Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7)
The recent rise in obesity is tightly associated with an increase in diseases such as type 2 diabetes, cardiovascular disease and hepatic steatosis. Ramalin, isolated from the Antarctic lichen Ramalin terebrata , has been known to have various biological activities including anti‐inflammatory activi...
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Online Access: | http://dx.doi.org/10.1096/fasebj.28.1_supplement.824.7 |
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crwiley:10.1096/fasebj.28.1_supplement.824.7 2024-06-02T07:56:16+00:00 Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) Park, Bongkyun Lee, Chunggi Jang, Yeonjeong Pyo, Suhkneung 2014 http://dx.doi.org/10.1096/fasebj.28.1_supplement.824.7 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 28, issue S1 ISSN 0892-6638 1530-6860 journal-article 2014 crwiley https://doi.org/10.1096/fasebj.28.1_supplement.824.7 2024-05-03T11:40:12Z The recent rise in obesity is tightly associated with an increase in diseases such as type 2 diabetes, cardiovascular disease and hepatic steatosis. Ramalin, isolated from the Antarctic lichen Ramalin terebrata , has been known to have various biological activities including anti‐inflammatory activity. However, other biological activities of ramalin remain unknown. We examined the anti‐obesity effect of ramalin in five week‐old mice that were fed either a control high‐fat diet (HFD), or HFD with oral administration 50 mg/kg or 100 mg/kg of ramalin for 8 weeks. Mice fed with ramalin showed 25% reduced body weight gain and ramalin treatment significantly inhibited epididymal fat‐pad weights compared with mice fed with HFD. Ramalin also reduced the levels of glucose, hepatic triglyceride, serum total, high‐density lipoprotein (HDL) and Low‐density lipoprotein (LDL) cholesterol. ELISA assay revealed that ramalin remarkably inhibited HFD‐induced leptin cytokine level. Furthermore, Real time PCR assay showed that HFD‐induced adipose tissue genes, known as adipogenesis markers, were significantly suppressed by ramalin. Overall, these results suggest that ramalin might be a plausible candidate to control obesity and obesity‐related disorders. Article in Journal/Newspaper Antarc* Antarctic Wiley Online Library Antarctic The Antarctic The FASEB Journal 28 S1 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
The recent rise in obesity is tightly associated with an increase in diseases such as type 2 diabetes, cardiovascular disease and hepatic steatosis. Ramalin, isolated from the Antarctic lichen Ramalin terebrata , has been known to have various biological activities including anti‐inflammatory activity. However, other biological activities of ramalin remain unknown. We examined the anti‐obesity effect of ramalin in five week‐old mice that were fed either a control high‐fat diet (HFD), or HFD with oral administration 50 mg/kg or 100 mg/kg of ramalin for 8 weeks. Mice fed with ramalin showed 25% reduced body weight gain and ramalin treatment significantly inhibited epididymal fat‐pad weights compared with mice fed with HFD. Ramalin also reduced the levels of glucose, hepatic triglyceride, serum total, high‐density lipoprotein (HDL) and Low‐density lipoprotein (LDL) cholesterol. ELISA assay revealed that ramalin remarkably inhibited HFD‐induced leptin cytokine level. Furthermore, Real time PCR assay showed that HFD‐induced adipose tissue genes, known as adipogenesis markers, were significantly suppressed by ramalin. Overall, these results suggest that ramalin might be a plausible candidate to control obesity and obesity‐related disorders. |
format |
Article in Journal/Newspaper |
author |
Park, Bongkyun Lee, Chunggi Jang, Yeonjeong Pyo, Suhkneung |
spellingShingle |
Park, Bongkyun Lee, Chunggi Jang, Yeonjeong Pyo, Suhkneung Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
author_facet |
Park, Bongkyun Lee, Chunggi Jang, Yeonjeong Pyo, Suhkneung |
author_sort |
Park, Bongkyun |
title |
Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
title_short |
Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
title_full |
Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
title_fullStr |
Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
title_full_unstemmed |
Anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
title_sort |
anti‐obese effect of ramalin in high‐fat diet‐induced obese mice (824.7) |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1096/fasebj.28.1_supplement.824.7 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
The FASEB Journal volume 28, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.28.1_supplement.824.7 |
container_title |
The FASEB Journal |
container_volume |
28 |
container_issue |
S1 |
_version_ |
1800754653207461888 |