Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study
Abstract Introduction This population‐based follow‐up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. Material and methods The study population derived from the Northern Finland Birth Cohort 1966 and con...
Published in: | Acta Obstetricia et Gynecologica Scandinavica |
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Online Access: | http://dx.doi.org/10.1111/aogs.14382 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aogs.14382 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aogs.14382 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/aogs.14382 |
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crwiley:10.1111/aogs.14382 2024-09-30T14:40:07+00:00 Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. Jalmari ja Rauha Ahokkaan Säätiö Päivikki ja Sakari Sohlbergin Säätiö Pohjois-Pohjanmaan Rahasto Sigrid Juséliuksen Säätiö Suomen Lääketieteen Säätiö European Regional Development Fund Socialdepartementet Oulun Yliopisto Medical Research Council Canada Genesis Research Trust Päivikki ja Sakari Sohlbergin Säätiö Jalmari ja Rauha Ahokkaan Säätiö Suomen Kulttuurirahasto Academy of Finland Suomen Lääketieteen Säätiö 2022 http://dx.doi.org/10.1111/aogs.14382 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aogs.14382 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aogs.14382 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/aogs.14382 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Acta Obstetricia et Gynecologica Scandinavica volume 101, issue 7, page 728-736 ISSN 0001-6349 1600-0412 journal-article 2022 crwiley https://doi.org/10.1111/aogs.14382 2024-09-17T04:43:24Z Abstract Introduction This population‐based follow‐up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. Material and methods The study population derived from the Northern Finland Birth Cohort 1966 and consisted of women reporting oligo/amenorrhea and hirsutism at age 31 years and/or a PCOS diagnosis by age 46 years ( n = 246) and controls without PCOS symptoms or diagnosis ( n = 1573), referred to as non‐PCOS women. The main outcome measures were self‐reported data on symptoms, diagnosed diseases, and medication and healthcare service use at the age of 46 years. Results Overall morbidity risk was increased by 35% (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.16–1.57) and medication use by 27% [RR 1.27, 95% CI 1.08–1.50) compared with non‐PCOS women, and the risk remained after adjusting for body mass index. Diagnoses with increased prevalence in women with PCOS were migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis. PCOS was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, healthcare service use did not differ between the study groups after adjusting for body mass index. Conclusions Women with PCOS are burdened with multimorbidity and higher medication use, independent of body mass index. Article in Journal/Newspaper Northern Finland Wiley Online Library Acta Obstetricia et Gynecologica Scandinavica 101 7 728 736 |
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English |
description |
Abstract Introduction This population‐based follow‐up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. Material and methods The study population derived from the Northern Finland Birth Cohort 1966 and consisted of women reporting oligo/amenorrhea and hirsutism at age 31 years and/or a PCOS diagnosis by age 46 years ( n = 246) and controls without PCOS symptoms or diagnosis ( n = 1573), referred to as non‐PCOS women. The main outcome measures were self‐reported data on symptoms, diagnosed diseases, and medication and healthcare service use at the age of 46 years. Results Overall morbidity risk was increased by 35% (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.16–1.57) and medication use by 27% [RR 1.27, 95% CI 1.08–1.50) compared with non‐PCOS women, and the risk remained after adjusting for body mass index. Diagnoses with increased prevalence in women with PCOS were migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis. PCOS was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, healthcare service use did not differ between the study groups after adjusting for body mass index. Conclusions Women with PCOS are burdened with multimorbidity and higher medication use, independent of body mass index. |
author2 |
Jalmari ja Rauha Ahokkaan Säätiö Päivikki ja Sakari Sohlbergin Säätiö Pohjois-Pohjanmaan Rahasto Sigrid Juséliuksen Säätiö Suomen Lääketieteen Säätiö European Regional Development Fund Socialdepartementet Oulun Yliopisto Medical Research Council Canada Genesis Research Trust Päivikki ja Sakari Sohlbergin Säätiö Jalmari ja Rauha Ahokkaan Säätiö Suomen Kulttuurirahasto Academy of Finland Suomen Lääketieteen Säätiö |
format |
Article in Journal/Newspaper |
author |
Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. |
spellingShingle |
Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
author_facet |
Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. |
author_sort |
Kujanpää, Linda |
title |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_short |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_full |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_fullStr |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_full_unstemmed |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_sort |
women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: a population‐based cohort study |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1111/aogs.14382 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aogs.14382 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aogs.14382 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/aogs.14382 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Acta Obstetricia et Gynecologica Scandinavica volume 101, issue 7, page 728-736 ISSN 0001-6349 1600-0412 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1111/aogs.14382 |
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Acta Obstetricia et Gynecologica Scandinavica |
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101 |
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7 |
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728 |
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736 |
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1811642651817017344 |