Formate: A New Frontier in Fetal One‐Carbon Metabolism

• Published in: The FASEB Journal
• Main Authors: MacMillan, Luke, Harnett, Brian J, Quilty, Rebecca, Tingley, Garrett, Brosnan, Margaret E., Brosnan, John T.
• Other Authors: Research and Development Corporation of Newfoundland and Labrador, Canadian Institutes of Health Research
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2016
• Subjects: Newfoundland; Washburn
• Online Access: http://dx.doi.org/10.1096/fasebj.30.1_supplement.1171.3

For years the significance of formate in one‐carbon metabolism has been underappreciated. It is known that formate can be produced by the mitochondria and incorporated into the cytosolic tetrahydrofolate pool where its carbon is used for three canonical processes i) purine synthesis ii) thymidylate...