Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood
Abstract Aim The survival rate after treatment for childhood leukaemia has greatly improved, but could result in protracted immune deficiency. This study examined the immune status of children after chemotherapy and evaluated their responses to immunisation. Methods Subjects who had completed their...
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crwiley:10.1111/apa.17070 2024-06-02T08:09:21+00:00 Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood Óskarsson, Ýmir Thors, Valtýr Vias, Rafael Daníel Lúðvíksson, Björn Rúnar Brynjólfsson, Siggeir Fannar Gianchecchi, Elena Razzano, Ilaria Montomoli, Emanuele Gísli Jónsson, Ólafur Haraldsson, Ásgeir 2023 http://dx.doi.org/10.1111/apa.17070 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.17070 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Paediatrica volume 113, issue 3, page 606-614 ISSN 0803-5253 1651-2227 journal-article 2023 crwiley https://doi.org/10.1111/apa.17070 2024-05-03T10:54:16Z Abstract Aim The survival rate after treatment for childhood leukaemia has greatly improved, but could result in protracted immune deficiency. This study examined the immune status of children after chemotherapy and evaluated their responses to immunisation. Methods Subjects who had completed their treatment for acute lymphoblastic leukaemia at The Children's Hospital Reykjavík, Iceland, during 2011–2020 had blood drawn and were then immunised for influenza in October 2021. Blood was drawn again 4 weeks later and their humoral and cellular responses were measured with a haemagglutination inhibition assay and lymphocyte stimulation test. Antibodies to other immunisations were also evaluated. Results We studied 18 patients (10 male) who had completed their treatment at 3.7–20.3 years of age (mean 9.1), 11–84 months (mean 36.9) before enrolment. Conventional immunological evaluation did not reveal notable abnormalities. The responses to several childhood vaccinations, including the pneumococcal conjugate vaccination, were adequate in most patients. Humoral responses to the influenza vaccine confirmed adequate reactions in all but one patient. Considerable variations were observed in the lymphocyte stimulations tests. Conclusion Most patients reacted adequately to immunisation, especially against annual influenza and Streptococcus pneumoniae , reiterating the usefulness of vaccinations. The most appropriate timing for vaccination after treatment still needs to be determined. Article in Journal/Newspaper Iceland Reykjavík Reykjavík Wiley Online Library Reykjavík Acta Paediatrica 113 3 606 614 |
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Abstract Aim The survival rate after treatment for childhood leukaemia has greatly improved, but could result in protracted immune deficiency. This study examined the immune status of children after chemotherapy and evaluated their responses to immunisation. Methods Subjects who had completed their treatment for acute lymphoblastic leukaemia at The Children's Hospital Reykjavík, Iceland, during 2011–2020 had blood drawn and were then immunised for influenza in October 2021. Blood was drawn again 4 weeks later and their humoral and cellular responses were measured with a haemagglutination inhibition assay and lymphocyte stimulation test. Antibodies to other immunisations were also evaluated. Results We studied 18 patients (10 male) who had completed their treatment at 3.7–20.3 years of age (mean 9.1), 11–84 months (mean 36.9) before enrolment. Conventional immunological evaluation did not reveal notable abnormalities. The responses to several childhood vaccinations, including the pneumococcal conjugate vaccination, were adequate in most patients. Humoral responses to the influenza vaccine confirmed adequate reactions in all but one patient. Considerable variations were observed in the lymphocyte stimulations tests. Conclusion Most patients reacted adequately to immunisation, especially against annual influenza and Streptococcus pneumoniae , reiterating the usefulness of vaccinations. The most appropriate timing for vaccination after treatment still needs to be determined. |
format |
Article in Journal/Newspaper |
author |
Óskarsson, Ýmir Thors, Valtýr Vias, Rafael Daníel Lúðvíksson, Björn Rúnar Brynjólfsson, Siggeir Fannar Gianchecchi, Elena Razzano, Ilaria Montomoli, Emanuele Gísli Jónsson, Ólafur Haraldsson, Ásgeir |
spellingShingle |
Óskarsson, Ýmir Thors, Valtýr Vias, Rafael Daníel Lúðvíksson, Björn Rúnar Brynjólfsson, Siggeir Fannar Gianchecchi, Elena Razzano, Ilaria Montomoli, Emanuele Gísli Jónsson, Ólafur Haraldsson, Ásgeir Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
author_facet |
Óskarsson, Ýmir Thors, Valtýr Vias, Rafael Daníel Lúðvíksson, Björn Rúnar Brynjólfsson, Siggeir Fannar Gianchecchi, Elena Razzano, Ilaria Montomoli, Emanuele Gísli Jónsson, Ólafur Haraldsson, Ásgeir |
author_sort |
Óskarsson, Ýmir |
title |
Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
title_short |
Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
title_full |
Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
title_fullStr |
Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
title_full_unstemmed |
Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
title_sort |
adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1111/apa.17070 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.17070 |
geographic |
Reykjavík |
geographic_facet |
Reykjavík |
genre |
Iceland Reykjavík Reykjavík |
genre_facet |
Iceland Reykjavík Reykjavík |
op_source |
Acta Paediatrica volume 113, issue 3, page 606-614 ISSN 0803-5253 1651-2227 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/apa.17070 |
container_title |
Acta Paediatrica |
container_volume |
113 |
container_issue |
3 |
container_start_page |
606 |
op_container_end_page |
614 |
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1800755043891150848 |