Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients
Abstract Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine‐driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to th...
Published in: | Artificial Organs |
---|---|
Main Authors: | , , , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2018
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/aor.13320 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faor.13320 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aor.13320 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13320 |
id |
crwiley:10.1111/aor.13320 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/aor.13320 2024-06-02T08:12:12+00:00 Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundström, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd County Council Vasterbotten Njurföreningen Västerbotten, Sweden, and Skaraborgs Hospital (FoU), Sweden 2018 http://dx.doi.org/10.1111/aor.13320 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faor.13320 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aor.13320 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13320 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Artificial Organs volume 43, issue 2, page 173-180 ISSN 0160-564X 1525-1594 journal-article 2018 crwiley https://doi.org/10.1111/aor.13320 2024-05-03T11:04:34Z Abstract Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine‐driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to the tissue accumulation of AGEs and rises with age. SAF is one of the strongest prognostic markers of mortality in these patients. The content of AGEs is high in barbecue food. Due to the location in northern Sweden, there is a short intense barbecue season between June and August. The aim of this study was to investigate if seasonal variations in SAF exist in HD patients, especially during the barbecue season. SAF was measured noninvasively with an AGE Reader in 34 HD‐patients (15 of those with diabetes mellitus, DM). Each time the median of three measures were used. Skin‐AF was measured before and after each one HD at the end of February and May in 31 patients (22 men/9 women); the end of May and August in 28 (20 m/8 w); the end of August and March in 25 (19 m/6 w). Paired statistical analyses were performed during all four periods ( n = 23, 17 m/6 w); as was HbA1c of those with DM. There was at a median 5.6% increase in skin‐AF during the winter period (February–May, P = 0.004) and a 10.6% decrease in the skin‐AF during the summer (May–August, P < 0.001). HbA1c in the DM rose during the summer ( P = 0.013). In conclusion, skin‐AF decreased significantly during the summer. Future studies should look for favorable factors that prevent skin‐AF and subsequently cardiovascular diseases. Article in Journal/Newspaper Northern Sweden Wiley Online Library Artificial Organs 43 2 173 180 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine‐driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to the tissue accumulation of AGEs and rises with age. SAF is one of the strongest prognostic markers of mortality in these patients. The content of AGEs is high in barbecue food. Due to the location in northern Sweden, there is a short intense barbecue season between June and August. The aim of this study was to investigate if seasonal variations in SAF exist in HD patients, especially during the barbecue season. SAF was measured noninvasively with an AGE Reader in 34 HD‐patients (15 of those with diabetes mellitus, DM). Each time the median of three measures were used. Skin‐AF was measured before and after each one HD at the end of February and May in 31 patients (22 men/9 women); the end of May and August in 28 (20 m/8 w); the end of August and March in 25 (19 m/6 w). Paired statistical analyses were performed during all four periods ( n = 23, 17 m/6 w); as was HbA1c of those with DM. There was at a median 5.6% increase in skin‐AF during the winter period (February–May, P = 0.004) and a 10.6% decrease in the skin‐AF during the summer (May–August, P < 0.001). HbA1c in the DM rose during the summer ( P = 0.013). In conclusion, skin‐AF decreased significantly during the summer. Future studies should look for favorable factors that prevent skin‐AF and subsequently cardiovascular diseases. |
author2 |
County Council Vasterbotten Njurföreningen Västerbotten, Sweden, and Skaraborgs Hospital (FoU), Sweden |
format |
Article in Journal/Newspaper |
author |
Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundström, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd |
spellingShingle |
Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundström, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
author_facet |
Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundström, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd |
author_sort |
Ramsauer, Bernd |
title |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_short |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_full |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_fullStr |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_full_unstemmed |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_sort |
skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, decreases during the summer in dialysis patients |
publisher |
Wiley |
publishDate |
2018 |
url |
http://dx.doi.org/10.1111/aor.13320 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Faor.13320 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aor.13320 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aor.13320 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Artificial Organs volume 43, issue 2, page 173-180 ISSN 0160-564X 1525-1594 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/aor.13320 |
container_title |
Artificial Organs |
container_volume |
43 |
container_issue |
2 |
container_start_page |
173 |
op_container_end_page |
180 |
_version_ |
1800758578111315968 |