High incidence and persistence of airborne allergen sensitization up to age 19 years
Abstract Background Longitudinal population‐based studies about the natural history of allergic sensitization are rare. The aim was to study incidence and persistence of airborne allergen sensitization up to young adulthood and risk factors for early and late onset of sensitization. Methods All chil...
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crwiley:10.1111/all.13053 2024-09-15T18:26:12+00:00 High incidence and persistence of airborne allergen sensitization up to age 19 years Rönmark, E. Warm, K. Bjerg, A. Backman, H. Hedman, L. Lundbäck, B. Hjärt-Lungfonden Vetenskapsrådet Vårdalstiftelsen 2016 http://dx.doi.org/10.1111/all.13053 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fall.13053 https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.13053 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Allergy volume 72, issue 5, page 723-730 ISSN 0105-4538 1398-9995 journal-article 2016 crwiley https://doi.org/10.1111/all.13053 2024-07-30T04:23:25Z Abstract Background Longitudinal population‐based studies about the natural history of allergic sensitization are rare. The aim was to study incidence and persistence of airborne allergen sensitization up to young adulthood and risk factors for early and late onset of sensitization. Methods All children aged 7–8 years in two municipalities in Northern Sweden were invited to a parental questionnaire and skin prick tests (SPTs) to ten airborne allergens, and 2148 (88%) participated. The protocol was repeated at age 11–12 and 19 years, and 1516 participated in all three examinations. Results Prevalence of any positive SPT increased from 20.6% at age 7–8 years to 30.6% at 11–12 years, and 42.1% at 19 years. Animals were the primary sensitizers at age 7–8 years, 16.3%, followed by pollen, 12.4%. Mite and mold sensitization was low. Mean annual incidence of any positive SPT varied between 2.8 and 3.4/100 per year, decreased by age for animal, and was stable for pollen. Sensitization before age 7–8 years was independently associated with family history of allergy, OR 2.1 (95% CI 1.6–2.8), urban living, OR 1.9 (95% CI 1.2–2.9), and male sex, OR 1.3 (95% CI 1.0–1.7), and negatively associated with birth order, OR 0.8 (95% CI 0.7–1.0), and furry animals at home, OR 0.7 (95% CI 0.7–0.9). Incidence after age 11–12 years was associated only with family history of allergy. Multisensitization at age 19 years was significantly associated with early age at sensitization. Remission of sensitization was uncommon. Conclusion The increasing prevalence of allergic sensitization by age was explained by high incidence and persistence. After age 11–12 years, the factors urban living, number of siblings, and male sex lost their importance. Article in Journal/Newspaper Northern Sweden Mite Wiley Online Library Allergy 72 5 723 730 |
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Abstract Background Longitudinal population‐based studies about the natural history of allergic sensitization are rare. The aim was to study incidence and persistence of airborne allergen sensitization up to young adulthood and risk factors for early and late onset of sensitization. Methods All children aged 7–8 years in two municipalities in Northern Sweden were invited to a parental questionnaire and skin prick tests (SPTs) to ten airborne allergens, and 2148 (88%) participated. The protocol was repeated at age 11–12 and 19 years, and 1516 participated in all three examinations. Results Prevalence of any positive SPT increased from 20.6% at age 7–8 years to 30.6% at 11–12 years, and 42.1% at 19 years. Animals were the primary sensitizers at age 7–8 years, 16.3%, followed by pollen, 12.4%. Mite and mold sensitization was low. Mean annual incidence of any positive SPT varied between 2.8 and 3.4/100 per year, decreased by age for animal, and was stable for pollen. Sensitization before age 7–8 years was independently associated with family history of allergy, OR 2.1 (95% CI 1.6–2.8), urban living, OR 1.9 (95% CI 1.2–2.9), and male sex, OR 1.3 (95% CI 1.0–1.7), and negatively associated with birth order, OR 0.8 (95% CI 0.7–1.0), and furry animals at home, OR 0.7 (95% CI 0.7–0.9). Incidence after age 11–12 years was associated only with family history of allergy. Multisensitization at age 19 years was significantly associated with early age at sensitization. Remission of sensitization was uncommon. Conclusion The increasing prevalence of allergic sensitization by age was explained by high incidence and persistence. After age 11–12 years, the factors urban living, number of siblings, and male sex lost their importance. |
author2 |
Hjärt-Lungfonden Vetenskapsrådet Vårdalstiftelsen |
format |
Article in Journal/Newspaper |
author |
Rönmark, E. Warm, K. Bjerg, A. Backman, H. Hedman, L. Lundbäck, B. |
spellingShingle |
Rönmark, E. Warm, K. Bjerg, A. Backman, H. Hedman, L. Lundbäck, B. High incidence and persistence of airborne allergen sensitization up to age 19 years |
author_facet |
Rönmark, E. Warm, K. Bjerg, A. Backman, H. Hedman, L. Lundbäck, B. |
author_sort |
Rönmark, E. |
title |
High incidence and persistence of airborne allergen sensitization up to age 19 years |
title_short |
High incidence and persistence of airborne allergen sensitization up to age 19 years |
title_full |
High incidence and persistence of airborne allergen sensitization up to age 19 years |
title_fullStr |
High incidence and persistence of airborne allergen sensitization up to age 19 years |
title_full_unstemmed |
High incidence and persistence of airborne allergen sensitization up to age 19 years |
title_sort |
high incidence and persistence of airborne allergen sensitization up to age 19 years |
publisher |
Wiley |
publishDate |
2016 |
url |
http://dx.doi.org/10.1111/all.13053 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fall.13053 https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.13053 |
genre |
Northern Sweden Mite |
genre_facet |
Northern Sweden Mite |
op_source |
Allergy volume 72, issue 5, page 723-730 ISSN 0105-4538 1398-9995 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/all.13053 |
container_title |
Allergy |
container_volume |
72 |
container_issue |
5 |
container_start_page |
723 |
op_container_end_page |
730 |
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1810466655242813440 |