Retinal oxygen saturation is associated with HbA1c but not with short‐term diabetes control, internal environment, smoking and mild retinopathy ‐ ROXINEGLYD study

• Published in: Acta Ophthalmologica
• Main Authors: Mlčák, Petr, Chlup, Rudolf, Kudlová, Pavla, Krystyník, Ondřej, Král, Michal, Kučerová, Veronika, Spurná, Jaromíra, Titzová, Simona, Hübnerová, Petra, Vláčil, Ondřej, Šínová, Irena, Karhanová, Marta, Zapletalová, Jana, Šín, Martin
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2021
• Subjects: Iceland
• Online Access: http://dx.doi.org/10.1111/aos.14853; https://onlinelibrary.wiley.com/doi/pdf/10.1111/aos.14853; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aos.14853

Abstract Purpose Purpose of this prospective uncontrolled single‐centre pilot study was to find an association of retinal oxygen saturation (SatO 2 ) with acid–base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions. Methods Forty‐one adults (17 men) with type 1 (N = 14) or type 2 (N = 27) diabetes mellitus, age 48.6 ± 13.5 years, diabetes duration 9 (0.1–36) years, BMI 29.4 ± 6.3 kg/m 2 , and HbA1c 52 ± 12.7 mmol/mol completed the study. The 4‐day study comprised two visits (Day l, Day 4) including 72 hr of continuous glucose monitoring (CGM) by iPro ® 2 Professional CGM (Medtronic, MiniMed, Inc., Northridge, CA, USA). Retinal oximeter Oxymap T1 (Oxymap ehf., Reykjavik, Iceland) was used to assess SatO 2 . Results Wilcoxon signed‐rank test showed no SatO 2 difference between eyes and visits. Spearman's correlation analysis revealed a significant correlation between arterial SatO 2 and PG variability in type 2 diabetes mellitus, a positive correlation of venous SatO 2 with HbA1c and with finger pulse oximetry. However, no correlation of SatO 2 with ABB, carboxyhaemoglobin, current PG, mean PG over the 72 hr, age, diabetes duration, BMI, lipoproteinaemia, body temperature, systolic and diastolic blood pressure, heart rate, central retinal thickness and retinal nerve fibre layer thickness was found. Conclusion This study confirmed the association of venous SatO 2 with long‐term but not with short‐term diabetes control, ABB and other conditions. The increased SatO 2 and questionable impact of PG variability on retinal SatO 2 is a research challenge.