Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma
Adenocarcinoma is the most common histological type of lung carcinoma. Recently the histologic classification of adenocarcinomas in the lung was modified to better reflect biologic properties and prognosis. We reviewed the histology of all primary lung adenocarcinomas operated on in Iceland during a...
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crwiley:10.1111/apm.12522 2024-06-23T07:53:58+00:00 Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma Oskarsdottir, Gudrun Nina Bjornsson, Johannes Jonsson, Steinn Isaksson, Helgi J Gudbjartsson, Tomas Landspitali University Research Fund University of Iceland Research Fund 2016 http://dx.doi.org/10.1111/apm.12522 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapm.12522 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12522 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor APMIS volume 124, issue 5, page 384-392 ISSN 0903-4641 1600-0463 journal-article 2016 crwiley https://doi.org/10.1111/apm.12522 2024-05-31T08:12:07Z Adenocarcinoma is the most common histological type of lung carcinoma. Recently the histologic classification of adenocarcinomas in the lung was modified to better reflect biologic properties and prognosis. We reviewed the histology of all primary lung adenocarcinomas operated on in Iceland during a 20‐year period and assessed the impact of histology on survival. This nationwide study included 285 patients (mean age 67 years, 57% female), who underwent resection in Iceland from 1991 to 2010. Tumors were reclassified according to the current IASLC / ATS / ERS classification system. Overall survival was estimated by the Kaplan–Meier method and Cox regression analysis used to evaluate prognostic factors of overall mortality. Acinar predominant adenocarcinoma was the most common histological subtype (46%) followed by solid‐predominant ( SPA ) with mucin production comprised (23%). Non‐invasive carcinomas were rare. A difference in survival between the histological adenocarcinoma subtypes was not seen (p = 0.32) and multivariate analysis showed that advanced stage and age predicted worse outcome, but histologic subtyping of adenocarcinoma did not. In this nation‐wide study there was not a statistical difference in survival according to adenocarcinoma subtypes and the histological subtype did not predict mortality. Preinvasive and minimally invasive adenocarcinomas were rare. Article in Journal/Newspaper Iceland Wiley Online Library Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) APMIS 124 5 384 392 |
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Wiley Online Library |
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crwiley |
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English |
description |
Adenocarcinoma is the most common histological type of lung carcinoma. Recently the histologic classification of adenocarcinomas in the lung was modified to better reflect biologic properties and prognosis. We reviewed the histology of all primary lung adenocarcinomas operated on in Iceland during a 20‐year period and assessed the impact of histology on survival. This nationwide study included 285 patients (mean age 67 years, 57% female), who underwent resection in Iceland from 1991 to 2010. Tumors were reclassified according to the current IASLC / ATS / ERS classification system. Overall survival was estimated by the Kaplan–Meier method and Cox regression analysis used to evaluate prognostic factors of overall mortality. Acinar predominant adenocarcinoma was the most common histological subtype (46%) followed by solid‐predominant ( SPA ) with mucin production comprised (23%). Non‐invasive carcinomas were rare. A difference in survival between the histological adenocarcinoma subtypes was not seen (p = 0.32) and multivariate analysis showed that advanced stage and age predicted worse outcome, but histologic subtyping of adenocarcinoma did not. In this nation‐wide study there was not a statistical difference in survival according to adenocarcinoma subtypes and the histological subtype did not predict mortality. Preinvasive and minimally invasive adenocarcinomas were rare. |
author2 |
Landspitali University Research Fund University of Iceland Research Fund |
format |
Article in Journal/Newspaper |
author |
Oskarsdottir, Gudrun Nina Bjornsson, Johannes Jonsson, Steinn Isaksson, Helgi J Gudbjartsson, Tomas |
spellingShingle |
Oskarsdottir, Gudrun Nina Bjornsson, Johannes Jonsson, Steinn Isaksson, Helgi J Gudbjartsson, Tomas Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma |
author_facet |
Oskarsdottir, Gudrun Nina Bjornsson, Johannes Jonsson, Steinn Isaksson, Helgi J Gudbjartsson, Tomas |
author_sort |
Oskarsdottir, Gudrun Nina |
title |
Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma |
title_short |
Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma |
title_full |
Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma |
title_fullStr |
Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma |
title_full_unstemmed |
Primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the IASLC/ ATS/ ERS classification of lung adenocarcinoma |
title_sort |
primary adenocarcinoma of the lung – histological subtypes and outcome after surgery, using the iaslc/ ats/ ers classification of lung adenocarcinoma |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/apm.12522 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapm.12522 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12522 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Meier |
geographic_facet |
Meier |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
APMIS volume 124, issue 5, page 384-392 ISSN 0903-4641 1600-0463 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/apm.12522 |
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APMIS |
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124 |
container_issue |
5 |
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384 |
op_container_end_page |
392 |
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1802645880657936384 |