Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study
Abstract Background Despite multiple studies suggesting that low 25(OH)D‐vitamin levels are associated with worse outcomes in critically ill individuals, attempts to mitigate the outcomes by fixed dose enteral supplementation unguided by baseline or target blood levels have been unsuccessful. Since...
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crwiley:10.1111/aas.14137 2024-09-15T18:14:37+00:00 Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study Jonsdottir, Gudrun Maria Kvaran, Runar Bragi Skarphedinsdottir, Sigurbjorg Johanna Karason, Sigurbergur Krueger, Diane Coursin, Douglas B. Binkley, Neil Hoofnagle, Andrew N. Hogan, Kirk Sigurdsson, Gisli Heimir Sigurdsson, Martin Ingi 2022 http://dx.doi.org/10.1111/aas.14137 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aas.14137 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aas.14137 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Anaesthesiologica Scandinavica volume 66, issue 10, page 1202-1210 ISSN 0001-5172 1399-6576 journal-article 2022 crwiley https://doi.org/10.1111/aas.14137 2024-08-20T04:16:48Z Abstract Background Despite multiple studies suggesting that low 25(OH)D‐vitamin levels are associated with worse outcomes in critically ill individuals, attempts to mitigate the outcomes by fixed dose enteral supplementation unguided by baseline or target blood levels have been unsuccessful. Since a single measurement of 25(OH)D may not optimally reflect an individual's vitamin D status, we studied the plasma concentration of different vitamin D metabolites and their recovery during and following resolution of acute critical illness. Methods A prospective observational study including patients 18 years and older admitted to a mixed medical‐surgical ICU in Reykjavik, Iceland, located at a high‐northern altitude (64° N). Vitamin D metabolites were measured at three timepoints; On admission (S1), 3–5 days following admission (S2) and after recovery from acute illness (median 178 days) (S3). Concentrations of total 25(OH)D‐vitamin, cholecalciferol (D 3 ), total 24,25(OH)D‐vitamin, vitamin D binding protein (VDBP) were measured with LC‐tandem mass spectrometry (LC–MS/MS) and free 25‐(OH)D was measured with enzyme‐linked immunosorbent assay. Results Most individuals were vitamin D deficient when assessed during critical illness, with 25(OH)D‐vitamin levels under 30 ng/ml for 37/40 individuals at timepoint S1 and 34/38 at S2. After recovery, 18/30 patients were deficient at S3. Levels of all vitamin D metabolites measured were low during critical illness but rose substantially following resolution of acute illness. No strong correlation was found between markers of acute illness severity or duration and resolution of vitamin D metabolites in the interval between acute illness and recovery. Conclusions In critically ill patients, levels of multiple vitamin D metabolites are low but substantial recovery occurs following resolution of acute illness. It is unclear whether a single metabolite is sufficient to assess vitamin D status of critically ill patients and guide potential supplementation. Article in Journal/Newspaper Iceland Wiley Online Library Acta Anaesthesiologica Scandinavica 66 10 1202 1210 |
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Wiley Online Library |
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Abstract Background Despite multiple studies suggesting that low 25(OH)D‐vitamin levels are associated with worse outcomes in critically ill individuals, attempts to mitigate the outcomes by fixed dose enteral supplementation unguided by baseline or target blood levels have been unsuccessful. Since a single measurement of 25(OH)D may not optimally reflect an individual's vitamin D status, we studied the plasma concentration of different vitamin D metabolites and their recovery during and following resolution of acute critical illness. Methods A prospective observational study including patients 18 years and older admitted to a mixed medical‐surgical ICU in Reykjavik, Iceland, located at a high‐northern altitude (64° N). Vitamin D metabolites were measured at three timepoints; On admission (S1), 3–5 days following admission (S2) and after recovery from acute illness (median 178 days) (S3). Concentrations of total 25(OH)D‐vitamin, cholecalciferol (D 3 ), total 24,25(OH)D‐vitamin, vitamin D binding protein (VDBP) were measured with LC‐tandem mass spectrometry (LC–MS/MS) and free 25‐(OH)D was measured with enzyme‐linked immunosorbent assay. Results Most individuals were vitamin D deficient when assessed during critical illness, with 25(OH)D‐vitamin levels under 30 ng/ml for 37/40 individuals at timepoint S1 and 34/38 at S2. After recovery, 18/30 patients were deficient at S3. Levels of all vitamin D metabolites measured were low during critical illness but rose substantially following resolution of acute illness. No strong correlation was found between markers of acute illness severity or duration and resolution of vitamin D metabolites in the interval between acute illness and recovery. Conclusions In critically ill patients, levels of multiple vitamin D metabolites are low but substantial recovery occurs following resolution of acute illness. It is unclear whether a single metabolite is sufficient to assess vitamin D status of critically ill patients and guide potential supplementation. |
format |
Article in Journal/Newspaper |
author |
Jonsdottir, Gudrun Maria Kvaran, Runar Bragi Skarphedinsdottir, Sigurbjorg Johanna Karason, Sigurbergur Krueger, Diane Coursin, Douglas B. Binkley, Neil Hoofnagle, Andrew N. Hogan, Kirk Sigurdsson, Gisli Heimir Sigurdsson, Martin Ingi |
spellingShingle |
Jonsdottir, Gudrun Maria Kvaran, Runar Bragi Skarphedinsdottir, Sigurbjorg Johanna Karason, Sigurbergur Krueger, Diane Coursin, Douglas B. Binkley, Neil Hoofnagle, Andrew N. Hogan, Kirk Sigurdsson, Gisli Heimir Sigurdsson, Martin Ingi Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study |
author_facet |
Jonsdottir, Gudrun Maria Kvaran, Runar Bragi Skarphedinsdottir, Sigurbjorg Johanna Karason, Sigurbergur Krueger, Diane Coursin, Douglas B. Binkley, Neil Hoofnagle, Andrew N. Hogan, Kirk Sigurdsson, Gisli Heimir Sigurdsson, Martin Ingi |
author_sort |
Jonsdottir, Gudrun Maria |
title |
Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study |
title_short |
Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study |
title_full |
Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study |
title_fullStr |
Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study |
title_full_unstemmed |
Changes in vitamin D metabolites at the time of critical illness and 6 months later—A prospective observational study |
title_sort |
changes in vitamin d metabolites at the time of critical illness and 6 months later—a prospective observational study |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1111/aas.14137 https://onlinelibrary.wiley.com/doi/pdf/10.1111/aas.14137 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/aas.14137 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Acta Anaesthesiologica Scandinavica volume 66, issue 10, page 1202-1210 ISSN 0001-5172 1399-6576 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/aas.14137 |
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Acta Anaesthesiologica Scandinavica |
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66 |
container_issue |
10 |
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1202 |
op_container_end_page |
1210 |
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1810452391166738432 |