Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region
Abstract Aim Vaccine‐preventable pathogens causing severe childhood infections include Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis . In this study conducted in a Swedish Arctic region, we evaluated the effects of general infant Hib and pneumococcal vaccin...
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crwiley:10.1111/apa.14824 2024-06-02T08:01:25+00:00 Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region Johansson Kostenniemi, Urban Norman, David Sellin, Mats Silfverdal, Sven‐Arne Västerbotten Läns Landsting 2019 http://dx.doi.org/10.1111/apa.14824 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapa.14824 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.14824 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/apa.14824 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Paediatrica volume 108, issue 10, page 1871-1878 ISSN 0803-5253 1651-2227 journal-article 2019 crwiley https://doi.org/10.1111/apa.14824 2024-05-03T11:47:18Z Abstract Aim Vaccine‐preventable pathogens causing severe childhood infections include Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis . In this study conducted in a Swedish Arctic region, we evaluated the effects of general infant Hib and pneumococcal vaccination on invasive infectious diseases among children and assessed the need of meningococcal vaccination. Methods We identified cases of bacterial meningitis and sepsis from diagnosis and laboratory registers in the Västerbotten Region, Sweden, during 1986–2015. We then reviewed medical records to confirm the diagnosis and extract data for assessing incidence changes, using an exploratory data analysis and a time‐series analysis. Results Invasive Haemophilus disease declined by 89.1% (p < 0.01), Haemophilus meningitis by 95.3% (p < 0.01) and all‐cause bacterial meningitis by 82.3% (p < 0.01) in children aged 0 to four years following general infant Hib vaccination. Following pneumococcal vaccination, invasive pneumococcal disease declined by 84.7% (p < 0.01), pneumococcal meningitis by 67.5% (p = 0.16) and all‐cause bacterial meningitis by 48.0% (p = 0.23). Incidence of invasive meningococcal disease remained low during the study period. Conclusion Remarkable sustained long‐term declines of invasive infectious diseases in younger children occurred following infant Hib and pneumococcal vaccinations in this Swedish Arctic region. Despite not offering general infant meningococcal vaccination, incidence of invasive meningococcal disease remained low. Article in Journal/Newspaper Arctic Wiley Online Library Arctic Acta Paediatrica 108 10 1871 1878 |
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Abstract Aim Vaccine‐preventable pathogens causing severe childhood infections include Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis . In this study conducted in a Swedish Arctic region, we evaluated the effects of general infant Hib and pneumococcal vaccination on invasive infectious diseases among children and assessed the need of meningococcal vaccination. Methods We identified cases of bacterial meningitis and sepsis from diagnosis and laboratory registers in the Västerbotten Region, Sweden, during 1986–2015. We then reviewed medical records to confirm the diagnosis and extract data for assessing incidence changes, using an exploratory data analysis and a time‐series analysis. Results Invasive Haemophilus disease declined by 89.1% (p < 0.01), Haemophilus meningitis by 95.3% (p < 0.01) and all‐cause bacterial meningitis by 82.3% (p < 0.01) in children aged 0 to four years following general infant Hib vaccination. Following pneumococcal vaccination, invasive pneumococcal disease declined by 84.7% (p < 0.01), pneumococcal meningitis by 67.5% (p = 0.16) and all‐cause bacterial meningitis by 48.0% (p = 0.23). Incidence of invasive meningococcal disease remained low during the study period. Conclusion Remarkable sustained long‐term declines of invasive infectious diseases in younger children occurred following infant Hib and pneumococcal vaccinations in this Swedish Arctic region. Despite not offering general infant meningococcal vaccination, incidence of invasive meningococcal disease remained low. |
author2 |
Västerbotten Läns Landsting |
format |
Article in Journal/Newspaper |
author |
Johansson Kostenniemi, Urban Norman, David Sellin, Mats Silfverdal, Sven‐Arne |
spellingShingle |
Johansson Kostenniemi, Urban Norman, David Sellin, Mats Silfverdal, Sven‐Arne Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region |
author_facet |
Johansson Kostenniemi, Urban Norman, David Sellin, Mats Silfverdal, Sven‐Arne |
author_sort |
Johansson Kostenniemi, Urban |
title |
Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region |
title_short |
Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region |
title_full |
Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region |
title_fullStr |
Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region |
title_full_unstemmed |
Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region |
title_sort |
sustained reductions of invasive infectious disease following general infant haemophilus influenzae type b and pneumococcal vaccination in a swedish arctic region |
publisher |
Wiley |
publishDate |
2019 |
url |
http://dx.doi.org/10.1111/apa.14824 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapa.14824 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.14824 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/apa.14824 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Acta Paediatrica volume 108, issue 10, page 1871-1878 ISSN 0803-5253 1651-2227 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/apa.14824 |
container_title |
Acta Paediatrica |
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108 |
container_issue |
10 |
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1871 |
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1878 |
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1800745780742455296 |