Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup
Northern elephant seal pups fast for 2–3 months post‐weaning during which they show various symptoms associated with insulin resistance (e.g. reduced glucose clearance and insulin signaling, and increased plasma lipids). However, because fasting pups also show decreased plasma insulin, it remains un...
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Online Access: | http://dx.doi.org/10.1096/fasebj.27.1_supplement.714.21 |
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crwiley:10.1096/fasebj.27.1_supplement.714.21 2024-06-02T08:05:59+00:00 Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup Viscarra, Jose A Crocker, Daniel E Ortiz, Rudy M 2013 http://dx.doi.org/10.1096/fasebj.27.1_supplement.714.21 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 27, issue S1 ISSN 0892-6638 1530-6860 journal-article 2013 crwiley https://doi.org/10.1096/fasebj.27.1_supplement.714.21 2024-05-03T11:08:49Z Northern elephant seal pups fast for 2–3 months post‐weaning during which they show various symptoms associated with insulin resistance (e.g. reduced glucose clearance and insulin signaling, and increased plasma lipids). However, because fasting pups also show decreased plasma insulin, it remains unclear whether or not decreased insulin action is a result of decreased insulin sensitivity. To address the hypothesis that fasting induces insulin resistance in elephant seal pups, early (n=5) and late (n=5) fasted seals were infused with a mass specific dose of insulin (0.065 U/kg). Glucose clearance was similar in both periods (1.08 mg/dL/min vs. 1.05 mg/dL/min), however insulin‐signaling activity was 15% lower in late fasted seals. Plasma lipids were decreased to a greater degree in the early fasted seals than in late fasted seals. Glucose clearance of fasting pups is 70% slower than seen in insulin sensitive mammals. Additionally, reduced insulin signaling activity paired with reduced inhibition of lipolysis in late fasted seals demonstrates that insulin sensitivity declines further with fasting. These results definitively show that fasting elephant seal pups are insulin resistant. Furthermore, because fasting, insulin resistant pups are able to maintain control of their metabolism, these results strengthen the idea that insulin resistance is an adaptation to prolonged fasting. Article in Journal/Newspaper Elephant Seal Wiley Online Library The FASEB Journal 27 S1 |
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Wiley Online Library |
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English |
description |
Northern elephant seal pups fast for 2–3 months post‐weaning during which they show various symptoms associated with insulin resistance (e.g. reduced glucose clearance and insulin signaling, and increased plasma lipids). However, because fasting pups also show decreased plasma insulin, it remains unclear whether or not decreased insulin action is a result of decreased insulin sensitivity. To address the hypothesis that fasting induces insulin resistance in elephant seal pups, early (n=5) and late (n=5) fasted seals were infused with a mass specific dose of insulin (0.065 U/kg). Glucose clearance was similar in both periods (1.08 mg/dL/min vs. 1.05 mg/dL/min), however insulin‐signaling activity was 15% lower in late fasted seals. Plasma lipids were decreased to a greater degree in the early fasted seals than in late fasted seals. Glucose clearance of fasting pups is 70% slower than seen in insulin sensitive mammals. Additionally, reduced insulin signaling activity paired with reduced inhibition of lipolysis in late fasted seals demonstrates that insulin sensitivity declines further with fasting. These results definitively show that fasting elephant seal pups are insulin resistant. Furthermore, because fasting, insulin resistant pups are able to maintain control of their metabolism, these results strengthen the idea that insulin resistance is an adaptation to prolonged fasting. |
format |
Article in Journal/Newspaper |
author |
Viscarra, Jose A Crocker, Daniel E Ortiz, Rudy M |
spellingShingle |
Viscarra, Jose A Crocker, Daniel E Ortiz, Rudy M Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup |
author_facet |
Viscarra, Jose A Crocker, Daniel E Ortiz, Rudy M |
author_sort |
Viscarra, Jose A |
title |
Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup |
title_short |
Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup |
title_full |
Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup |
title_fullStr |
Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup |
title_full_unstemmed |
Prolonged Fasting Induces Insulin Resistance in the Northern Elephant Seal Pup |
title_sort |
prolonged fasting induces insulin resistance in the northern elephant seal pup |
publisher |
Wiley |
publishDate |
2013 |
url |
http://dx.doi.org/10.1096/fasebj.27.1_supplement.714.21 |
genre |
Elephant Seal |
genre_facet |
Elephant Seal |
op_source |
The FASEB Journal volume 27, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.27.1_supplement.714.21 |
container_title |
The FASEB Journal |
container_volume |
27 |
container_issue |
S1 |
_version_ |
1800750868322058240 |