Characteristics and predictors of off‐label use of antipsychotics in general population sample
Abstract Objective Increasing number of people have been prescribed antipsychotics (APs) off‐label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off‐label. Methods The study sample was part of the Northern Finland Birth...
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crwiley:10.1111/acps.13472 2024-09-09T19:59:21+00:00 Characteristics and predictors of off‐label use of antipsychotics in general population sample Pirhonen, Eero Haapea, Marianne Rautio, Nina Nordström, Tanja Turpeinen, Miia Laatikainen, Outi Koponen, Hannu Silvan, Jenni Miettunen, Jouko Jääskeläinen, Erika Academy of Finland 2022 http://dx.doi.org/10.1111/acps.13472 https://onlinelibrary.wiley.com/doi/pdf/10.1111/acps.13472 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acps.13472 en eng Wiley http://creativecommons.org/licenses/by-nc/4.0/ Acta Psychiatrica Scandinavica volume 146, issue 3, page 227-239 ISSN 0001-690X 1600-0447 journal-article 2022 crwiley https://doi.org/10.1111/acps.13472 2024-08-01T04:23:38Z Abstract Objective Increasing number of people have been prescribed antipsychotics (APs) off‐label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off‐label. Methods The study sample was part of the Northern Finland Birth Cohort 1966 ( n = 7071). Data included questionnaires and national register data. Information on prescribed medications was extracted from the national register. The sample was divided into three groups: Persons who had been prescribed APs off‐label ( n = 137), individuals with non‐psychotic mental disorders without APs off label ( n = 1478) and individuals who had been diagnosed with psychosis or bipolar disorder and who had been prescribed APs ( n = 151). We compared sociodemographic, lifestyle and clinical characteristics between the off‐label and the comparison groups using logistic regression. Results The most common diagnoses in the off‐label group were depression ( n = 96, 70.1%) and anxiety ( n = 55, 40.1%). Compared with individuals with non‐psychotic mental disorders who were not prescribed APs off‐label, individuals with prescribed off‐label APs had a lower level of education, lower socioeconomic status, were less often married, had a higher level of somatic and psychiatric morbidity, were more often smokers and more often had a substance abuse disorder and heavy alcohol consumption. When comparing the off‐label group to individuals with psychosis or bipolar disorder who used APs, there were less differences, though individuals with psychosis or bipolar disorder had more markers of morbidity and a lower level of education. Conclusion Individuals who had been prescribed APs off label had a higher level of mental and somatic morbidity and poorer socioeconomic status than individuals with non‐psychotic mental disorders who did not use APs. Article in Journal/Newspaper Northern Finland Wiley Online Library Acta Psychiatrica Scandinavica 146 3 227 239 |
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Abstract Objective Increasing number of people have been prescribed antipsychotics (APs) off‐label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off‐label. Methods The study sample was part of the Northern Finland Birth Cohort 1966 ( n = 7071). Data included questionnaires and national register data. Information on prescribed medications was extracted from the national register. The sample was divided into three groups: Persons who had been prescribed APs off‐label ( n = 137), individuals with non‐psychotic mental disorders without APs off label ( n = 1478) and individuals who had been diagnosed with psychosis or bipolar disorder and who had been prescribed APs ( n = 151). We compared sociodemographic, lifestyle and clinical characteristics between the off‐label and the comparison groups using logistic regression. Results The most common diagnoses in the off‐label group were depression ( n = 96, 70.1%) and anxiety ( n = 55, 40.1%). Compared with individuals with non‐psychotic mental disorders who were not prescribed APs off‐label, individuals with prescribed off‐label APs had a lower level of education, lower socioeconomic status, were less often married, had a higher level of somatic and psychiatric morbidity, were more often smokers and more often had a substance abuse disorder and heavy alcohol consumption. When comparing the off‐label group to individuals with psychosis or bipolar disorder who used APs, there were less differences, though individuals with psychosis or bipolar disorder had more markers of morbidity and a lower level of education. Conclusion Individuals who had been prescribed APs off label had a higher level of mental and somatic morbidity and poorer socioeconomic status than individuals with non‐psychotic mental disorders who did not use APs. |
author2 |
Academy of Finland |
format |
Article in Journal/Newspaper |
author |
Pirhonen, Eero Haapea, Marianne Rautio, Nina Nordström, Tanja Turpeinen, Miia Laatikainen, Outi Koponen, Hannu Silvan, Jenni Miettunen, Jouko Jääskeläinen, Erika |
spellingShingle |
Pirhonen, Eero Haapea, Marianne Rautio, Nina Nordström, Tanja Turpeinen, Miia Laatikainen, Outi Koponen, Hannu Silvan, Jenni Miettunen, Jouko Jääskeläinen, Erika Characteristics and predictors of off‐label use of antipsychotics in general population sample |
author_facet |
Pirhonen, Eero Haapea, Marianne Rautio, Nina Nordström, Tanja Turpeinen, Miia Laatikainen, Outi Koponen, Hannu Silvan, Jenni Miettunen, Jouko Jääskeläinen, Erika |
author_sort |
Pirhonen, Eero |
title |
Characteristics and predictors of off‐label use of antipsychotics in general population sample |
title_short |
Characteristics and predictors of off‐label use of antipsychotics in general population sample |
title_full |
Characteristics and predictors of off‐label use of antipsychotics in general population sample |
title_fullStr |
Characteristics and predictors of off‐label use of antipsychotics in general population sample |
title_full_unstemmed |
Characteristics and predictors of off‐label use of antipsychotics in general population sample |
title_sort |
characteristics and predictors of off‐label use of antipsychotics in general population sample |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1111/acps.13472 https://onlinelibrary.wiley.com/doi/pdf/10.1111/acps.13472 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acps.13472 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Acta Psychiatrica Scandinavica volume 146, issue 3, page 227-239 ISSN 0001-690X 1600-0447 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1111/acps.13472 |
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Acta Psychiatrica Scandinavica |
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146 |
container_issue |
3 |
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227 |
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239 |
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1809930481237491712 |