffer Hammer Åsheim, Sandra Sundsfjord, Arnfinn FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
author_facet |
Harboe‐Sjåvik, Hege Endresen, Kristoffer Hammer Åsheim, Sandra Sundsfjord, Arnfinn |
author_sort |
Harboe‐Sjåvik, Hege |
title |
FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
title_short |
FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
title_full |
FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
title_fullStr |
FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
title_full_unstemmed |
FilmArray ( BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
title_sort |
filmarray ( bcid2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services |
publisher |
Wiley |
publishDate |
2024 |
url |
http://dx.doi.org/10.1111/apm.13374 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.13374 |
geographic |
Helgeland |
geographic_facet |
Helgeland |
genre |
Helgeland |
genre_facet |
Helgeland |
op_source |
APMIS volume 132, issue 4, page 267-276 ISSN 0903-4641 1600-0463 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1111/apm.13374 |
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132 |
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4 |
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267 |
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276 |
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1800752969402023936 |