Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008)
Abstract Purpose To provide sex‐stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods Population‐based study including 2617 women and 1891 men, aged 38–87 (mean 61 ± 8) years, without diabetes, glaucoma and retinal diseases, and spheri...
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crwiley:10.1111/aos.13337 2024-06-23T07:57:15+00:00 Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) von Hanno, Therese Lade, Anette C. Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir The North Norway Regional Health Authority 2016 http://dx.doi.org/10.1111/aos.13337 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faos.13337 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aos.13337 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Acta Ophthalmologica volume 95, issue 3, page 262-269 ISSN 1755-375X 1755-3768 journal-article 2016 crwiley https://doi.org/10.1111/aos.13337 2024-06-13T04:21:55Z Abstract Purpose To provide sex‐stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods Population‐based study including 2617 women and 1891 men, aged 38–87 (mean 61 ± 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction ( SER ) within ±6 dioptres. Retinal thickness was measured with optical coherence tomography (spectral domain Cirrus HD ‐ OCT ). Results Women had thinner retina than men. Retinal thickness was significantly associated with refraction, where mean change in retinal thickness per 1 D increase in SER was −1.3 (0.2) μ m in the fovea, 0.7 (0.1) μ m in the pericentral ring and 1.4 (0.1) μ m in the peripheral ring. In the fovea, there was a non‐monotonic curved relationship between retinal thickness and age in both sexes with a maximum at about 60 years (p < 0.001). In the pericentral ring, the mean reduction in retinal thickness per 10‐year increase was 2.7 (0.3) μ m in women and 4.0 (0.4) μ m in men and corresponding results in the peripheral ring were 2.3 (0.3) μ m in women and 2.6 (0.4) μ m in men. In both regions, there was evidence for a nonlinear pattern with an increased rate of change with higher age. There was a significant interaction between sex and age for retinal thickness of the pericentral ring (p = 0.041). Conclusion Women had thinner retina than men, and thickness varied with refractive status. Retinal thickness was associated with age in all macular regions, and the rate of change in retinal thickness varied at different ages. Article in Journal/Newspaper Tromsø Wiley Online Library Tromsø Acta Ophthalmologica 95 3 262 269 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract Purpose To provide sex‐stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods Population‐based study including 2617 women and 1891 men, aged 38–87 (mean 61 ± 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction ( SER ) within ±6 dioptres. Retinal thickness was measured with optical coherence tomography (spectral domain Cirrus HD ‐ OCT ). Results Women had thinner retina than men. Retinal thickness was significantly associated with refraction, where mean change in retinal thickness per 1 D increase in SER was −1.3 (0.2) μ m in the fovea, 0.7 (0.1) μ m in the pericentral ring and 1.4 (0.1) μ m in the peripheral ring. In the fovea, there was a non‐monotonic curved relationship between retinal thickness and age in both sexes with a maximum at about 60 years (p < 0.001). In the pericentral ring, the mean reduction in retinal thickness per 10‐year increase was 2.7 (0.3) μ m in women and 4.0 (0.4) μ m in men and corresponding results in the peripheral ring were 2.3 (0.3) μ m in women and 2.6 (0.4) μ m in men. In both regions, there was evidence for a nonlinear pattern with an increased rate of change with higher age. There was a significant interaction between sex and age for retinal thickness of the pericentral ring (p = 0.041). Conclusion Women had thinner retina than men, and thickness varied with refractive status. Retinal thickness was associated with age in all macular regions, and the rate of change in retinal thickness varied at different ages. |
author2 |
The North Norway Regional Health Authority |
format |
Article in Journal/Newspaper |
author |
von Hanno, Therese Lade, Anette C. Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir |
spellingShingle |
von Hanno, Therese Lade, Anette C. Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) |
author_facet |
von Hanno, Therese Lade, Anette C. Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir |
author_sort |
von Hanno, Therese |
title |
Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) |
title_short |
Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) |
title_full |
Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) |
title_fullStr |
Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) |
title_full_unstemmed |
Macular thickness in healthy eyes of adults ( N = 4508) and relation to sex, age and refraction: the Tromsø Eye Study (2007–2008) |
title_sort |
macular thickness in healthy eyes of adults ( n = 4508) and relation to sex, age and refraction: the tromsø eye study (2007–2008) |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/aos.13337 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faos.13337 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aos.13337 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Acta Ophthalmologica volume 95, issue 3, page 262-269 ISSN 1755-375X 1755-3768 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1111/aos.13337 |
container_title |
Acta Ophthalmologica |
container_volume |
95 |
container_issue |
3 |
container_start_page |
262 |
op_container_end_page |
269 |
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1802650788158242816 |