Colon cancer: association of histopathological parameters and patients' survival with clinical presentation
Available data correlating symptoms of colon cancer patients with the severity of the disease are very limited. In a population‐based setting, we correlated information on symptoms of colon cancer patients with several pathological tumor parameters and survival. Information on all patients diagnosed...
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crwiley:10.1111/apm.12109 2024-09-15T18:14:18+00:00 Colon cancer: association of histopathological parameters and patients' survival with clinical presentation Alexiusdottir, Kristin K. Snaebjornsson, Petur Tryggvadottir, Laufey Jonasson, Larus Olafsdottir, Elinborg J. Björnsson, Einar Stefan Möller, Pall Helgi Jonasson, Jon G. 2013 http://dx.doi.org/10.1111/apm.12109 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapm.12109 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12109 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor APMIS volume 121, issue 10, page 901-907 ISSN 0903-4641 1600-0463 journal-article 2013 crwiley https://doi.org/10.1111/apm.12109 2024-07-30T04:20:42Z Available data correlating symptoms of colon cancer patients with the severity of the disease are very limited. In a population‐based setting, we correlated information on symptoms of colon cancer patients with several pathological tumor parameters and survival. Information on all patients diagnosed with colon cancer in Iceland in 1995–2004 for this retrospective, population‐based study was obtained from the Icelandic Cancer Registry. Information on symptoms of patients and blood hemoglobin was collected from patients' files. Pathological parameters were obtained from a previously performed standardized tumor review. A total of 768 patients entered this study; the median age was 73 years. Tumors in patients presenting at diagnosis with visible blood in stools were significantly more likely to be of lower grade, having pushing border, conspicuous peritumoral lymphocytic infiltration, and lower frequency of vessel invasion. Patients with abdominal pain and anemia were significantly more likely to have vessel invasion. Logistic regression showed that visible blood in stools was significantly associated with protecting pathological factors ( OR range 0.38–0.83, p < 0.05). Tumors in patients presenting with abdominal pain were strongly associated with infiltrative margin and scarce peritumoral lymphocytic infiltration ( OR = 1.95; 2.18 respectively, p < 0.05). Changes in bowel habits were strongly associated with vessel invasion ( OR = 2.03, p < 0.05). Cox regression showed that blood in stools predicted survival ( HR = 0.54). In conclusion, visible blood in stools correlates significantly with all the beneficial pathological parameters analyzed and with better survival of patients. Anemia, general symptoms, changes in bowel habits, acute symptoms, and abdominal pain correlate with more aggressive tumor characteristics and adverse outcome for patients. Article in Journal/Newspaper Iceland Wiley Online Library APMIS 121 10 901 907 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Available data correlating symptoms of colon cancer patients with the severity of the disease are very limited. In a population‐based setting, we correlated information on symptoms of colon cancer patients with several pathological tumor parameters and survival. Information on all patients diagnosed with colon cancer in Iceland in 1995–2004 for this retrospective, population‐based study was obtained from the Icelandic Cancer Registry. Information on symptoms of patients and blood hemoglobin was collected from patients' files. Pathological parameters were obtained from a previously performed standardized tumor review. A total of 768 patients entered this study; the median age was 73 years. Tumors in patients presenting at diagnosis with visible blood in stools were significantly more likely to be of lower grade, having pushing border, conspicuous peritumoral lymphocytic infiltration, and lower frequency of vessel invasion. Patients with abdominal pain and anemia were significantly more likely to have vessel invasion. Logistic regression showed that visible blood in stools was significantly associated with protecting pathological factors ( OR range 0.38–0.83, p < 0.05). Tumors in patients presenting with abdominal pain were strongly associated with infiltrative margin and scarce peritumoral lymphocytic infiltration ( OR = 1.95; 2.18 respectively, p < 0.05). Changes in bowel habits were strongly associated with vessel invasion ( OR = 2.03, p < 0.05). Cox regression showed that blood in stools predicted survival ( HR = 0.54). In conclusion, visible blood in stools correlates significantly with all the beneficial pathological parameters analyzed and with better survival of patients. Anemia, general symptoms, changes in bowel habits, acute symptoms, and abdominal pain correlate with more aggressive tumor characteristics and adverse outcome for patients. |
format |
Article in Journal/Newspaper |
author |
Alexiusdottir, Kristin K. Snaebjornsson, Petur Tryggvadottir, Laufey Jonasson, Larus Olafsdottir, Elinborg J. Björnsson, Einar Stefan Möller, Pall Helgi Jonasson, Jon G. |
spellingShingle |
Alexiusdottir, Kristin K. Snaebjornsson, Petur Tryggvadottir, Laufey Jonasson, Larus Olafsdottir, Elinborg J. Björnsson, Einar Stefan Möller, Pall Helgi Jonasson, Jon G. Colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
author_facet |
Alexiusdottir, Kristin K. Snaebjornsson, Petur Tryggvadottir, Laufey Jonasson, Larus Olafsdottir, Elinborg J. Björnsson, Einar Stefan Möller, Pall Helgi Jonasson, Jon G. |
author_sort |
Alexiusdottir, Kristin K. |
title |
Colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
title_short |
Colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
title_full |
Colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
title_fullStr |
Colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
title_full_unstemmed |
Colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
title_sort |
colon cancer: association of histopathological parameters and patients' survival with clinical presentation |
publisher |
Wiley |
publishDate |
2013 |
url |
http://dx.doi.org/10.1111/apm.12109 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapm.12109 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12109 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
APMIS volume 121, issue 10, page 901-907 ISSN 0903-4641 1600-0463 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/apm.12109 |
container_title |
APMIS |
container_volume |
121 |
container_issue |
10 |
container_start_page |
901 |
op_container_end_page |
907 |
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1810452075390173184 |