Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study
Abstract Purpose To examine associations between cardiovascular risk factors and age‐related macular degeneration ( AMD ). Methods A population‐based, cross‐sectional study of C aucasians aged 65–87 years was conducted in N orway in 2007/2008. Retinal photographs were graded for AMD . Multivariable...
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crwiley:10.1111/aos.12346 2024-09-15T18:39:28+00:00 Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger Northern Norway Regional Health Moorfields Eye Hospital NHS Foundation Trust UCL Institute of Ophthalmology, London, UK 2014 http://dx.doi.org/10.1111/aos.12346 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faos.12346 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aos.12346 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Ophthalmologica volume 92, issue 7, page 662-669 ISSN 1755-375X 1755-3768 journal-article 2014 crwiley https://doi.org/10.1111/aos.12346 2024-08-27T04:29:17Z Abstract Purpose To examine associations between cardiovascular risk factors and age‐related macular degeneration ( AMD ). Methods A population‐based, cross‐sectional study of C aucasians aged 65–87 years was conducted in N orway in 2007/2008. Retinal photographs were graded for AMD . Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end‐point registry. Results Gradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD . In the multivariable analysis of late AMD , significant interactions were found between sex and the variables age, triglyceride level, use of lipid‐lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio ( OR ) 4.06, 95% confidence interval ( CI ) 1.69–9.76 and OR 3.59, 95% CI 1.17–11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125 μ m) ( OR 1.04, 95% CI 1.01–1.09 per 5 years). Higher systolic blood pressure ( OR 1.06, 95% CI 1.01–1.12 per 5 mmHg), overweight ( OR 2.87, 95% CI 1.13–7.29) and obesity ( OR 2.92, 95% CI 1.06–8.03), physical exercise duration ( OR 0.41, 95% 0.18–0.96 for 30 min or more compared with less) and frequency ( OR 0.46, 95% CI 0.23–0.92 for weekly or more often compared to less) were associated with late AMD in women only. Conclusions Smoking was strongly associated with AMD , in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women. Article in Journal/Newspaper Tromsø Wiley Online Library Acta Ophthalmologica 92 7 662 669 |
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Wiley Online Library |
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English |
description |
Abstract Purpose To examine associations between cardiovascular risk factors and age‐related macular degeneration ( AMD ). Methods A population‐based, cross‐sectional study of C aucasians aged 65–87 years was conducted in N orway in 2007/2008. Retinal photographs were graded for AMD . Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end‐point registry. Results Gradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD . In the multivariable analysis of late AMD , significant interactions were found between sex and the variables age, triglyceride level, use of lipid‐lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio ( OR ) 4.06, 95% confidence interval ( CI ) 1.69–9.76 and OR 3.59, 95% CI 1.17–11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125 μ m) ( OR 1.04, 95% CI 1.01–1.09 per 5 years). Higher systolic blood pressure ( OR 1.06, 95% CI 1.01–1.12 per 5 mmHg), overweight ( OR 2.87, 95% CI 1.13–7.29) and obesity ( OR 2.92, 95% CI 1.06–8.03), physical exercise duration ( OR 0.41, 95% 0.18–0.96 for 30 min or more compared with less) and frequency ( OR 0.46, 95% CI 0.23–0.92 for weekly or more often compared to less) were associated with late AMD in women only. Conclusions Smoking was strongly associated with AMD , in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women. |
author2 |
Northern Norway Regional Health Moorfields Eye Hospital NHS Foundation Trust UCL Institute of Ophthalmology, London, UK |
format |
Article in Journal/Newspaper |
author |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger |
spellingShingle |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study |
author_facet |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger |
author_sort |
Erke, Maja G |
title |
Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study |
title_short |
Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study |
title_full |
Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study |
title_fullStr |
Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study |
title_full_unstemmed |
Cardiovascular risk factors associated with age‐related macular degeneration: the Tromsø Study |
title_sort |
cardiovascular risk factors associated with age‐related macular degeneration: the tromsø study |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1111/aos.12346 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faos.12346 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aos.12346 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Acta Ophthalmologica volume 92, issue 7, page 662-669 ISSN 1755-375X 1755-3768 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/aos.12346 |
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Acta Ophthalmologica |
container_volume |
92 |
container_issue |
7 |
container_start_page |
662 |
op_container_end_page |
669 |
_version_ |
1810483831144185856 |