Alaskan Botanicals Influence Neuronal Aging
Aging is a risk factor for many life‐threatening disorders, including neurodegenerative diseases. Many genetic mutations and environmental factors that increase lifespan may also postpone these age‐related diseases. The overall goal of this project is to examine the effect of Alaskan botanicals on t...
Published in: | The FASEB Journal |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2015
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1096/fasebj.29.1_supplement.657.3 |
id |
crwiley:10.1096/fasebj.29.1_supplement.657.3 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1096/fasebj.29.1_supplement.657.3 2024-06-02T08:02:21+00:00 Alaskan Botanicals Influence Neuronal Aging Scerbak, Courtney Vayndorf, Elena McGill, Colin Taylor, Barbara 2015 http://dx.doi.org/10.1096/fasebj.29.1_supplement.657.3 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 29, issue S1 ISSN 0892-6638 1530-6860 journal-article 2015 crwiley https://doi.org/10.1096/fasebj.29.1_supplement.657.3 2024-05-03T11:53:27Z Aging is a risk factor for many life‐threatening disorders, including neurodegenerative diseases. Many genetic mutations and environmental factors that increase lifespan may also postpone these age‐related diseases. The overall goal of this project is to examine the effect of Alaskan botanicals on the aging nervous system, using the nematode model system, Caenorhabditis elegans . We tested the impact of crude extracts from three edible, medicinally beneficial Interior Alaskan botanicals ( Vaccinium uliginosum [bog blueberry], Empetrum nigrum [crowberry], Vaccinium vitis‐idaea [lowbush cranberry], Inonotus obliquus [chaga]) on whole animal lifespan and markers of neuronal aging. Specifically, we evaluated age‐ and botanical‐related changes in neuronal morphology and function of mechanosensory and GABAergic motor neurons using fluorescently labeled C. elegans strains. We find that these botanicals are able to extend wildtype C. elegans lifespan by up to 35%. Preliminary results suggest that mechanosensory neuronal morphology and function are also affected, but not GABA‐ergic neurons. We explored the mechanism of action of these botanicals through determining the extracts' phenolic, flavonoid, and anthocyanin composition and in vivo DAF‐16, SKN‐1, and HSF‐1 transcription factor activation following treatments. Through this botanical screen, we will scientifically validate and underscore the value of ecological resources endemic to the Arctic, elucidate the mechanism of changing neuronal morphology and functionality with age, and, perhaps, establish precedent for novel therapies for neurodegenerative diseases. Article in Journal/Newspaper Arctic Crowberry Empetrum nigrum Wiley Online Library Arctic The FASEB Journal 29 S1 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Aging is a risk factor for many life‐threatening disorders, including neurodegenerative diseases. Many genetic mutations and environmental factors that increase lifespan may also postpone these age‐related diseases. The overall goal of this project is to examine the effect of Alaskan botanicals on the aging nervous system, using the nematode model system, Caenorhabditis elegans . We tested the impact of crude extracts from three edible, medicinally beneficial Interior Alaskan botanicals ( Vaccinium uliginosum [bog blueberry], Empetrum nigrum [crowberry], Vaccinium vitis‐idaea [lowbush cranberry], Inonotus obliquus [chaga]) on whole animal lifespan and markers of neuronal aging. Specifically, we evaluated age‐ and botanical‐related changes in neuronal morphology and function of mechanosensory and GABAergic motor neurons using fluorescently labeled C. elegans strains. We find that these botanicals are able to extend wildtype C. elegans lifespan by up to 35%. Preliminary results suggest that mechanosensory neuronal morphology and function are also affected, but not GABA‐ergic neurons. We explored the mechanism of action of these botanicals through determining the extracts' phenolic, flavonoid, and anthocyanin composition and in vivo DAF‐16, SKN‐1, and HSF‐1 transcription factor activation following treatments. Through this botanical screen, we will scientifically validate and underscore the value of ecological resources endemic to the Arctic, elucidate the mechanism of changing neuronal morphology and functionality with age, and, perhaps, establish precedent for novel therapies for neurodegenerative diseases. |
format |
Article in Journal/Newspaper |
author |
Scerbak, Courtney Vayndorf, Elena McGill, Colin Taylor, Barbara |
spellingShingle |
Scerbak, Courtney Vayndorf, Elena McGill, Colin Taylor, Barbara Alaskan Botanicals Influence Neuronal Aging |
author_facet |
Scerbak, Courtney Vayndorf, Elena McGill, Colin Taylor, Barbara |
author_sort |
Scerbak, Courtney |
title |
Alaskan Botanicals Influence Neuronal Aging |
title_short |
Alaskan Botanicals Influence Neuronal Aging |
title_full |
Alaskan Botanicals Influence Neuronal Aging |
title_fullStr |
Alaskan Botanicals Influence Neuronal Aging |
title_full_unstemmed |
Alaskan Botanicals Influence Neuronal Aging |
title_sort |
alaskan botanicals influence neuronal aging |
publisher |
Wiley |
publishDate |
2015 |
url |
http://dx.doi.org/10.1096/fasebj.29.1_supplement.657.3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Crowberry Empetrum nigrum |
genre_facet |
Arctic Crowberry Empetrum nigrum |
op_source |
The FASEB Journal volume 29, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.29.1_supplement.657.3 |
container_title |
The FASEB Journal |
container_volume |
29 |
container_issue |
S1 |
_version_ |
1800746860467453952 |