Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986
Objective To investigate the long‐term consequences of prenatal exposure to maternal hyperemesis gravidarum upon offspring cardiometabolic risk factors. Design This study is part of the prospective follow‐up of the Northern Finland Birth Cohort 1986. Setting Between 1 July 1985 and 30 June 1986 all...
Published in: | BJOG: An International Journal of Obstetrics & Gynaecology |
---|---|
Main Authors: | , , , , , , , |
Other Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2017
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/1471-0528.14534 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1471-0528.14534 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.14534 |
id |
crwiley:10.1111/1471-0528.14534 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/1471-0528.14534 2024-06-23T07:55:30+00:00 Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 Koot, MH Grooten, IJ Sebert, S Koiranen, M Järvelin, MR Kajantie, E Painter, RC Roseboom, TJ Suomen Akatemia Medical Research Council European Commission 2017 http://dx.doi.org/10.1111/1471-0528.14534 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1471-0528.14534 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.14534 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor BJOG: An International Journal of Obstetrics & Gynaecology volume 124, issue 7, page 1107-1114 ISSN 1470-0328 1471-0528 journal-article 2017 crwiley https://doi.org/10.1111/1471-0528.14534 2024-06-13T04:23:20Z Objective To investigate the long‐term consequences of prenatal exposure to maternal hyperemesis gravidarum upon offspring cardiometabolic risk factors. Design This study is part of the prospective follow‐up of the Northern Finland Birth Cohort 1986. Setting Between 1 July 1985 and 30 June 1986 all pregnant women in two provinces of Finland were recruited at first antenatal visit (99% of eligible participated). Population A total of 8953 women with liveborn singleton offspring who consented to having their children followed‐up were included. Methods Hyperemesis gravidarum ( HG ) was defined as hospitalisation during pregnancy for HG based on the International Classification of Disease ( ICD ) code. Women who were not hospitalised for HG during pregnancy were used as a reference group. Data on pregnancy and birth outcomes were obtained via medical records and questionnaires; 6462 adolescents, aged 16 years, underwent anthropometric measurements ( HG n = 42, reference n = 6420) and 5648 adolescents had a fasting blood sample taken ( HG n = 36, reference n = 5612). Main outcome measures Body mass index ( BMI ), blood pressure, fasting glucose, and lipid levels in offspring. Results Multivariate regression analyses showed no differences in offspring BMI (kg/m 2 adjusted percentage difference HG versus reference, 2.2; 95% CI −0.1, 4.6), systolic blood pressure (adjusted difference 2.1 mmHg; 95% CI −1.5, 5.6), and fasting blood glucose (mmol/l; adjusted percentage difference, 2.3; 95% CI −0.6, 5.4), between adolescents born to mothers with and without HG . Conclusions We found no evidence that prenatal exposure to HG has negative consequences for cardiometabolic health of offspring at the age of 16 years. Tweetable abstract Hyperemesis gravidarum does not affect cardiometabolic health in adolescent offspring. Article in Journal/Newspaper Northern Finland Wiley Online Library BJOG: An International Journal of Obstetrics & Gynaecology 124 7 1107 1114 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Objective To investigate the long‐term consequences of prenatal exposure to maternal hyperemesis gravidarum upon offspring cardiometabolic risk factors. Design This study is part of the prospective follow‐up of the Northern Finland Birth Cohort 1986. Setting Between 1 July 1985 and 30 June 1986 all pregnant women in two provinces of Finland were recruited at first antenatal visit (99% of eligible participated). Population A total of 8953 women with liveborn singleton offspring who consented to having their children followed‐up were included. Methods Hyperemesis gravidarum ( HG ) was defined as hospitalisation during pregnancy for HG based on the International Classification of Disease ( ICD ) code. Women who were not hospitalised for HG during pregnancy were used as a reference group. Data on pregnancy and birth outcomes were obtained via medical records and questionnaires; 6462 adolescents, aged 16 years, underwent anthropometric measurements ( HG n = 42, reference n = 6420) and 5648 adolescents had a fasting blood sample taken ( HG n = 36, reference n = 5612). Main outcome measures Body mass index ( BMI ), blood pressure, fasting glucose, and lipid levels in offspring. Results Multivariate regression analyses showed no differences in offspring BMI (kg/m 2 adjusted percentage difference HG versus reference, 2.2; 95% CI −0.1, 4.6), systolic blood pressure (adjusted difference 2.1 mmHg; 95% CI −1.5, 5.6), and fasting blood glucose (mmol/l; adjusted percentage difference, 2.3; 95% CI −0.6, 5.4), between adolescents born to mothers with and without HG . Conclusions We found no evidence that prenatal exposure to HG has negative consequences for cardiometabolic health of offspring at the age of 16 years. Tweetable abstract Hyperemesis gravidarum does not affect cardiometabolic health in adolescent offspring. |
author2 |
Suomen Akatemia Medical Research Council European Commission |
format |
Article in Journal/Newspaper |
author |
Koot, MH Grooten, IJ Sebert, S Koiranen, M Järvelin, MR Kajantie, E Painter, RC Roseboom, TJ |
spellingShingle |
Koot, MH Grooten, IJ Sebert, S Koiranen, M Järvelin, MR Kajantie, E Painter, RC Roseboom, TJ Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 |
author_facet |
Koot, MH Grooten, IJ Sebert, S Koiranen, M Järvelin, MR Kajantie, E Painter, RC Roseboom, TJ |
author_sort |
Koot, MH |
title |
Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 |
title_short |
Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 |
title_full |
Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 |
title_fullStr |
Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 |
title_full_unstemmed |
Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986 |
title_sort |
hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the northern finland birth cohort 1986 |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1111/1471-0528.14534 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1471-0528.14534 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.14534 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
BJOG: An International Journal of Obstetrics & Gynaecology volume 124, issue 7, page 1107-1114 ISSN 1470-0328 1471-0528 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/1471-0528.14534 |
container_title |
BJOG: An International Journal of Obstetrics & Gynaecology |
container_volume |
124 |
container_issue |
7 |
container_start_page |
1107 |
op_container_end_page |
1114 |
_version_ |
1802648132672028672 |