Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children
Abstract Aim A well‐documented, clinically proven per rectum treatment for childhood constipation is needed. This phase two clinical trial evaluated the efficacy of suppositories containing free fatty acids ( FFA ) compared with Klyx docusate sodium and sorbitol enemas. Methods A randomised, control...
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crwiley:10.1111/apa.13394 2024-06-02T08:09:21+00:00 Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children Ormarsson, Orri Thor Asgrimsdottir, Gudrun Marta Loftsson, Thorsteinn Stefansson, Einar Lund, Sigrun Helga Bjornsson, Einar Stefan Technology Development Fund of Iceland 2016 http://dx.doi.org/10.1111/apa.13394 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapa.13394 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.13394 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Paediatrica volume 105, issue 6, page 689-694 ISSN 0803-5253 1651-2227 journal-article 2016 crwiley https://doi.org/10.1111/apa.13394 2024-05-03T10:55:36Z Abstract Aim A well‐documented, clinically proven per rectum treatment for childhood constipation is needed. This phase two clinical trial evaluated the efficacy of suppositories containing free fatty acids ( FFA ) compared with Klyx docusate sodium and sorbitol enemas. Methods A randomised, controlled, single‐blind study was undertaken on 77 children aged between one and 17 who presented to an emergency department in Iceland and were diagnosed with constipation. In stage one, 23 patients were randomised to receive lower dose FFA suppositories or Klyx (n = 33). In stage two, 21 different patients were randomised to receive higher dose suppositories and compared with the same Klyx control subjects. Results The suppositories were effective at bowel emptying in 39% of the group who received the lower FFA doses and 81% of the group receiving higher doses, compared with 88% in the Klyx control group. Symptom relief was obtained in 30% of the group receiving the lower doses and 71% of the group receiving the higher doses, compared with 73% in the control group. Conclusion The higher dose FFA suppositories were as effective as the Klyx enemas with regard to bowel emptying and symptom relief and might provide an important and less invasive alternative for childhood constipation. Article in Journal/Newspaper Iceland Wiley Online Library Acta Paediatrica 105 6 689 694 |
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Wiley Online Library |
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Abstract Aim A well‐documented, clinically proven per rectum treatment for childhood constipation is needed. This phase two clinical trial evaluated the efficacy of suppositories containing free fatty acids ( FFA ) compared with Klyx docusate sodium and sorbitol enemas. Methods A randomised, controlled, single‐blind study was undertaken on 77 children aged between one and 17 who presented to an emergency department in Iceland and were diagnosed with constipation. In stage one, 23 patients were randomised to receive lower dose FFA suppositories or Klyx (n = 33). In stage two, 21 different patients were randomised to receive higher dose suppositories and compared with the same Klyx control subjects. Results The suppositories were effective at bowel emptying in 39% of the group who received the lower FFA doses and 81% of the group receiving higher doses, compared with 88% in the Klyx control group. Symptom relief was obtained in 30% of the group receiving the lower doses and 71% of the group receiving the higher doses, compared with 73% in the control group. Conclusion The higher dose FFA suppositories were as effective as the Klyx enemas with regard to bowel emptying and symptom relief and might provide an important and less invasive alternative for childhood constipation. |
author2 |
Technology Development Fund of Iceland |
format |
Article in Journal/Newspaper |
author |
Ormarsson, Orri Thor Asgrimsdottir, Gudrun Marta Loftsson, Thorsteinn Stefansson, Einar Lund, Sigrun Helga Bjornsson, Einar Stefan |
spellingShingle |
Ormarsson, Orri Thor Asgrimsdottir, Gudrun Marta Loftsson, Thorsteinn Stefansson, Einar Lund, Sigrun Helga Bjornsson, Einar Stefan Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
author_facet |
Ormarsson, Orri Thor Asgrimsdottir, Gudrun Marta Loftsson, Thorsteinn Stefansson, Einar Lund, Sigrun Helga Bjornsson, Einar Stefan |
author_sort |
Ormarsson, Orri Thor |
title |
Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
title_short |
Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
title_full |
Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
title_fullStr |
Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
title_full_unstemmed |
Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
title_sort |
free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/apa.13394 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapa.13394 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.13394 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Acta Paediatrica volume 105, issue 6, page 689-694 ISSN 0803-5253 1651-2227 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/apa.13394 |
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Acta Paediatrica |
container_volume |
105 |
container_issue |
6 |
container_start_page |
689 |
op_container_end_page |
694 |
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1800755047311605760 |