Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects
Abstract Dietary factors, particularly proteins, have been extensively explored to combat cognitive impairment. We have previously reported that dietary fish (Alaska Pollock) protein (APP) is more effective than casein (CAS) or fish oil in maintaining short‐term memory in senescence‐accelerated mice...
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Online Access: | http://dx.doi.org/10.1111/1750-3841.17119 |
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crwiley:10.1111/1750-3841.17119 2024-09-15T17:35:34+00:00 Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects Murakami, Yuki Hosomi, Ryota Murakami, Hirokazu Nishimoto, Ayano Tanaka, Genki Kimura, Takahiro Imamura, Yukio Yoshida, Munehiro Fukunaga, Kenji Toyo Suisan Foundation 2024 http://dx.doi.org/10.1111/1750-3841.17119 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Food Science volume 89, issue 6, page 3776-3787 ISSN 0022-1147 1750-3841 journal-article 2024 crwiley https://doi.org/10.1111/1750-3841.17119 2024-07-04T04:31:26Z Abstract Dietary factors, particularly proteins, have been extensively explored to combat cognitive impairment. We have previously reported that dietary fish (Alaska Pollock) protein (APP) is more effective than casein (CAS) or fish oil in maintaining short‐term memory in senescence‐accelerated mice prone 10 (SAMP10). To examine the specificity of the protective effect of APP intakes against short‐term memory decline, we assessed the impact of various dietary animal proteins, including APP, CAS, chicken breast protein (CP), and whey protein (WP), against age‐related cognitive function in SAMP10 mice. After feeding the experimental diets for 5 months, memory was assessed using the Y‐maze. The APP group exhibited a significant increase in spontaneous alternation behavior as an indicator of working memory when group compared with groups fed with other protein source. Additionally, the APP group displayed significantly higher neurofilament heavy chain positivity than the CAS and CP groups, as evidenced immunohistochemical analysis. Gut microbiota analysis indicated that dietary APP significantly enhanced the relative abundance of Lactobacillus , which positively correlated with spontaneous alternation behavior. Collectively, these findings suggest that dietary APP is more effective than CAS, CP, or WP in preventing age‐related short‐term memory decline and morphological abnormalities in the hippocampal axons of SAMP10 mice. Moreover, APP‐mediated improvements in cognitive deficits may be associated with changes in microbiota diversity. Practical Application This research suggests that dietary fish protein from Alaska Pollock may be more efficient in prevention short‐term memory decline in mice, compared to other animal proteins. This finding has practical implications for nutritional optimization, developing the new health food products, and elucidating the relationship between the impact of specific proteins on gut microbiota and prevention of age‐related cognitive decline. Article in Journal/Newspaper alaska pollock Alaska Wiley Online Library Journal of Food Science 89 6 3776 3787 |
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Wiley Online Library |
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crwiley |
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English |
description |
Abstract Dietary factors, particularly proteins, have been extensively explored to combat cognitive impairment. We have previously reported that dietary fish (Alaska Pollock) protein (APP) is more effective than casein (CAS) or fish oil in maintaining short‐term memory in senescence‐accelerated mice prone 10 (SAMP10). To examine the specificity of the protective effect of APP intakes against short‐term memory decline, we assessed the impact of various dietary animal proteins, including APP, CAS, chicken breast protein (CP), and whey protein (WP), against age‐related cognitive function in SAMP10 mice. After feeding the experimental diets for 5 months, memory was assessed using the Y‐maze. The APP group exhibited a significant increase in spontaneous alternation behavior as an indicator of working memory when group compared with groups fed with other protein source. Additionally, the APP group displayed significantly higher neurofilament heavy chain positivity than the CAS and CP groups, as evidenced immunohistochemical analysis. Gut microbiota analysis indicated that dietary APP significantly enhanced the relative abundance of Lactobacillus , which positively correlated with spontaneous alternation behavior. Collectively, these findings suggest that dietary APP is more effective than CAS, CP, or WP in preventing age‐related short‐term memory decline and morphological abnormalities in the hippocampal axons of SAMP10 mice. Moreover, APP‐mediated improvements in cognitive deficits may be associated with changes in microbiota diversity. Practical Application This research suggests that dietary fish protein from Alaska Pollock may be more efficient in prevention short‐term memory decline in mice, compared to other animal proteins. This finding has practical implications for nutritional optimization, developing the new health food products, and elucidating the relationship between the impact of specific proteins on gut microbiota and prevention of age‐related cognitive decline. |
author2 |
Toyo Suisan Foundation |
format |
Article in Journal/Newspaper |
author |
Murakami, Yuki Hosomi, Ryota Murakami, Hirokazu Nishimoto, Ayano Tanaka, Genki Kimura, Takahiro Imamura, Yukio Yoshida, Munehiro Fukunaga, Kenji |
spellingShingle |
Murakami, Yuki Hosomi, Ryota Murakami, Hirokazu Nishimoto, Ayano Tanaka, Genki Kimura, Takahiro Imamura, Yukio Yoshida, Munehiro Fukunaga, Kenji Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects |
author_facet |
Murakami, Yuki Hosomi, Ryota Murakami, Hirokazu Nishimoto, Ayano Tanaka, Genki Kimura, Takahiro Imamura, Yukio Yoshida, Munehiro Fukunaga, Kenji |
author_sort |
Murakami, Yuki |
title |
Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects |
title_short |
Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects |
title_full |
Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects |
title_fullStr |
Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects |
title_full_unstemmed |
Exploring animal protein sources against prevent age‐related short‐term memory decline in mice: Dietary fish (Alaska Pollock) protein exhibits superior protective effects |
title_sort |
exploring animal protein sources against prevent age‐related short‐term memory decline in mice: dietary fish (alaska pollock) protein exhibits superior protective effects |
publisher |
Wiley |
publishDate |
2024 |
url |
http://dx.doi.org/10.1111/1750-3841.17119 |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
Journal of Food Science volume 89, issue 6, page 3776-3787 ISSN 0022-1147 1750-3841 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/1750-3841.17119 |
container_title |
Journal of Food Science |
container_volume |
89 |
container_issue |
6 |
container_start_page |
3776 |
op_container_end_page |
3787 |
_version_ |
1810467263016337408 |