Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr
Growth performance of teleost fishes, including salmonids, is principally controlled by the growth hormone (Gh)/insulin‐like growth‐factor (Igf) axis. Igfs interact with cognate binding proteins, termed Igf binding proteins (Igfbps), which modulate the biological activities of Igfs. While Atlantic s...
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crwiley:10.1096/fasebj.31.1_supplement.719.14 2024-06-02T08:03:28+00:00 Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr Springer‐Miller, Ryan Chenoweth, Damaris Paskavitz, Amanda Regish, Amy McCormick, Stephen Breves, Jason 2017 http://dx.doi.org/10.1096/fasebj.31.1_supplement.719.14 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 31, issue S1 ISSN 0892-6638 1530-6860 journal-article 2017 crwiley https://doi.org/10.1096/fasebj.31.1_supplement.719.14 2024-05-03T10:47:37Z Growth performance of teleost fishes, including salmonids, is principally controlled by the growth hormone (Gh)/insulin‐like growth‐factor (Igf) axis. Igfs interact with cognate binding proteins, termed Igf binding proteins (Igfbps), which modulate the biological activities of Igfs. While Atlantic salmon ( Salmo salar ) are known to express an expansive set of igfbp transcripts in several key metabolic tissues, the actual regulators of igfbp expression have not been identified. Given the well‐documented consequences of mounting a glucocorticoid stress response on growth, we hypothesized that cortisol inhibits anabolic processes by directing the dynamic expression of igfbps . We therefore examined changes in the activities of the Gh/Igf/Igfbp network of salmon parr implanted with cortisol (0, 10 and 40 μg/g body weight) and sampled after 3 or 14 days. We observed reductions in body mass and fork length following 3‐ and 14‐day treatments with cortisol at 40 μg/g. A dose dependent reduction in growth rate occurred by 14 days of treatment with cortisol, whereas hepatosomatic index was not affected. We will report igfbp transcript levels in liver, skeletal muscle and gill with an aim to resolve how activities within the Igfbp network are modulated by cortisol in juvenile Atlantic salmon. Support or Funding Information Supported by Start‐Up funds to J.P.B. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library The FASEB Journal 31 S1 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Growth performance of teleost fishes, including salmonids, is principally controlled by the growth hormone (Gh)/insulin‐like growth‐factor (Igf) axis. Igfs interact with cognate binding proteins, termed Igf binding proteins (Igfbps), which modulate the biological activities of Igfs. While Atlantic salmon ( Salmo salar ) are known to express an expansive set of igfbp transcripts in several key metabolic tissues, the actual regulators of igfbp expression have not been identified. Given the well‐documented consequences of mounting a glucocorticoid stress response on growth, we hypothesized that cortisol inhibits anabolic processes by directing the dynamic expression of igfbps . We therefore examined changes in the activities of the Gh/Igf/Igfbp network of salmon parr implanted with cortisol (0, 10 and 40 μg/g body weight) and sampled after 3 or 14 days. We observed reductions in body mass and fork length following 3‐ and 14‐day treatments with cortisol at 40 μg/g. A dose dependent reduction in growth rate occurred by 14 days of treatment with cortisol, whereas hepatosomatic index was not affected. We will report igfbp transcript levels in liver, skeletal muscle and gill with an aim to resolve how activities within the Igfbp network are modulated by cortisol in juvenile Atlantic salmon. Support or Funding Information Supported by Start‐Up funds to J.P.B. |
format |
Article in Journal/Newspaper |
author |
Springer‐Miller, Ryan Chenoweth, Damaris Paskavitz, Amanda Regish, Amy McCormick, Stephen Breves, Jason |
spellingShingle |
Springer‐Miller, Ryan Chenoweth, Damaris Paskavitz, Amanda Regish, Amy McCormick, Stephen Breves, Jason Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr |
author_facet |
Springer‐Miller, Ryan Chenoweth, Damaris Paskavitz, Amanda Regish, Amy McCormick, Stephen Breves, Jason |
author_sort |
Springer‐Miller, Ryan |
title |
Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr |
title_short |
Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr |
title_full |
Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr |
title_fullStr |
Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr |
title_full_unstemmed |
Effect of Cortisol on Growth and Gene Expression of insulin‐like growth‐factor binding proteins (igfbps) in Atlantic Salmon Parr |
title_sort |
effect of cortisol on growth and gene expression of insulin‐like growth‐factor binding proteins (igfbps) in atlantic salmon parr |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1096/fasebj.31.1_supplement.719.14 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
The FASEB Journal volume 31, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.31.1_supplement.719.14 |
container_title |
The FASEB Journal |
container_volume |
31 |
container_issue |
S1 |
_version_ |
1800748001381056512 |