Glucocorticoid Receptor‐mediated Lipolysis Increases following Chronic Adrenocorticotropin Infusion in Northern Elephant Seals Pups through its Imperative Interaction with Heat Shock 90 Chaperone Protein

• Published in: The FASEB Journal
• Main Authors: Juarez, Pablo, Lee, Debby, Crocker, Daniel, Vasquez‐Medina, Jose Pablo, Ortiz, Rudy
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2016
• Subjects: Nes; Nes’; Elephant Seal; Elephant Seals
• Online Access: http://dx.doi.org/10.1096/fasebj.30.1_supplement.979.3

Northern elephant seal (NES) pups experience a prolonged 2–3 month fasting period and rely primarily on the oxidation of fatty acids to meet its energetic needs. Heat shock 90 chaperone protein (HSP90) is a fundamental part of the glucocorticoid‐cortisol (GR) complex, inducing an up regulation in GR...